Detailed information for compound 1258620

Basic information

Technical information
  • TDR Targets ID: 1258620
  • Name: (5E)-5-(1-ethoxyethylidene)-2-sulfanylidene-1 ,3-thiazolidin-4-one
  • MW: 203.282 | Formula: C7H9NO2S2
  • H donors: 1 H acceptors: 1 LogP: 1.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C/1\SC(=S)NC1=O)/OCC
  • InChi: 1S/C7H9NO2S2/c1-3-10-4(2)5-6(9)8-7(11)12-5/h3H2,1-2H3,(H,8,9,11)/b5-4+
  • InChiKey: MOWRYXSVQDYHLJ-SNAWJCMRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-5-(1-ethoxyethylidene)-2-thioxo-thiazolidin-4-one
  • (5E)-5-(1-ethoxyethylidene)-2-thioxo-4-thiazolidinone
  • 5-(1-ethoxyethylidene)-2-thioxo-1,3-thiazolan-4-one
  • IDI1_016193
  • SMR000459844
  • HcNDPLxPBDBDfUV|jZiZjAEP
  • MLS000861060
  • RB 00180
  • SR-01000644892-1
  • ZINC01041679

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0272 0.015
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0025 0.0028
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0111 0.3463 0.6653
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.00000000019122 0.00000000055215
Echinococcus granulosus protein C ets 2 0.0013 0.0025 0.0073
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.2648 0.2977
Schistosoma mansoni hypothetical protein 0.0013 0.0025 0.0028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.1045 0.0933
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0354 0.0398
Toxoplasma gondii exonuclease III APE 0.002 0.0272 0.0786
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0025 0.0073
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0025 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0028
Toxoplasma gondii hypothetical protein 0.0048 0.1261 0.364
Loa Loa (eye worm) RecQ helicase 0.0029 0.0597 0.0671
Brugia malayi transcription factor E74 isoform 0.0013 0.0025 0.0028
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0354 0.1022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0272 1
Brugia malayi Ets-domain containing protein 0.0013 0.0025 0.0028
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0354 0.1022
Toxoplasma gondii leucyl aminopeptidase LAP 0.0111 0.3463 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.1045 0.0933
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0354 0.0398
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0025 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 1 1
Schistosoma mansoni elf1 0.0013 0.0025 0.0028
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0272 0.0306
Schistosoma mansoni ets 0.0013 0.0025 0.0028
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0025 0.0073
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0597 0.0671
Schistosoma mansoni gabp alpha 0.0087 0.2648 0.2977
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0025 0.0073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0272 0.0306
Schistosoma mansoni ap endonuclease 0.002 0.0272 0.0306
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0272 0.015
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0597 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.026 0.075
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.4512 0.4443
Brugia malayi Fli-1 protein 0.0265 0.8895 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0597 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1366 0.1258
Echinococcus multilocularis ets variant gene 4 0.0013 0.0025 0.0073
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0025 0.0073
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0025 0.0073
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0354 0.0398
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0025 0.0073
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0025 0.0028
Mycobacterium ulcerans hypothetical protein 0.0156 0.5069 1
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.2648 0.7647
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0354 0.0398
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0272 0.3137
Plasmodium falciparum M17 leucyl aminopeptidase 0.0111 0.3463 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0272 0.0786
Echinococcus granulosus leucine aminopeptidase protein 0.0111 0.3463 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0111 0.3463 0.3381
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.1045 0.0933
Loa Loa (eye worm) fli-1 protein 0.0265 0.8895 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.2203 0.2477
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.4512 0.4443
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0597 0.1725
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0025 0.0073
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0025 0.0073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0474 0.1368
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.2648 0.7647
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0354 0.0233
Brugia malayi cytosol aminopeptidase 0.0022 0.0354 0.0398
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0272 0.3137
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0272 0.0786
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0111 0.3463 0.5
Mycobacterium ulcerans leucyl aminopeptidase 0.0111 0.3463 0.6653
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0111 0.3463 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0272 0.0013
Echinococcus granulosus bloom syndrome protein 0.0029 0.0597 0.1725
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0025 0.0028
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0354 0.0398
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0354 0.0398
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0272 0.0786
Loa Loa (eye worm) hypothetical protein 0.0146 0.47 0.5284
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.1045 0.0933
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0025 0.0073
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0272 1
Schistosoma mansoni ets-related 0.0013 0.0025 0.0028
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Schistosoma mansoni hypothetical protein 0.0013 0.0025 0.0028
Chlamydia trachomatis cytosol aminopeptidase 0.0111 0.3463 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.5069 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0272 0.015
Brugia malayi Ets-domain containing protein 0.0087 0.2648 0.2977
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.4512 0.4443
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0111 0.3463 0.3381
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0111 0.3463 0.3381
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0354 0.1022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0272 0.015
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0025 0.0028
Schistosoma mansoni ets-related 0.0265 0.8895 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0354 0.0398
Schistosoma mansoni ap endonuclease 0.002 0.0272 0.0306
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0354 0.1022
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0354 0.1022
Echinococcus multilocularis leucine aminopeptidase protein 0.0111 0.3463 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 1 1
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0354 0.1022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0028
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0111 0.3463 0.3381
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0025 0.0073
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0383 0.0431
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0354 0.0233
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0025 0.0028
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0025 0.0028
Echinococcus multilocularis protein C ets 2 0.0013 0.0025 0.0073
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0272 0.5
Brugia malayi Ets-domain containing protein 0.0087 0.2648 0.2977
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0111 0.3463 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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