Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0191 | 0.0242 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0553 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0553 | 0.0401 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0553 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0553 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0535 | 0.0739 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0963 | 0.0434 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.724 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.2951 | 0.4076 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0553 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0553 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0553 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0553 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0535 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4163 | 0.4395 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0553 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.7886 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.2951 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.9228 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3391 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3818 | 0.4014 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0535 | 0.0739 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.3378 | 0.2991 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.