Detailed information for compound 1260132

Basic information

Technical information
  • TDR Targets ID: 1260132
  • Name: 2-chloro-N-pyridin-2-yl-5-(1,2,4-triazol-4-yl )benzamide
  • MW: 299.715 | Formula: C14H10ClN5O
  • H donors: 1 H acceptors: 4 LogP: 1.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)n1cnnc1)Nc1ccccn1
  • InChi: 1S/C14H10ClN5O/c15-12-5-4-10(20-8-17-18-9-20)7-11(12)14(21)19-13-3-1-2-6-16-13/h1-9H,(H,16,19,21)
  • InChiKey: QKCBITZDTBBHAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-N-(2-pyridyl)-5-(1,2,4-triazol-4-yl)benzamide
  • SMR000079370
  • SDCCGMLS-0028719.P002
  • ZINC01075616
  • 2-chloro-N-2-pyridinyl-5-(4H-1,2,4-triazol-4-yl)benzamide
  • MLS000065970

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ferritin light chain 0.0008 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0474 0.0639
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0537 0.0733
Schistosoma mansoni intermediate filament proteins 0.0027 0.0486 0.0486
Schistosoma mansoni ferritin 0.0008 0.0028 0.0028
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0143 0.0143
Echinococcus granulosus lamin dm0 0.0027 0.0486 0.0486
Echinococcus granulosus tar DNA binding protein 0.0128 0.2937 0.2937
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2937 0.2937
Schistosoma mansoni ferritin 0.0008 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0129
Loa Loa (eye worm) hypothetical protein 0.0016 0.0215 0.0255
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1241 0.1782
Schistosoma mansoni ferritin light chain 0.0008 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0035 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0143 0.0147
Schistosoma mansoni cpg binding protein 0.0029 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0286 0.6776 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2937 0.2937
Echinococcus granulosus expressed protein 0.0008 0.0028 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1176 0.5
Echinococcus multilocularis lamin 0.0027 0.0486 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1063 0.1518
Echinococcus granulosus GPCR family 2 0.0016 0.0215 0.0215
Echinococcus granulosus lamin 0.0027 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0051 0.1063 0.1514
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0215 0.0215
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0178 0.02
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2937 0.4301
Loa Loa (eye worm) hypothetical protein 0.005 0.104 0.148
Schistosoma mansoni hypothetical protein 0.0016 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0016 0.0215 0.0215
Brugia malayi hypothetical protein 0.0286 0.6776 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2937 0.2937
Echinococcus multilocularis tumor protein p63 0.0342 0.8139 0.8139
Schistosoma mansoni lamin 0.0027 0.0486 0.0486
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0215 0.0215
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0215 0.0259
Schistosoma mansoni hypothetical protein 0.0016 0.0215 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0215 0.0215
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0215 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2937 0.2937
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0578
Echinococcus multilocularis geminin 0.0165 0.3833 0.3833
Onchocerca volvulus 0.0029 0.0537 0.0674
Brugia malayi CXXC zinc finger family protein 0.0029 0.0537 0.0737
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0215 0.0215
Echinococcus multilocularis lamin dm0 0.0027 0.0486 0.0486
Echinococcus multilocularis GPCR, family 2 0.0016 0.0215 0.0215
Schistosoma mansoni apoferritin-2 0.0008 0.0028 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1063 0.1514
Echinococcus granulosus geminin 0.0165 0.3833 0.3833
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0215 0.0255
Echinococcus multilocularis expressed protein 0.0008 0.0028 0.0028
Schistosoma mansoni cellular tumor antigen P53 0.005 0.104 0.104
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2937 0.2937
Schistosoma mansoni survival motor neuron protein 0.0058 0.1241 0.1241
Brugia malayi TAR-binding protein 0.0128 0.2937 0.4301
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1063 0.1518
Schistosoma mansoni hypothetical protein 0.0165 0.3833 0.3833
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0028 0.5
Echinococcus multilocularis cpg binding protein 0.0031 0.0578 0.0578
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0143 0.0143
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0178 0.0204
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0486 0.0657
Schistosoma mansoni lamin 0.0027 0.0486 0.0486
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0028 0.5
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2937 0.4298
Schistosoma mansoni ferritin 0.0008 0.0028 0.0028
Echinococcus granulosus ferritin 0.0008 0.0028 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0486 0.0661
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0028 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1338 0.1338
Loa Loa (eye worm) RNA binding protein 0.0128 0.2937 0.4298
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.067 0.0935
Schistosoma mansoni ferritin 0.0008 0.0028 0.0028
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6776 0.6776
Brugia malayi RNA binding protein 0.0128 0.2937 0.4301
Brugia malayi intermediate filament protein 0.0027 0.0486 0.0661
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0129
Onchocerca volvulus 0.0058 0.1241 1
Echinococcus multilocularis ferritin 0.0008 0.0028 0.0028
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0028 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.1241 0.1241
Schistosoma mansoni hypothetical protein 0.0418 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0215 0.0215
Echinococcus multilocularis musashi 0.0027 0.0486 0.0486
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0028 0.5
Echinococcus granulosus intermediate filament protein 0.0027 0.0486 0.0486
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Echinococcus granulosus tumor protein p63 0.0342 0.8139 0.8139
Echinococcus multilocularis dnaJ subfamily B 0.0418 1 1
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0028 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6776 0.6776
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2937 0.4298
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0486 0.0657
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0035 0.067 0.0931
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0486 0.0657
Trichomonas vaginalis ferritin, putative 0.0008 0.0028 0.5
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2937 0.2937
Schistosoma mansoni hypothetical protein 0.0165 0.3833 0.3833
Echinococcus granulosus cpg binding protein 0.0031 0.0578 0.0578
Onchocerca volvulus 0.005 0.104 0.7335
Schistosoma mansoni apoferritin-2 0.0008 0.0028 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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