Detailed information for compound 1259192

Basic information

Technical information
  • TDR Targets ID: 1259192
  • Name: N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide
  • MW: 295.379 | Formula: C18H21N3O
  • H donors: 1 H acceptors: 1 LogP: 2.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CN1CCN(CC1)c1ccccc1
  • InChi: 1S/C18H21N3O/c22-18(19-16-7-3-1-4-8-16)15-20-11-13-21(14-12-20)17-9-5-2-6-10-17/h1-10H,11-15H2,(H,19,22)
  • InChiKey: ATZVQEGCJAMKAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-2-(4-phenyl-1-piperazinyl)acetamide
  • N-phenyl-2-(4-phenylpiperazin-1-yl)ethanamide
  • T5387383

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0009 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0162 0.0162
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0162 0.0167
Loa Loa (eye worm) Smad1 0.0009 0.0018 0.0018
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.2275 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0744 0.4987
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0747 0.0008
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0169 0.0174
Brugia malayi nuclear hormone receptor 0.0012 0.0162 0.0162
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.3855 0.3855
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0018 0.0019
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0018 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0162 0.0162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0744 0.0744
Schistosoma mansoni thyroid hormone receptor 0.0157 0.9348 0.9348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0018 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0169 0.0169
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.3855 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.2535 0.2612
Brugia malayi MH2 domain containing protein 0.0009 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Schistosoma mansoni Smad4 0.0009 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0162 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0162 0.0167
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.8135 0.8135
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.2535 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0744 0.0744
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0162 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0744 0.2731
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0162 0.0162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0162 0.0162
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus multilocularis smad 0.0009 0.0018 0.0018
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.1237 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0162 0.0162
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0162 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.3855 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0744 0.0744
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0744 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.2535 0.6333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.1237 1
Echinococcus multilocularis Smad4 0.0009 0.0018 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.8135 0.8135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0162 0.0162
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0983 0.7623
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.3855 1
Schistosoma mansoni thyroid hormone receptor 0.0157 0.9348 0.9348
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.1237 0.1237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0162 0.0162
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0744 0.0744
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0162 0.0162
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0169 0.0169
Schistosoma mansoni smad 0.0009 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1237 0.4881
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0744 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Schistosoma mansoni coup transcription factor 0.0012 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0254 0.1002
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0018 0.0018
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.2535 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0162 0.0162
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Echinococcus granulosus Smad4 0.0009 0.0018 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.3855 0.3855
Toxoplasma gondii FATC domain-containing protein 0.0029 0.1237 0.273
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0018 0.0018
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0744 0.0767
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0162 0.0162
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0162 0.0167
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.1237 0.1237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0162 0.0162
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0162 0.0162
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.2275 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0018 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.3855 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.3855 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0162 0.0167
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0744 0.4987
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0744 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0169 0.0169
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0744 0.0744
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0162 0.0162
Brugia malayi Smad1 0.0009 0.0018 0.0018
Echinococcus granulosus smad 0.0009 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0254 0.0254
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.3855 0.3973
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Loa Loa (eye worm) acetyltransferase 0.0167 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0744 0.4987
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0162 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.9348 0.9348
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.3855 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus granulosus serine protein kinase ATM 0.0029 0.1237 0.1275
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0744 0.0767
Brugia malayi MH1 domain containing protein 0.0009 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0145 0.861 0.861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0162
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0744 0.0744
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.3855 0.3855
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0162 0.0162
Brugia malayi MH2 domain containing protein 0.0009 0.0018 0.0018
Brugia malayi MH2 domain containing protein 0.0137 0.8135 0.8135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0162 0.0162
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0162 0.0167
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.2535 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.2535 0.6333
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0018 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0162 0.0162
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.861 0.8873
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0744 0.4987
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.2275 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0162 0.0162
Brugia malayi nuclear receptor NHR-88 0.0012 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0162 0.0162
Schistosoma mansoni smad1 5 8 and 0.0009 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.9703 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.861 0.861
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0744 0.0744
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0744 0.2731
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0744 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0254 0.1002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0744 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Loa Loa (eye worm) hypothetical protein 0.0025 0.0983 0.0983
Brugia malayi ecdysteroid receptor 0.0012 0.0162 0.0162
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0744 0.1362
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0162 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Brugia malayi MH1 domain containing protein 0.0009 0.0018 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Entamoeba histolytica hypothetical protein 0.0029 0.1237 0.5071
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0162 0.0162
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0162 0.0162
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0744 0.5386
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0744 0.5386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.1237 0.1237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0162 0.0162
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0162 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0162 0.0167
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0747 0.541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0169 0.0666
Onchocerca volvulus 0.0012 0.0162 0.5
Brugia malayi steroid hormone receptor 0.0012 0.0162 0.0162
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0162 0.0162
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0162 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0744 0.2936

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at human FPR1 expressed in RBL-2H3 cells assessed as induction of calcium mobilization ChEMBL. 20870313
Activity (functional) Agonist activity at human FPR2 expressed in RBL-2H3 cells assessed as induction of calcium mobilization ChEMBL. 20870313

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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