Detailed information for compound 1261560

Basic information

Technical information
  • TDR Targets ID: 1261560
  • Name: 1-[2-(4-bromophenoxy)ethoxy]-3-(propan-2-ylam ino)propan-2-ol hydrochloride
  • MW: 368.694 | Formula: C14H23BrClNO3
  • H donors: 2 H acceptors: 1 LogP: 2.99 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COCCOc1ccc(cc1)Br)CNC(C)C.Cl
  • InChi: 1S/C14H22BrNO3.ClH/c1-11(2)16-9-13(17)10-18-7-8-19-14-5-3-12(15)4-6-14;/h3-6,11,13,16-17H,7-10H2,1-2H3;1H
  • InChiKey: WKTZJDVXZGEHMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-bromophenoxy)ethoxy]-3-(isopropylamino)propan-2-ol hydrochloride
  • 1-[2-(4-bromophenoxy)ethoxy]-3-(isopropylamino)-2-propanol
  • MLS000698842
  • SMR000225357

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.1346 0.1455
Leishmania major ubiquitin-activating enzyme-like protein 0.0034 0.0113 0.0126
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0557 0.0805
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0366 0.0291
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0764 0.1676
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0764 0.118
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0161 0.0054
Schistosoma mansoni hypothetical protein 0.0038 0.0176 0.0072
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Trypanosoma cruzi DNA polymerase eta, putative 0.0117 0.1317 0.1422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0935 0.0948
Trichomonas vaginalis esterase, putative 0.0079 0.0764 0.0486
Entamoeba histolytica hypothetical protein 0.0038 0.0176 0.1304
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0476 0.053
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.06 0.0686
Plasmodium vivax ubiquitin activating enzyme, putative 0.0051 0.0366 0.3068
Brugia malayi ImpB/MucB/SamB family protein 0.0119 0.1346 0.154
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0161 0.013
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0764 0.111
Schistosoma mansoni ap endonuclease 0.0059 0.0476 0.0418
Loa Loa (eye worm) hypothetical protein 0.0051 0.0366 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1017
Loa Loa (eye worm) hypothetical protein 0.0469 0.6404 0.7326
Trypanosoma cruzi DNA polymerase eta, putative 0.0199 0.2502 0.2748
Loa Loa (eye worm) ATP-dependent DNA helicase 0.004 0.0212 0.0242
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0476 0.0658
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.131 0.2173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1017
Loa Loa (eye worm) hypothetical protein 0.0116 0.131 0.1499
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0944 0.1005
Echinococcus multilocularis Protein lozenge 0.0059 0.0478 0.0662
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0161 0.0054
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1106 0.1145
Trypanosoma brucei DNA polymerase eta, putative 0.0199 0.2502 0.2692
Loa Loa (eye worm) pip kinase 2 0.0172 0.2115 0.2419
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0764 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Plasmodium vivax SET domain protein, putative 0.009 0.0935 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0764 0.0803
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.004 0.0212 0.0179
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0172 0.2115 0.2309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0995 0.16
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0588 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Loa Loa (eye worm) runx1 0.0059 0.0478 0.0547
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.1106 0.1265
Trypanosoma brucei unspecified product 0.0119 0.1346 0.139
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.1346 0.1956
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0588 0.0547
Leishmania major DNA polymerase kappa, putative 0.0119 0.1346 0.1499
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.1106 0.1802
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0995 0.16
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0476 0.019
Toxoplasma gondii ABC1 family protein 0.0079 0.0764 0.5403
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0764 0.0486
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.1106 0.1802
Brugia malayi Pip kinase protein 2 0.0172 0.2115 0.2419
Schistosoma mansoni lozenge 0.0059 0.0478 0.0421
Brugia malayi Pre-SET motif family protein 0.009 0.0935 0.107
Leishmania major DNA damage repair protein, putative 0.0037 0.0161 0.018
Mycobacterium ulcerans hypothetical protein 0.0037 0.0161 0.0354
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0502 0.6882 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0476 0.0409
Brugia malayi beta-lactamase family protein 0.0079 0.0764 0.0874
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0476 0.0658
Loa Loa (eye worm) hypothetical protein 0.009 0.0935 0.107
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.004 0.0212 0.0179
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0119 0.1346 0.1086
Loa Loa (eye worm) hypothetical protein 0.0172 0.2115 0.2419
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0212 0.0818
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0557 0.0572
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0557 0.0572
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0476 0.019
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0935 0.0948
Mycobacterium ulcerans hypothetical protein 0.0079 0.0764 0.1676
Echinococcus multilocularis geminin 0.0348 0.4657 0.8248
Onchocerca volvulus 0.0469 0.6404 0.6404
Echinococcus granulosus geminin 0.0348 0.4657 0.8248
Brugia malayi mbt repeat family protein 0.0102 0.1106 0.1265
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.1346 0.2955
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0051 0.0366 0.0458
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0476 0.5
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0172 0.2115 0.3633
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0132 0.0151
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0292 0.0201
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0557 0.0511
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0764 0.111
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0476 0.0545
Schistosoma mansoni DNA polymerase eta 0.0199 0.2502 0.2755
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Schistosoma mansoni blooms syndrome DNA helicase 0.0047 0.0303 0.0218
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.8984 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0944 0.1005
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0588 0.0673
