Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4098 | 0.4098 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1888 | 0.1888 |
Onchocerca volvulus | Arrow homolog | 0.0005 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1661 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4098 | 0.4098 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4098 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1888 | 0.5 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1888 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1888 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1888 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1888 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1888 | 0.1888 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0005 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1888 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4098 | 0.4098 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1888 | 0.1888 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4098 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1888 | 0.1888 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1888 | 0.4608 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4098 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1888 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4098 | 0.4098 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1661 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4098 | 0.4098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4098 | 0.4098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4098 | 0.4098 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4098 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Brugia malayi | Inositol-1 | 0.0038 | 0.1888 | 0.4608 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1888 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4098 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1888 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4098 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1888 | 0.5 |
Onchocerca volvulus | Terribly reduced optic lobes homolog | 0.0005 | 0 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1888 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.