Detailed information for compound 1258848

Basic information

Technical information
  • TDR Targets ID: 1258848
  • Name: 1-methyl-4-[3-[(4-methyl-1,2,4-triazol-3-yl)s ulfanyl]-4-nitrophenyl]piperazine
  • MW: 334.397 | Formula: C14H18N6O2S
  • H donors: 0 H acceptors: 4 LogP: 1.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ccc(c(c1)Sc1nncn1C)[N+](=O)[O-]
  • InChi: 1S/C14H18N6O2S/c1-17-5-7-19(8-6-17)11-3-4-12(20(21)22)13(9-11)23-14-16-15-10-18(14)2/h3-4,9-10H,5-8H2,1-2H3
  • InChiKey: GBRUTJVWVZGMMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-methyl-4-[3-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-4-nitro-phenyl]piperazine
  • 1-methyl-4-[3-[(4-methyl-1,2,4-triazol-3-yl)thio]-4-nitrophenyl]piperazine
  • 1-methyl-4-[3-[(4-methyl-1,2,4-triazol-3-yl)thio]-4-nitro-phenyl]piperazine
  • 1-methyl-4-{3-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]-4-nitrophenyl}piperazine
  • MLS000662063
  • SMR000292708
  • STK107787

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0144 0.2725 0.2725
Trypanosoma cruzi adenosine kinase, putative 0.004 0.0514 0.0725
Entamoeba histolytica hypothetical protein 0.0119 0.2205 0.2094
Echinococcus granulosus muscleblind protein 0.018 0.3509 0.3509
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0189 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1083 0.1083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1083 0.1083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1083 0.1083
Mycobacterium tuberculosis Adenosine kinase 0.004 0.0514 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0064 0.1022 0.0894
Echinococcus granulosus nibrin 0.0064 0.1022 0.1022
Trypanosoma brucei purine nucleoside transporter 0.0084 0.1462 0.2063
Trypanosoma cruzi nucleobase transporter, putative 0.0084 0.1462 0.2063
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0311 0.0439
Schistosoma mansoni ran 0.0022 0.0141 0.0198
Echinococcus granulosus replication factor c subunit 1 0.0064 0.1022 0.1022
Schistosoma mansoni hypothetical protein 0.0322 0.6528 0.9149
Trypanosoma brucei adenosine transporter 2 0.0084 0.1462 0.2063
Brugia malayi Importin beta-1 subunit 0.003 0.0311 0.0311
Plasmodium vivax replication factor C subunit 1, putative 0.0064 0.1022 1
Trypanosoma brucei adenosine transporter 2, putative 0.0084 0.1462 0.2063
Echinococcus multilocularis adenosine kinase 0.0349 0.709 0.709
Giardia lamblia Replication factor C, subunit 1 0.0064 0.1022 0.0894
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0084 0.1462 0.134
Entamoeba histolytica hypothetical protein 0.0119 0.2205 0.2094
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.004 0.0514 0.0378
Schistosoma mansoni hypothetical protein 0.0351 0.7135 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0311 0.0311
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0141 0.1382
Echinococcus multilocularis snurportin 1 0.0322 0.6528 0.6528
Loa Loa (eye worm) hypothetical protein 0.0485 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0141 0.0141
Toxoplasma gondii nucleoside transporter protein 0.0084 0.1462 0.2063
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0084 0.1462 0.2063
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.004 0.0514 0.0514
Leishmania major importin beta-1 subunit, putative 0.0024 0.0189 0.0267
Schistosoma mansoni hypothetical protein 0.0066 0.1083 0.1518
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0141 0.0141
Trypanosoma cruzi nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Toxoplasma gondii ATPase, AAA family protein 0.0064 0.1022 0.1442
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0311 0.0439
Brugia malayi RNA binding protein 0.0197 0.3872 0.3872
Trypanosoma cruzi nucleoside transporter-like, putative 0.0084 0.1462 0.2063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1083 0.1083
Toxoplasma gondii nucleoside transporter protein 0.0084 0.1462 0.2063
Trichomonas vaginalis ribokinase, putative 0.004 0.0514 0.0378
Entamoeba histolytica hypothetical protein 0.0024 0.0189 0.0049
Brugia malayi Ribokinase 0.004 0.0514 0.0514
Schistosoma mansoni hypothetical protein 0.0351 0.7135 1
Trypanosoma cruzi nucleobase transporter, putative 0.0084 0.1462 0.2063
Trichomonas vaginalis ribokinase, putative 0.004 0.0514 0.0378
