TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 474.085 | Formula: C23H28ClN5S2
H donors: 0 H acceptors: 3 LogP: 5.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)C1(CCN(C1)CCCSc1nnc(n1C)c1sc(nc1C)C)CC2
InChi: 1S/C23H28ClN5S2/c1-15-20(31-16(2)25-15)21-26-27-22(28(21)3)30-12-4-10-29-11-9-23(14-29)8-7-17-5-6-18(24)13-19(17)23/h5-6,13H,4,7-12,14H2,1-3H3
InChiKey: HXLACIAZOWDZEP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D3	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	dopamine receptor D3	400 aa	392 aa	19.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0023	0.1079	0.1079
Schistosoma mansoni	amine GPCR	0.0023	0.1079	0.1079
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0232	0.0194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.7852	1
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0232	0.0194
Plasmodium vivax	glutathione reductase, putative	0.0048	0.2803	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.1079	0.1707
Brugia malayi	Melatonin receptor type 1A	0.0023	0.1079	0.1707
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0232	0.0194
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0023	0.1079	0.1707
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2875	0.2875
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0232	0.0194
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0654	0.0948
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.2593	0.4411
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0612	0.0872
Echinococcus granulosus	fmrfamide receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0232	0.0194
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.1079	0.1707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0023	0.1079	0.1707
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	GPCR family 2	0.0016	0.0612	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0232	0.0232
Onchocerca volvulus		0.0023	0.1079	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0612	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.1079	0.1707
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0023	0.1079	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.1079	0.1707
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.1079	0.1707
Brugia malayi	nuclear receptor NHR-88	0.001	0.0232	0.0194
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.2803	0.4787
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.1079	0.1707
Trypanosoma brucei	trypanothione reductase	0.0048	0.2803	0.4241
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0232	0.0194
Schistosoma mansoni	biogenic amine receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.1079	0.1707
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.1079	0.1079
Schistosoma mansoni	hypothetical protein	0.0023	0.1079	0.1079
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0654	0.0654
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.2593	0.4411
Onchocerca volvulus		0.0023	0.1079	1
Schistosoma mansoni	hypothetical protein	0.0034	0.1884	0.1884
Brugia malayi	Dopamine receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0232	0.0232
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.009	0.572	1
Mycobacterium tuberculosis	Probable reductase	0.0109	0.7015	0.8837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0232	0.0194
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.1079	0.1079
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0232	0.0194
Brugia malayi	neuropeptide F receptor	0.0023	0.1079	0.1707
Brugia malayi	Serotonin receptor	0.0023	0.1079	0.1707
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0232	0.0194
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0232	0.0194
Onchocerca volvulus		0.0023	0.1079	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.1079	0.1707
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	dual specificity	0.009	0.572	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0232	0.0194
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.239	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Schistosoma mansoni	amine GPCR	0.0023	0.1079	0.1079
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0406	0.0406
Brugia malayi	Serotonin receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Thioredoxin reductase	0.0048	0.2803	0.4787
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0654	0.5
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.2981	0.5105
Brugia malayi	nuclear hormone receptor	0.001	0.0232	0.0194
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.1079	0.1079
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0232	0.0194
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.7015	0.8837
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	hypothetical protein	0.0016	0.0612	0.0612
Brugia malayi	neuropeptide F receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.2803	0.2985
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.1079	0.1707
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.005	0.2981	0.5105
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	g protein coupled receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0232	0.0194
Brugia malayi	G-protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.1079	0.1707
Schistosoma mansoni	amine GPCR	0.0023	0.1079	0.1079
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.1079	0.1079
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.1079	0.1079
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0654	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.1079	0.1707
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2875	0.2875
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.572	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0023	0.1079	0.1707
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0232	0.0194
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0232	0.0194
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0654	0.0948
Brugia malayi	sulfakinin receptor protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.1079	0.1707
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.7852	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0612	0.0872
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.1079	0.1707
Entamoeba histolytica	protein kinase, putative	0.009	0.572	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.1079	0.1707
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.1079	0.1707
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus granulosus	neuropeptide receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.1079	0.1079
Brugia malayi	putative neuropeptide receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.1079	0.1707
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0232	0.0232
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0612	0.0872
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0654	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.572	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.239	1
Echinococcus multilocularis	somatostatin receptor	0.0023	0.1079	0.1707
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.7015	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0232	0.0232
Onchocerca volvulus		0.0023	0.1079	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.009	0.572	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0124	0.0124
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.2981	0.5105
Brugia malayi	Protein kinase domain containing protein	0.009	0.572	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0023	0.1079	1
Echinococcus multilocularis	serotonin receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.1079	0.1707
Schistosoma mansoni	hypothetical protein	0.0016	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.1079	0.1707
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.1079	0.1707
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0406	0.0505
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.1079	0.1707
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.2981	0.5105
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	myosin xvIII	0.0023	0.1079	0.1079
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0232	0.0232
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.1079	0.1079
Brugia malayi	glutathione reductase	0.0048	0.2803	0.4787
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.1079	0.1707
Plasmodium falciparum	thioredoxin reductase	0.0048	0.2803	1
Brugia malayi	larval opioid receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0406	0.0505
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.1079	0.1707
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0654	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0232	0.0194
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0654	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.1079	0.1707
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.7852	1
Echinococcus granulosus	allatostatin A receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0232	0.0194
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Brugia malayi	Dopamine receptor protein 2	0.0023	0.1079	0.1707
Brugia malayi	steroid hormone receptor	0.001	0.0232	0.0194
Brugia malayi	Dopamine receptor protein 1	0.0023	0.1079	0.1707
