Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.382 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0778 | 0.1033 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.2898 | 0.7356 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.382 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.0743 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.2898 | 0.2985 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.1301 | 0.1271 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0778 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.382 | 0.4283 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.7944 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0018 | 0.0778 | 0.005 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0533 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.2898 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.2898 | 0.7356 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0778 | 0.1033 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0333 | 0.0333 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0778 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.382 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.1301 | 0.2774 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.012 | 0.7054 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.012 | 0.7054 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.012 | 0.7054 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.012 | 0.7054 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.788 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0778 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.2898 | 0.3369 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.0778 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0778 | 0.1275 |
Mycobacterium tuberculosis | Probable reductase | 0.012 | 0.7054 | 0.8837 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0754 | 0.1974 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0333 | 0.0333 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0778 | 0.1033 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.2898 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0013 | 0.0479 | 0.0569 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0778 | 0.3185 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0778 | 0.1033 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.382 | 1 |
Leishmania major | trypanothione reductase | 0.0053 | 0.2898 | 0.7195 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0018 | 0.0778 | 0.005 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0778 | 0.1733 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0778 | 0.1275 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.2898 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0778 | 0.1033 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.2898 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.1301 | 0.3771 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.382 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.0743 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.382 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.2898 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.2898 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0018 | 0.0778 | 0.1733 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.1301 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.0778 | 0.2036 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0018 | 0.0778 | 0.1733 |
Brugia malayi | glutathione reductase | 0.0053 | 0.2898 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.1301 | 1 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0778 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.788 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0013 | 0.0479 | 0.0569 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0778 | 0.0743 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0778 | 0.3185 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0778 | 0.0778 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.788 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0018 | 0.0778 | 0.1733 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.1301 | 0.2774 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.0778 | 0.2036 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.382 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.2898 | 0.7587 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.382 | 0.382 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.382 | 0.382 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0778 | 0.0743 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0018 | 0.0778 | 0.1733 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.0954 | 0.0954 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0778 | 0.1033 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.2898 | 0.3369 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0333 | 0.0873 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.1101 | 0.2991 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.2898 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0333 | 0.0873 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.788 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.012 | 0.7054 | 0.8837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30.8 % | Inhibition of His6x-tagged recombinant sphingosine kinase 1 expressed in HEK293 cells at 10.7 uM | ChEMBL. | 21050755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.