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0084 0.1462 0.2063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.4677 0.4677
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1022 0.1442
Schistosoma mansoni hypothetical protein 0.0066 0.1083 0.1518
Leishmania major adenosine kinase, putative 0.0349 0.709 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Echinococcus granulosus adenosine kinase 0.0349 0.709 0.709
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1022 0.0894
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Brugia malayi Pax transcription activation domain interacting protein 0.0064 0.1022 0.1022
Brugia malayi topoisomerase 0.0064 0.1022 0.1022
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0084 0.1462 0.2063
Leishmania major GTP-binding protein, putative 0.0022 0.0141 0.0199
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0084 0.1462 0.134
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0084 0.1462 0.2063
Schistosoma mansoni hypothetical protein 0.0066 0.1083 0.1518
Plasmodium falciparum replication factor C subunit 1, putative 0.0064 0.1022 1
Toxoplasma gondii kinase, pfkB family protein 0.004 0.0514 0.0725
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0141 0.0199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.2205 0.2205
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0084 0.1462 0.134
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0485 1 1
Loa Loa (eye worm) RNA binding protein 0.0197 0.3872 0.3872
Leishmania major adenosine kinase-like protein 0.004 0.0514 0.0725
Echinococcus multilocularis tar DNA binding protein 0.0197 0.3872 0.3872
Schistosoma mansoni ribokinase 0.004 0.0514 0.072
Trichomonas vaginalis replication factor C large subunit, putative 0.0064 0.1022 0.0894
Giardia lamblia Hypothetical protein 0.0485 1 1
Brugia malayi DKFZp564C0469 protein 0.0064 0.1022 0.1022
Brugia malayi hypothetical protein 0.004 0.0514 0.0514
Entamoeba histolytica hypothetical protein 0.0119 0.2205 0.2094
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Leishmania major nucleobase transporter 0.0084 0.1462 0.2063
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0485 1 1
Toxoplasma gondii kinase, pfkB family protein 0.0349 0.709 1
Echinococcus multilocularis replication factor c subunit 1 0.0064 0.1022 0.1022
Schistosoma mansoni adenosine kinase 0.0349 0.709 0.9936
Loa Loa (eye worm) hypothetical protein 0.004 0.0514 0.0514
Trypanosoma cruzi adenosine kinase, putative 0.004 0.0514 0.0725
Brugia malayi Adenosine kinase-like 0.0349 0.709 0.709
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0189 0.0267
Brugia malayi hypothetical protein 0.0064 0.1022 0.1022
Brugia malayi STAT protein, DNA binding domain containing protein 0.013 0.243 0.243
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1022 0.0894
Schistosoma mansoni chromosome transmission fidelity factor 0.0064 0.1022 0.1433
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0485 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1022 0.1442
Brugia malayi hypothetical protein 0.0084 0.1462 0.1462
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.2205 0.2205
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.3872 0.3872
Leishmania major nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Schistosoma mansoni protein kinase 0.0084 0.1462 0.205
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Treponema pallidum DNA ligase (lig) 0.0064 0.1022 0.5
Schistosoma mansoni topbp1 0.0064 0.1022 0.1433
Schistosoma mansoni DNA ligase IV 0.0064 0.1022 0.1433
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0485 1 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0064 0.1022 0.1442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.414 0.414
Trypanosoma cruzi adenosine kinase, putative 0.0349 0.709 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1462 0.1462
Trypanosoma cruzi nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1022 0.0894
Trypanosoma brucei nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Echinococcus multilocularis muscleblind protein 0.018 0.3509 0.3509
Trypanosoma cruzi nucleobase transporter, putative 0.0084 0.1462 0.2063
Entamoeba histolytica nucleoside transporter, putative 0.0084 0.1462 0.134
Loa Loa (eye worm) hypothetical protein 0.018 0.3509 0.3509
