TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 571.654 | Formula: C30H32F3N3O3S
H donors: 2 H acceptors: 4 LogP: 6.19 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: N#C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)(C)C)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)S(=O)(=O)C
InChi: 1S/C30H32F3N3O3S/c1-29(2,3)27(28(37)35-24(19-34)18-20-8-6-5-7-9-20)36-26(30(31,32)33)23-12-10-21(11-13-23)22-14-16-25(17-15-22)40(4,38)39/h5-17,24,26-27,36H,18H2,1-4H3,(H,35,37)/t24-,26-,27+/m0/s1
InChiKey: RSRMHQDUXAJHOR-DOEKTCAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin F	Starlite/ChEMBL	References
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0505	0.0436
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Schistosoma mansoni	alpha-glucosidase	0.014	0.3875	0.747
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1903	0.7238
Loa Loa (eye worm)	fibroinase	0.0079	0.1903	0.271
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2555	0.3644
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0043	0.0736	0.2673
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0155	0.4364	0.8432
Plasmodium falciparum	pyruvate kinase	0.0099	0.2555	1
Onchocerca volvulus		0.0079	0.1903	0.7375
Giardia lamblia	Pyruvate kinase	0.0051	0.0987	0.2101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.1903	0.7375
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2665
Schistosoma mansoni	alpha glucosidase	0.0036	0.0505	0.085
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0547	0.0478
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0519	0.0878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.0736	0.2291
Echinococcus granulosus	cysteine protease	0.0043	0.0736	0.0668
Mycobacterium ulcerans	pyruvate kinase	0.0099	0.2555	1
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0878
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.013	0.0114
Echinococcus granulosus	pyruvate kinase	0.0099	0.2555	0.25
Plasmodium falciparum	carbonic anhydrase	0.0058	0.1202	0.4551
Echinococcus granulosus	cathepsin l1	0.0055	0.1107	0.1042
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0519	0.0102
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0155	0.4364	0.6239
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Schistosoma mansoni	hypothetical protein	0.007	0.1614	0.3029
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0683	0.2459
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.3919	0.7557
Loa Loa (eye worm)	pyruvate kinase-PB	0.0069	0.158	0.2247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.0714
Echinococcus multilocularis	cysteine protease	0.0079	0.1903	0.1844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0155	0.4364	0.8432
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1107	0.1569
Entamoeba histolytica	cysteine proteinase 2	0.0043	0.0736	0.1652
Echinococcus multilocularis	tumor protein p63	0.0329	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	pyruvate kinase 1	0.0099	0.2555	0.5311
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0099	0.2555	1
Schistosoma mansoni	carbonic anhydrase	0.0058	0.1202	0.2219
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0055	0.1107	0.1569
Mycobacterium ulcerans	monoamine oxidase	0.0023	0.0072	0.0284
Mycobacterium tuberculosis	Possible oxidoreductase	0.0023	0.0072	0.0284
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Echinococcus multilocularis	cysteine protease	0.0079	0.1903	0.1844
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0505	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0162	0.4609	0.659
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0505	0.1743
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.1614	0.1553
Plasmodium vivax	vivapain-3	0.0043	0.0736	0.2673
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0736	0.1304
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1429	0.1366
Echinococcus multilocularis	pyruvate kinase	0.0099	0.2555	0.25
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0058	0.1202	0.1705
Trypanosoma brucei	pyruvate kinase 1, putative	0.0099	0.2555	0.5311
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0519	0.0878
Onchocerca volvulus		0.0048	0.0896	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.1903	0.271
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0505	0.085
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0023	0.0072	0.0284
Echinococcus granulosus	cathepsin L	0.0043	0.0736	0.0668
Loa Loa (eye worm)	acetyltransferase	0.0141	0.3919	0.5601
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.1614	0.3029
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1903	0.3596
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.1903	0.1844
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0099	0.2555	0.4876
Loa Loa (eye worm)	inositol-1	0.0036	0.0519	0.0726
Brugia malayi	SWIRM domain containing protein	0.0023	0.0072	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0736	0.1037
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Brugia malayi	hypothetical protein	0.007	0.1614	0.2296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0736	0.0598
Schistosoma mansoni	alpha-glucosidase	0.014	0.3875	0.747
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0519	0.2033
Trichomonas vaginalis	pyruvate kinase, putative	0.0099	0.2555	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0519	0.1372
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1429	0.203
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0023	0.0072	0.0284
Echinococcus multilocularis	carbonic anhydrase II	0.0155	0.4364	0.4323
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0099	0.2555	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.0714
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Onchocerca volvulus		0.0094	0.2385	0.9318
Echinococcus granulosus	carbonic anhydrase II	0.0155	0.4364	0.4323
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.1107	0.4308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Toxoplasma gondii	cathepsin B	0.0068	0.1555	0.5975