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0935 0.6829
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0557 0.4134
Echinococcus multilocularis dna polymerase kappa 0.0119 0.1346 0.2238
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.004 0.0212 0.2423
Onchocerca volvulus 0.0079 0.0764 0.0764
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0365 0.0417
Entamoeba histolytica hypothetical protein 0.0038 0.0176 0.1304
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0161 0.013
Brugia malayi ThiF family protein 0.0034 0.0113 0.013
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0476 0.8927
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0222 0.0904
Trypanosoma brucei unspecified product 0.0082 0.0813 0.0789
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0212 0.0242
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0161 0.0054
Loa Loa (eye worm) hypothetical protein 0.0178 0.22 0.2517
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.1106 0.1106
Schistosoma mansoni hypothetical protein 0.0634 0.8782 1
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.1346 0.2955
Trichomonas vaginalis set domain proteins, putative 0.0718 1 1
Onchocerca volvulus 0.009 0.0935 0.0935
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.06 0.0317
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0764 0.0486
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0306 0.4056 0.4445
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0172 0.2115 0.3633
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0764 0.0486
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0119 0.1346 0.154
Trypanosoma brucei unspecified product 0.0082 0.0813 0.0789
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0764 0.111
Leishmania major DNA polymerase eta, putative 0.0117 0.1317 0.1466
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.131 0.1499
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.4056 0.4515
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.131 0.2173
Echinococcus granulosus tar DNA binding protein 0.0066 0.0588 0.0861
Trichomonas vaginalis DNA polymerase eta, putative 0.0119 0.1346 0.1086
Brugia malayi beta-lactamase 0.0079 0.0764 0.0874
Loa Loa (eye worm) RNA binding protein 0.0066 0.0588 0.0673
Leishmania major hypothetical protein, conserved 0.0079 0.0764 0.085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0476 0.0482
Toxoplasma gondii exonuclease III APE 0.0059 0.0476 0.3014
Mycobacterium tuberculosis Conserved protein 0.0079 0.0764 0.111
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0557 0.0805
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0935 0.1492
Loa Loa (eye worm) hypothetical protein 0.0469 0.6404 0.7326
Brugia malayi RNA binding protein 0.0066 0.0588 0.0673
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0647 0.8984 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.4056 0.4487
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0476 0.2655
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0935 0.1492
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.131 0.1381
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0161 0.0399
Plasmodium falciparum DNA repair protein REV1, putative 0.0037 0.0161 0.1183
Schistosoma mansoni DNA helicase recq1 0.004 0.0212 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0091 0.0944 0.1005
Brugia malayi mbt repeat family protein 0.0102 0.1106 0.1265
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0166 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0588 0.0547
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0051 0.0366 0.0458
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0476 0.1045
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.1231 0.1327
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.8741 1
Leishmania major DNA polymerase eta, putative 0.0199 0.2502 0.2785
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0365 0.0417
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0476 0.0482
Brugia malayi beta-lactamase family protein 0.0079 0.0764 0.0874
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0588 0.0547
Entamoeba histolytica recQ family helicase, putative 0.0046 0.0292 0.217
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0476 0.4413
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0476 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0161 0.0054
Loa Loa (eye worm) hypothetical protein 0.0199 0.2502 0.2862
Loa Loa (eye worm) MBCTL1 0.0116 0.131 0.1499
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0935 0.0948
Schistosoma mansoni DNA helicase recq5 0.004 0.0212 0.0114
Brugia malayi ThiF family protein 0.0051 0.0366 0.0418
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0185
Brugia malayi polk-prov protein 0.0037 0.0161 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0161 0.0054
Mycobacterium ulcerans beta-lactamase 0.0079 0.0764 0.1676
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0995 0.1138
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0161 0.013
Leishmania major mitochondrial DNA polymerase beta 0.0647 0.8984 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.1346 0.1455
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0172 0.2115 0.2309
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0476 0.0545
Onchocerca volvulus 0.0178 0.22 0.22
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0813 0.0789
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0764 0.0803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0995 0.16
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0764 0.1676
Echinococcus granulosus ATP dependent DNA helicase Q1 0.004 0.0212 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0813 0.0789
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0557 0.0637
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0476 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0212 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0935 0.0948
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0887 0.1405
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0034 0.0113 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0119 0.1346 0.1956
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.131 0.2173
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0415 0.5622 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0588 0.0673
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.1346 0.139
Giardia lamblia DINP protein human, muc B family 0.0119 0.1346 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0166 0.0095