Brugia malayi RNA, U transporter 1 0.0086 0.1496 0.1496
Brugia malayi MH2 domain containing protein 0.0118 0.2175 0.2175
Entamoeba histolytica kinase, PfkB family 0.004 0.0514 0.0378
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0064 0.1022 1
Trypanosoma brucei adenosine kinase, putative 0.0349 0.709 1
Entamoeba histolytica nucleoside transporter, putative 0.0485 1 1
Loa Loa (eye worm) hypothetical protein 0.021 0.414 0.414
Mycobacterium tuberculosis Ribokinase RbsK 0.004 0.0514 1
Trypanosoma brucei adenosine transporter 2, putative 0.0084 0.1462 0.2063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.6528 0.6528
Echinococcus multilocularis geminin 0.0351 0.7135 0.7135
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0485 1 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0311 0.3041
Leishmania major ribokinase, putative 0.004 0.0514 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0514 0.0378
Trypanosoma cruzi nucleoside transporter-like, putative 0.0084 0.1462 0.2063
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0064 0.1022 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1083 0.1083
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0064 0.1022 0.1442
Leishmania major tagatose-6-phosphate kinase-like protein 0.004 0.0514 0.0725
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3872 0.5427
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0485 1 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0084 0.1462 0.2063
Loa Loa (eye worm) hypothetical protein 0.0349 0.709 0.709
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0064 0.1022 0.0894
Trypanosoma brucei adenosine transporter 2, putative 0.0084 0.1462 0.2063
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0064 0.1022 0.0894
Loa Loa (eye worm) TAR-binding protein 0.0197 0.3872 0.3872
Loa Loa (eye worm) hypothetical protein 0.0485 1 1
Trichomonas vaginalis ribokinase, putative 0.004 0.0514 0.0378
Loa Loa (eye worm) hypothetical protein 0.0485 1 1
Entamoeba histolytica nucleoside transporter, putative 0.0084 0.1462 0.134
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0311 0.0439
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0141 0.0199
Trypanosoma brucei adenosine transporter, putative 0.0084 0.1462 0.2063
Schistosoma mansoni hypothetical protein 0.0144 0.2725 0.3819
Echinococcus multilocularis importin subunit beta 1 0.003 0.0311 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.414 0.414
Trypanosoma brucei unspecified product 0.0084 0.1462 0.2063
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.2205 0.3091
Toxoplasma gondii nucleoside transporter protein 0.0084 0.1462 0.2063
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.414 0.414
Giardia lamblia Ribokinase 0.004 0.0514 0.0378
Loa Loa (eye worm) STAT protein 0.013 0.243 0.243
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0141 0.0141
Brugia malayi TAR-binding protein 0.0197 0.3872 0.3872
Leishmania major putative PfkB family sugar kinase 0.004 0.0514 0.0725
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0064 0.1022 0.1442
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3872 0.5427
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1022 0.0894
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0084 0.1462 0.2063
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0084 0.1462 0.134
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0084 0.1462 0.2063
Entamoeba histolytica fructokinase, putative 0.004 0.0514 0.0378
Echinococcus granulosus snurportin 1 0.0322 0.6528 0.6528
Brugia malayi follicle stimulating hormone receptor 0.0235 0.4677 0.4677
Loa Loa (eye worm) hypothetical protein 0.0066 0.1083 0.1083
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0141 0.0141
Trypanosoma brucei purine nucleoside transporter 0.0084 0.1462 0.2063
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2175 0.2175
Brugia malayi Muscleblind-like protein 0.018 0.3509 0.3509
Schistosoma mansoni topbp1 0.0064 0.1022 0.1433
Schistosoma mansoni equilibrative nucleoside transporter 0.0084 0.1462 0.205
Trypanosoma cruzi nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Loa Loa (eye worm) hypothetical protein 0.0064 0.1022 0.1022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0141 0.0199
