Detailed information for compound 1258735

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.658 | Formula: C28H22KN3S
  • H donors: 0 H acceptors: 2 LogP: 6.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [S-]c1nnc(n1Cc1ccccc1c1ccccc1)Cc1ccc(cc1)c1ccccc1.[K+]
  • InChi: 1S/C28H23N3S.K/c32-28-30-29-27(19-21-15-17-23(18-16-21)22-9-3-1-4-10-22)31(28)20-25-13-7-8-14-26(25)24-11-5-2-6-12-24;/h1-18H,19-20H2,(H,30,32);/q;+1/p-1
  • InChiKey: XBECYABGQAQANF-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0014 0.0195 0.0337
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.041
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1853 0.2863
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.019 0.3716
Loa Loa (eye worm) hypothetical protein 0.002 0.0392 0.0606
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0978 0.1512
Treponema pallidum fructose-bisphosphate aldolase 0.0313 1 1
Schistosoma mansoni hypothetical protein 0.001 0.0074 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.58 0.8963
Echinococcus granulosus jumonji domain containing protein 0.0043 0.1164 0.1799
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0763 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.58 0.9099
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0108
Toxoplasma gondii exonuclease III APE 0.0019 0.0355 0.4118
Brugia malayi hypothetical protein 0.0014 0.0195 0.0337
Schistosoma mansoni tyrosine kinase 0.0202 0.6375 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0392 1
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0355 0.0549
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0261 0.0404
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0763 0.1179
Schistosoma mansoni jumonji domain containing protein 0.0081 0.2403 0.3769
Brugia malayi Trypsin family protein 0.0014 0.0195 0.0337
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0392 0.0084
Echinococcus multilocularis tyrosine protein kinase Abl 0.0084 0.2484 0.3838
Brugia malayi Trypsin family protein 0.0014 0.0195 0.0337
Plasmodium vivax hypothetical protein, conserved 0.001 0.0074 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1388 0.2145
Echinococcus multilocularis phd:f box containing protein 0.001 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.58 0.9099
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0074 0.0128
Schistosoma mansoni hypothetical protein 0.0175 0.5471 0.8582
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.019 0.3716
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Echinococcus granulosus peregrin 0.0031 0.0763 0.1179
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0195 0.0337
Schistosoma mansoni hypothetical protein 0.0031 0.0763 0.1197
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0978 0.1535
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.3317 0.5204
Echinococcus multilocularis GPCR, family 2 0.0016 0.0261 0.0404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0355 0.8854
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Echinococcus granulosus tyrosine protein kinase ABL1 0.0205 0.6471 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0392 0.0606
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.007 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0392 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.58 0.9099
Echinococcus granulosus dna polymerase eta 0.002 0.0392 0.0606
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.007 0.0108
Brugia malayi Tyrosine-protein kinase abl-1 0.0084 0.2484 0.4282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0313 1 1
Brugia malayi Trypsin family protein 0.0014 0.0195 0.0337
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0866 0.1494
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.3092 0.4778
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.007 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0074 0.006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0392 0.0606
Echinococcus multilocularis peregrin 0.0031 0.0763 0.1179
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.3092 0.4778
Schistosoma mansoni phosphatidylserine receptor 0.001 0.007 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0763 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0392 0.0606
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0195 0.0302
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0355 0.8854
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Loa Loa (eye worm) hypothetical protein 0.0054 0.1494 0.2309
Trypanosoma brucei unspecified product 0.0014 0.019 0.3716
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.4752 1
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.041
Echinococcus multilocularis dna polymerase eta 0.002 0.0392 0.0606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0261 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0392 0.0433
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0195 0.0302
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0392 0.0676
Loa Loa (eye worm) hypothetical protein 0.0034 0.0866 0.1339
Brugia malayi jmjC domain containing protein 0.001 0.007 0.0121
Onchocerca volvulus 0.0014 0.0195 0.2558
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0392 0.0676
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0074 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0392 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0763 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0355 0.0352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0261 0.0404
Leishmania major DNA polymerase kappa, putative 0.002 0.0392 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0392 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Echinococcus multilocularis enteropeptidase 0.0014 0.0195 0.0302
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0978 0.1512
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.007 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1388 0.2393
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0261 0.0404
Schistosoma mansoni protein phosphatase 2C 0.001 0.007 0.011
Entamoeba histolytica hypothetical protein 0.0109 0.3317 0.3317
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0392 0.0433
Brugia malayi Bromodomain containing protein 0.0031 0.0763 0.1316
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0355 0.4118
Brugia malayi hypothetical protein 0.0109 0.3317 0.5719
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0355 0.5
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0074 0.006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1388 0.2393
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Loa Loa (eye worm) hypothetical protein 0.005 0.1388 0.2145
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0355 0.0613
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0074 0.0116
