Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0108 | 0.0949 | 0.0949 |
Trypanosoma brucei | hexokinase | 0.0756 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0756 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Echinococcus granulosus | hexokinase | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0756 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0756 | 1 | 0.5 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0108 | 0.0949 | 0.0949 |
Trypanosoma brucei | hexokinase, putative | 0.0756 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0756 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0756 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0756 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0756 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0756 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0474 | 0.6065 | 0.4604 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0472 | 0.6027 | 0.5937 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Onchocerca volvulus | 0.0756 | 1 | 1 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Echinococcus multilocularis | hexokinase | 0.0756 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0756 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0756 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0756 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0756 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0756 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.2797 | 0.0123 |
Plasmodium vivax | hexokinase, putative | 0.0756 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0756 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Brugia malayi | hexokinase type II | 0.024 | 0.2797 | 0.0123 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0108 | 0.0949 | 0.0746 |
Trypanosoma brucei | hexokinase | 0.0756 | 1 | 0.5 |
Onchocerca volvulus | 0.0756 | 1 | 1 | |
Onchocerca volvulus | 0.0756 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.2797 | 0.0123 |
Trypanosoma cruzi | hexokinase, putative | 0.0756 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0756 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0474 | 0.6065 | 0.4604 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.6643 | 0.5396 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0061 | 0.0287 | 0.0287 |
Leishmania major | hexokinase, putative | 0.0756 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.