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.1903	0.7375
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.013	0.0168
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus multilocularis	cathepsin b	0.018	0.5163	0.5127
Leishmania major	pyruvate kinase	0.0099	0.2555	0.5784
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0027	0.0196	0.3767
Echinococcus multilocularis	cathepsin L	0.0043	0.0736	0.0668
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1903	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0505	0.0706
Trypanosoma cruzi	cruzipain precursor, putative	0.0136	0.3748	0.722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Loa Loa (eye worm)	cathepsin B	0.0068	0.1555	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1903	1
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Echinococcus granulosus	pyruvate kinase	0.0099	0.2555	0.25
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.0714
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0519	0.18
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0683	0.2459
Plasmodium vivax	pyruvate kinase 2, putative	0.0051	0.0987	0.3686
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Mycobacterium ulcerans	dehydrogenase	0.0023	0.0072	0.0284
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0505	0.1312
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0023	0.0072	0.0284
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0099	0.2555	0.3644
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1107	0.1569
Brugia malayi	Inositol-1	0.0036	0.0519	0.0726
Plasmodium vivax	unspecified product	0.0025	0.013	0.0233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.0714
Loa Loa (eye worm)	cysteine protease	0.0079	0.1903	0.271
Echinococcus multilocularis	cathepsin b	0.018	0.5163	0.5127
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.057	0.0468
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0519	0.045
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0736	0.1304
Echinococcus multilocularis	pyruvate kinase	0.0099	0.2555	0.25
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Schistosoma mansoni	hypothetical protein	0.0051	0.0976	0.1775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Toxoplasma gondii	hypothetical protein	0.0058	0.1202	0.4551
Loa Loa (eye worm)	hypothetical protein	0.018	0.5163	0.7383
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0043	0.0736	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Plasmodium vivax	vivapain-2	0.0079	0.1903	0.7375
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Brugia malayi	cathepsin B-like cysteine proteinase	0.018	0.5163	0.7383
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0519	0.1372
Leishmania major	cysteine peptidase A (CPA)	0.0079	0.1903	0.4265
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0878
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1903	0.1844
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0505	0.0706
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Toxoplasma gondii	pyruvate kinase PyK1	0.0099	0.2555	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0043	0.0736	0.0668
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0683	0.2065
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0547	0.0478
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0155	0.4364	0.8432
Loa Loa (eye worm)	MH2 domain-containing protein	0.0236	0.6988	1
Plasmodium falciparum	pyruvate kinase 2	0.0051	0.0987	0.3686
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Onchocerca volvulus		0.0079	0.1903	0.7375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1107	0.3865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.1555	0.2913
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1903	0.7375
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	cathepsin L-like precursor	0.0055	0.1107	0.1569
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0395	0.1547
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0068	0.1555	0.2722
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0519	0.045
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.3919	0.3875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus granulosus	cathepsin b	0.018	0.5163	0.5127
Schistosoma mansoni	pyruvate kinase	0.0099	0.2555	0.4876
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1903	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0505	0.1312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.1903	0.271
Trypanosoma cruzi	cysteine protease, putative	0.0043	0.0736	0.1304
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1903	0.3596
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0099	0.2555	0.4876
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0781	0.1102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.1107	0.2033
Mycobacterium ulcerans	oxidoreductase	0.0023	0.0072	0.0284
Entamoeba histolytica	cysteine proteinase 1, putative	0.0043	0.0736	0.1652
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0037
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1429	0.3161
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0099	0.2555	0.3644
Loa Loa (eye worm)	transcription factor SMAD2	0.0236	0.6988	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.013	0.0168
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0023	0.0072	0.0284
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0896	0.1617
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0155	0.4364	0.6239
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1903	0.1844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Leishmania major	carbonic anhydrase-like protein	0.0155	0.4364	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0068	0.1555	0.2913
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Echinococcus granulosus	cathepsin l1	0.0079	0.1903	0.1844
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.003	0.0309	0.0424
Chlamydia trachomatis	pyruvate kinase	0.0099	0.2555	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0155	0.4364	1