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0141 0.0199
Schistosoma mansoni hypothetical protein 0.0066 0.1083 0.1518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1083 0.1083
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.004 0.0514 0.0378
Trypanosoma brucei adenosine transporter 2 0.0084 0.1462 0.2063
Schistosoma mansoni hypothetical protein 0.0119 0.2205 0.3091
Trypanosoma brucei adenosine transporter, putative 0.0084 0.1462 0.2063
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0064 0.1022 0.5
Leishmania major nucleobase transporter 0.0084 0.1462 0.2063
Trypanosoma brucei ribokinase, putative 0.004 0.0514 0.0725
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0084 0.1462 0.134
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2175 0.2175
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0189 0.0049
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0401 0.8206 0.8206
Trypanosoma cruzi FHA domain containing protein, putative 0.0064 0.1022 0.1442
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.004 0.0514 1
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0485 1 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0064 0.1022 0.1022
Trypanosoma brucei adenosine transporter 2, putative 0.0084 0.1462 0.2063
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1083 0.1083
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.2725 0.2725
Onchocerca volvulus 0.0064 0.1022 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3872 0.5427
Echinococcus multilocularis GPCR, family 2 0.0066 0.1083 0.1083
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0189 0.0049
Leishmania major tagatose-6-phosphate kinase-like protein 0.004 0.0514 0.0725
Entamoeba histolytica hypothetical protein 0.0064 0.1022 0.0894
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0064 0.1022 0.0894
Echinococcus multilocularis ribokinase 0.004 0.0514 0.0514
Trypanosoma brucei adenosine transporter 2, putative 0.0084 0.1462 0.2063
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3872 0.5427
Chlamydia trachomatis DNA ligase 0.0064 0.1022 0.5
Entamoeba histolytica ribokinase, putative 0.004 0.0514 0.0378
Echinococcus multilocularis muscleblind protein 1 0.018 0.3509 0.3509
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0485 1 1
Trypanosoma cruzi ribokinase, putative 0.004 0.0514 0.0725
Echinococcus granulosus equilibrative nucleoside transporter 0.0485 1 1
Echinococcus granulosus geminin 0.0351 0.7135 0.7135
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3872 0.5427
Brugia malayi hypothetical protein 0.0064 0.1022 0.1022
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0485 1 1
Brugia malayi hypothetical protein 0.0119 0.2205 0.2205
Loa Loa (eye worm) hypothetical protein 0.018 0.3509 0.3509
Onchocerca volvulus 0.0309 0.6244 0.6041
Echinococcus granulosus ribokinase 0.004 0.0514 0.0514
Entamoeba histolytica hypothetical protein 0.0119 0.2205 0.2094
Echinococcus granulosus GPCR family 2 0.0066 0.1083 0.1083
Brugia malayi hypothetical protein 0.0485 1 1
Trypanosoma brucei ribokinase, putative 0.004 0.0514 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1022 0.0894
Trypanosoma brucei nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0084 0.1462 0.2063
Schistosoma mansoni adenosine kinase 0.0349 0.709 0.9936
Schistosoma mansoni ran 0.0022 0.0141 0.0198
Leishmania major nucleoside transporter 1, putative 0.0084 0.1462 0.2063
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.3872 0.3872
Trypanosoma brucei unspecified product 0.0084 0.1462 0.2063
Loa Loa (eye worm) hypothetical protein 0.004 0.0514 0.0514
Leishmania major adenosine kinase-like protein 0.004 0.0514 0.0725
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.004 0.0514 0.0514
Schistosoma mansoni importin beta-1 0.003 0.0311 0.0436
Echinococcus granulosus tar DNA binding protein 0.0197 0.3872 0.3872
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0141 0.1382
Echinococcus multilocularis nibrin 0.0064 0.1022 0.1022
Plasmodium falciparum importin beta, putative 0.003 0.0311 0.3041
Trypanosoma brucei adenosine kinase, putative 0.0349 0.709 1
Trypanosoma cruzi adenosine kinase, putative 0.0349 0.709 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0064 0.1022 0.0894

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.