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0588 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Brugia malayi hypothetical protein 0.0178 0.22 0.2517
Loa Loa (eye worm) beta-lactamase 0.0079 0.0764 0.0874
Leishmania major DNA polymerase kappa, putative 0.0037 0.0161 0.018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0341 0.4556 0.662
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.1106 0.1802
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0764 0.0486
Toxoplasma gondii hypothetical protein 0.0104 0.1137 0.8507
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0557 0.062
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0119 0.1346 0.1422
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1106 0.1145
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0176 0.0072
Brugia malayi hypothetical protein 0.0038 0.0176 0.0201
Loa Loa (eye worm) hypothetical protein 0.0047 0.0314 0.0359
Loa Loa (eye worm) RecQ helicase 0.0067 0.06 0.0686
Toxoplasma gondii hypothetical protein 0.0051 0.0366 0.2096
Loa Loa (eye worm) ThiF family protein 0.0034 0.0113 0.013
Echinococcus multilocularis bloom syndrome protein 0.0067 0.06 0.0883
Onchocerca volvulus 0.0079 0.0764 0.0764
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0119 0.1346 0.2238
Entamoeba histolytica deoxycytidyl transferase, putative 0.0119 0.1346 1
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0046 0.0298 0.0213
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0161 0.0054
Echinococcus granulosus bloom syndrome protein 0.0067 0.06 0.0883
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0212 0.0242
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0212 0.0818
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0161 0.0399
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0557 0.05
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0764 0.111
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0292 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0764 0.075
Brugia malayi TAR-binding protein 0.0066 0.0588 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0557 0.0637
Loa Loa (eye worm) hypothetical protein 0.0102 0.1106 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Onchocerca volvulus 0.0102 0.1106 0.1106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0365 0.0417
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0117 0.1317 1
Trypanosoma brucei chrX additional, unordered contigs 0.0037 0.0161 0.0054
Echinococcus granulosus dna polymerase eta 0.0199 0.2502 0.4336
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.06 0.0317
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0764 1
Mycobacterium ulcerans lipase LipD 0.0079 0.0764 0.1676
Giardia lamblia Sgs1 DNA helicase, putative 0.004 0.0212 0.0425
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0764 0.111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0995 0.16
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0119 0.1346 0.2238
Schistosoma mansoni DNA polymerase IV / kappa 0.0037 0.0161 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.1346 0.1455
Onchocerca volvulus 0.0079 0.0764 0.0764
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0764 0.0874
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0764 0.7911
Echinococcus multilocularis dna polymerase eta 0.0199 0.2502 0.4336
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.8984 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0764 0.0874
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0161 0.013
Plasmodium vivax DNA repair protein REV1, putative 0.0037 0.0161 0.0585
Schistosoma mansoni hypothetical protein 0.0035 0.0132 0.0021
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.131 0.2173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0995 0.1138
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0764 0.0874
Brugia malayi hypothetical protein 0.0469 0.6404 0.7326
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0588 0.0673
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0292 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0588 0.0547
Echinococcus granulosus dna polymerase kappa 0.0119 0.1346 0.2238
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.1106 0.1145
Loa Loa (eye worm) hypothetical protein 0.0051 0.0365 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.1346 0.139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0476 0.3536
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0051 0.0366 0.6207
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0062 0.052 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0764 0.111
Mycobacterium leprae Probable lipase LipE 0.0079 0.0764 1
Schistosoma mansoni ap endonuclease 0.0059 0.0476 0.0418
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0764 0.118
Mycobacterium tuberculosis Conserved protein 0.0079 0.0764 0.111
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.0234 0.1462
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0764 0.075
Entamoeba histolytica hypothetical protein 0.0038 0.0176 0.1304
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Mycobacterium ulcerans hypothetical protein 0.0341 0.4556 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0813 0.0789
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.1106 0.1802
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0764 0.0486
Entamoeba histolytica hypothetical protein 0.0038 0.0176 0.1304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1346 0.139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0176 0.0113
Brugia malayi Pre-SET motif family protein 0.0631 0.8741 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0415 0.5622 1
Schistosoma mansoni hypothetical protein 0.0348 0.4657 0.5241
Brugia malayi ImpB/MucB/SamB family protein 0.0199 0.2502 0.2862
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0764 0.111
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0176 0.0113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0935 0.1492
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.1346 0.139
Schistosoma mansoni terminal deoxycytidyl transferase 0.0119 0.1346 0.1422
Onchocerca volvulus 0.0172 0.2115 0.2115
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0119 0.1346 0.1499
Schistosoma mansoni hypothetical protein 0.0348 0.4657 0.5241
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.1346 0.1455
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0764 0.0733
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0091 0.0944 0.0936
Echinococcus granulosus ATP dependent DNA helicase Q5 0.004 0.0212 0.0179

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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