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.7015	0.8837
Plasmodium falciparum	glutathione reductase	0.0048	0.2803	1
Schistosoma mansoni	amine GPCR	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.2803	0.4787
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0232	0.0194
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0232	0.0194
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.1079	0.1707
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.1079	0.1079
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0232	0.0232
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	histamine h1 receptor	0.0023	0.1079	0.1079
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.1079	0.1707
Echinococcus granulosus	serotonin receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	coup transcription factor	0.001	0.0232	0.0232
Onchocerca volvulus		0.0023	0.1079	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Onchocerca volvulus		0.0023	0.1079	1
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0654	0.234
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0406	0.0406
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.7015	0.8837
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0654	0.234
Schistosoma mansoni	hypothetical protein	0.0023	0.1079	0.1079
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	ecdysteroid receptor	0.001	0.0232	0.0194
Echinococcus granulosus	sex peptide receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	neuropeptide receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	g protein coupled receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0232	0.0232
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Treponema pallidum	NADH oxidase	0.0016	0.0654	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2186	0.3685
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Echinococcus granulosus	orexin receptor type 2	0.0023	0.1079	0.1707
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.1079	0.1707
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0124	0.0124
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.7852	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.1079	0.1707
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0232	0.0194
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0232	0.0194
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0232	0.0194
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0124	0.0124
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0232	0.0194
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.572	0.572
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.1079	0.1079
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0352	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	g protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.1079	0.1707
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.1079	0.1079
Onchocerca volvulus		0.0023	0.1079	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.2593	0.4411
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0232	0.0194
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0232	0.0194
Onchocerca volvulus		0.0023	0.1079	1
Brugia malayi	G-protein coupled receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0232	0.0194
Brugia malayi	RE15519p	0.0023	0.1079	0.1707
Schistosoma mansoni	hypothetical protein	0.0016	0.0612	0.0612
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	neuropeptide receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.1079	0.1079
Schistosoma mansoni	hypothetical protein	0.0016	0.0612	0.0612
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5688	0.9943
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0352	0.0407
Schistosoma mansoni	neuropeptide receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	somatostatin receptor	0.0023	0.1079	0.1707
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0612	0.0872
Leishmania major	trypanothione reductase	0.0048	0.2803	0.4241
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0232	0.0232
Schistosoma mansoni	opsin-like receptor	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.572	1
Schistosoma mansoni	amine GPCR	0.0023	0.1079	0.1079
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.1079	0.1707
Entamoeba histolytica	protein kinase, putative	0.009	0.572	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0232	0.0232
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.1079	0.1707
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0612	0.0872
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0232	0.0194
Schistosoma mansoni	neuropeptide receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.1079	0.1707
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0612	0.0872
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.1079	0.1079
Echinococcus multilocularis	serotonin receptor	0.0023	0.1079	0.1707
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.1079	0.1707
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.1079	0.1079
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.1079	0.1079
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0654	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.1079	0.1707
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0654	0.0948
Brugia malayi	GnHR receptor homolog	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.2803	0.4241
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.1079	0.1079
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0654	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.1079	0.1079
Echinococcus multilocularis	sex peptide receptor	0.0023	0.1079	0.1707
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.2803	1
Schistosoma mansoni	neuropeptide receptor	0.0023	0.1079	0.1079
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0406	0.0505
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.2593	0.4411
Schistosoma mansoni	biogenic amine receptor	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0612	0.0872
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0232	0.0232
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0406	0.0505
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1884	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0232	0.0194
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0232	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5688	0.9943
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.1079	0.1707
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0232	0.0194
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.1079	0.1707
Schistosoma mansoni	biogenic amine receptor	0.0023	0.1079	0.1079
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0612	0.0872
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.1079	0.1707
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.1079	0.1707
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0232	0.0194
Loa Loa (eye worm)	glutathione reductase	0.0048	0.2803	0.4787
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0406	0.0505
Brugia malayi	ORL1-like opioid receptor	0.0023	0.1079	0.1707
Brugia malayi	G protein-coupled receptor	0.0023	0.1079	0.1707
Brugia malayi	hypothetical protein	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Brugia malayi	AKH receptor	0.0023	0.1079	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.1079	0.1079
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.7015	0.8837
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.009	0.572	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.2803	0.4787
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.1079	0.1707
Echinococcus multilocularis	dual specificity	0.009	0.572	1
Onchocerca volvulus		0.0023	0.1079	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0232	0.0194
Schistosoma mansoni	opsin-like receptor	0.0023	0.1079	0.1079
Schistosoma mansoni	opsin-like receptor	0.0023	0.1079	0.1079
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0406	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1079	0.1707
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0124	0.0124
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1884	0.3146
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0232	0.0194
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.1079	0.1707
Onchocerca volvulus		0.0023	0.1079	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.1079	0.1079
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.1079	0.1707
Toxoplasma gondii	thioredoxin reductase	0.0048	0.2803	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0232	0.0194
Entamoeba histolytica	hypothetical protein	0.009	0.572	0.5
Schistosoma mansoni	hypothetical protein	0.0023	0.1079	0.1079
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.1079	0.1707
Schistosoma mansoni	adenoreceptor	0.0023	0.1079	0.1079

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6	Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay	ChEMBL.	20839775
Ki (functional)	= 6.5	Antagonist activity at human dopamine D2L receptor expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL.	20839775
Ki (functional)	= 7.5	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL.	20839775

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1258834

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1259926