Onchocerca volvulus		0.0079	0.1903	0.7375
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0519	0.1372
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0023	0.0072	0.0284
Trypanosoma cruzi	cysteine peptidase, putative	0.0043	0.0736	0.1304
Plasmodium vivax	pyruvate kinase, putative	0.0099	0.2555	1
Schistosoma mansoni	hypothetical protein	0.0058	0.1202	0.2219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0683	0.2065
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0781	0.1102
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.018	0.5163	1
Brugia malayi	hypothetical protein	0.0023	0.0072	0.0085
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0683	0.0615
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0068	0.1555	0.5764
Trichomonas vaginalis	pyruvate kinase, putative	0.0099	0.2555	1
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0736	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0025	0.013	0.0168
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1903	0.3596
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1903	0.271
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.3791	0.3745
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Loa Loa (eye worm)	ctsf protein	0.0079	0.1903	0.271
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0505	0.085
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0896	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0505	0.1008
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.013	0.0114
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Brugia malayi	amine oxidase, flavin-containing family protein	0.0023	0.0072	0.0085
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Giardia lamblia	Pyruvate kinase	0.0099	0.2555	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0058	0.1202	0.1705
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.057	0.2006
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0155	0.4364	0.6239
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Schistosoma mansoni	cathepsin s	0.0025	0.013	0.0114
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0162	0.4609	0.659
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.1041
Onchocerca volvulus		0.0079	0.1903	0.7375
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0519	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0155	0.4364	0.8432
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0395	0.1547
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0505	0.1312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1107	0.3865
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.1614	0.1553
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0683	0.2459
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1903	0.7375
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.3919	0.5601
Schistosoma mansoni	pyruvate kinase	0.0099	0.2555	0.4876
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0111	0.2952	0.5657
Entamoeba histolytica	pyruvate kinase, putative	0.0069	0.158	0.7692
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Onchocerca volvulus		0.0055	0.1107	0.4169
Echinococcus multilocularis	pyruvate kinase	0.0078	0.1876	0.1817
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0068	0.1555	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1429	0.6609
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2394
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Plasmodium vivax	vivapain-1	0.0043	0.0736	0.2673
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2665
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1429	0.203
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0505	0.0436
Echinococcus granulosus	cathepsin b	0.018	0.5163	0.5127
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Onchocerca volvulus		0.0079	0.1903	0.7375
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Echinococcus granulosus	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.1903	0.7375
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1429	0.2665
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1903	0.271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.013	0.0168
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1429	0.1366
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Onchocerca volvulus		0.0079	0.1903	0.7375
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Schistosoma mansoni	pyruvate kinase	0.0051	0.0987	0.1797
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Toxoplasma gondii	pyruvate kinase PyKII	0.0051	0.0987	0.3686
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.018	0.5163	1
Brugia malayi	MH2 domain containing protein	0.0236	0.6988	1
Plasmodium vivax	unspecified product	0.0043	0.0736	0.2673
Trypanosoma cruzi	major cysteine proteinase, putative	0.0075	0.1785	0.3364
Loa Loa (eye worm)	carbonic anhydrase 3	0.0155	0.4364	0.6239
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.0736	0.2291
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.158	0.2247
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0736	0.1037
Onchocerca volvulus		0.0079	0.1903	0.7375
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.1903	0.7375
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0058	0.1202	0.1705
Plasmodium vivax	vivapain-2	0.0079	0.1903	0.7375
Leishmania major	pyruvate kinase	0.0099	0.2555	0.5784
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0072	0.0284
Toxoplasma gondii	cathepsin CPL	0.0079	0.1903	0.7375

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 380 nM	Inhibition of Trypanosoma cruzi Cruzipain	ChEMBL.	21041084
IC50 (binding)	> 10000 nM	Inhibition of human Cat B in HepG2 cells	ChEMBL.	21041084
IC50 (binding)	> 10000 nM	Inhibition of human Cat F expressed in rabbit HIG82 cells	ChEMBL.	21041084
IC50 (binding)	> 10000 nM	Inhibition of human Cat L	ChEMBL.	21041084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1290418

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1261035