Detailed information for compound 1259717

Basic information

Technical information
  • TDR Targets ID: 1259717
  • Name: 4-chloro-N-[3-methyl-1-oxo-1-(oxolan-2-ylmeth ylamino)butan-2-yl]benzamide
  • MW: 338.829 | Formula: C17H23ClN2O3
  • H donors: 2 H acceptors: 2 LogP: 2.94 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)NC(C(=O)NCC1CCCO1)C(C)C
  • InChi: 1S/C17H23ClN2O3/c1-11(2)15(17(22)19-10-14-4-3-9-23-14)20-16(21)12-5-7-13(18)8-6-12/h5-8,11,14-15H,3-4,9-10H2,1-2H3,(H,19,22)(H,20,21)
  • InChiKey: JJCGBDPBBDXXBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-[2-methyl-1-(tetrahydrofuran-2-ylmethylcarbamoyl)propyl]benzamide
  • 4-chloro-N-[2-methyl-1-[oxo-(2-tetrahydrofuranylmethylamino)methyl]propyl]benzamide
  • 4-chloro-N-[2-methyl-1-(tetrahydrofurfurylcarbamoyl)propyl]benzamide
  • T5275128

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Importin beta-1 subunit 0.0035 0.0527 0.0771
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0186 0.0186
Entamoeba histolytica Ran family GTPase 0.0026 0.0268 0.5279
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0186 1
Schistosoma mansoni ap endonuclease 0.0023 0.0186 0.0186
Trichomonas vaginalis ran, putative 0.0026 0.0268 0.0123
Echinococcus multilocularis tar DNA binding protein 0.0128 0.3147 0.3147
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0527 1
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.3147 0.4608
Schistosoma mansoni importin beta-1 0.0035 0.0527 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Loa Loa (eye worm) TAR-binding protein 0.0128 0.3147 0.3147
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0342 0.0234
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0186 0.3537
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0268 0.5094
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0268 0.5094
Echinococcus granulosus importin subunit beta 1 0.0035 0.0527 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3147 0.3147
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Toxoplasma gondii exonuclease III APE 0.0023 0.0186 0.3537
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0268 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0186 0.0273
Plasmodium falciparum importin beta, putative 0.0035 0.0527 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0342 1
Brugia malayi RNA, U transporter 1 0.0099 0.2332 0.3415
Echinococcus multilocularis snurportin 1 0.0372 1 1
Schistosoma mansoni ran 0.0026 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0527 0.0527
Leishmania major GTP-binding protein, putative 0.0026 0.0268 0.7854
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Schistosoma mansoni ran 0.0026 0.0268 0.0268
Echinococcus granulosus tar DNA binding protein 0.0128 0.3147 0.3147
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3147 0.3147
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Loa Loa (eye worm) RNA binding protein 0.0128 0.3147 0.3147
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0186 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0268 0.5094
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0268 0.7854
Entamoeba histolytica hypothetical protein 0.0028 0.0342 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0342 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.6829 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0186 0.3537
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0268 0.0268
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0186 0.5
Brugia malayi RNA binding protein 0.0128 0.3147 0.4608
Plasmodium vivax importin-beta 2, putative 0.0035 0.0527 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3147 0.3147
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4583 0.6618
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.6829 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0527 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4325 0.6231
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3147 0.3147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0186 0.5454
Brugia malayi TAR-binding protein 0.0128 0.3147 0.4608
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0186 0.5454
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0186 0.5454
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0268 0.0268
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0268 0.0268
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0268 0.7854
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.3147 0.3147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0527 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0186 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3147 0.3147
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.4325 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4583 0.6618
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0268 0.0393
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0186 0.5
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0268 0.5094
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0527 0.0527
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.6829 0.6829
Schistosoma mansoni hypothetical protein 0.0372 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0186 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.0186 0.0186
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0186 0.3537

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1917 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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