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0763 0.1179
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0392 1
Brugia malayi jmjC domain containing protein 0.001 0.007 0.0121
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0195 0.0302
Echinococcus granulosus GPCR family 2 0.0016 0.0261 0.0404
Loa Loa (eye worm) TK/ABL protein kinase 0.0205 0.6471 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Echinococcus granulosus geminin 0.0175 0.5471 0.8454
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0763 0.1197
Giardia lamblia DINP protein human, muc B family 0.002 0.0392 0.0038
Onchocerca volvulus 0.0014 0.0195 0.2558
Brugia malayi jmjC domain containing protein 0.001 0.007 0.0121
Schistosoma mansoni hypothetical protein 0.0175 0.5471 0.8582
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0195 0.0302
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.58 0.8963
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.007 0.0108
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.3821 0.6588
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Schistosoma mansoni hypothetical protein 0.0014 0.0195 0.0306
Onchocerca volvulus 0.0014 0.0195 0.2558
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0261 0.0404
Onchocerca volvulus 0.0014 0.0195 0.2558
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0355 0.8854
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0261 0.045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0355 0.0549
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.4752 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0392 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0763 1
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0978 0.1512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0355 0.8854
Brugia malayi jmjC domain containing protein 0.0038 0.0978 0.1687
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0195 0.0302
Brugia malayi PHD-finger family protein 0.0031 0.0763 0.1316
Brugia malayi AF-10 protein 0.001 0.0074 0.0128
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0392 0.0392
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.007 0.011
Brugia malayi jmjC domain containing protein 0.0102 0.3092 0.533
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0205 0.6471 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0392 0.0606
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.3317 0.5126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.58 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Entamoeba histolytica hypothetical protein 0.0109 0.3317 0.3317
Loa Loa (eye worm) trypsin family protein 0.0014 0.0195 0.0302
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0355 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0763 0.1179
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0195 0.0302
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0074 0.006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0261 0.045
Echinococcus multilocularis Mastin 0.0014 0.0195 0.0302
Onchocerca volvulus Alhambra homolog 0.0031 0.0763 1
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.1164 0.1799
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0392 1
Onchocerca volvulus 0.0014 0.0195 0.2558
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.58 0.8963
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Onchocerca volvulus 0.0014 0.0195 0.2558
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.3317 0.5126
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0195 0.0337
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Schistosoma mansoni hypothetical protein 0.0109 0.3317 0.5204
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0195 0.0302
Echinococcus multilocularis geminin 0.0175 0.5471 0.8454
Brugia malayi jmjC domain containing protein 0.001 0.007 0.0121
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0195 0.0306
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0392 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.007 0.0108
Giardia lamblia PHD finger protein 15 0.0031 0.0763 0.0423
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0763 0.1179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0978 0.1535
Schistosoma mansoni hypothetical protein 0.0034 0.0866 0.1359
Schistosoma mansoni hypothetical protein 0.0014 0.0195 0.0306
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0355 0.0355
Schistosoma mansoni ap endonuclease 0.0019 0.0355 0.0558
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.041
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0302
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0392 0.0084
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0195 0.0306
Brugia malayi PHD-finger family protein 0.001 0.0074 0.0128
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0074 0.0129
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0392 1
Trypanosoma brucei unspecified product 0.0014 0.019 0.3716
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.58 0.8963
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0195 0.0306
Echinococcus granulosus Mastin 0.0014 0.0195 0.0302
Entamoeba histolytica hypothetical protein 0.0109 0.3317 0.3317
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.4752 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0355 0.0549
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0392 0.0606
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.007 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0392 1
Schistosoma mansoni phd/f-box containing protein 0.001 0.007 0.011
Entamoeba histolytica hypothetical protein 0.0109 0.3317 0.3317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.58 0.8963
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.007 0.0108
Giardia lamblia Fructose-bisphosphate aldolase 0.0313 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0392 0.0616
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.007 0.0108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0392 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.019 0.3716
Echinococcus granulosus jumonji domain containing 1A 0.001 0.007 0.0108
Schistosoma mansoni jumonji domain containing protein 0.001 0.007 0.011
Trypanosoma brucei unspecified product 0.002 0.0392 1
Schistosoma mansoni ap endonuclease 0.0019 0.0355 0.0558
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0355 0.4118
Schistosoma mansoni DNA polymerase eta 0.002 0.0392 0.0616
Echinococcus granulosus enteropeptidase 0.0014 0.0195 0.0302
Echinococcus granulosus phd:f box containing protein 0.001 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0078 0.2293 0.3544
Leishmania major DNA polymerase eta, putative 0.002 0.0392 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of ADAMTS-5 by spectrophotometry ChEMBL. 20846863

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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