Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | smad | 0.0018 | 0.0092 | 0.0045 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0061 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0464 | 0.0576 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0525 | 0.0744 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0524 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0464 | 0.0879 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0078 | 0.1324 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0203 | 0.3909 | 0.5542 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.018 | 0.3437 | 0.3397 |
Brugia malayi | Thioredoxin reductase | 0.0079 | 0.1346 | 0.2507 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0087 |
Brugia malayi | glutathione reductase | 0.0079 | 0.1346 | 0.2507 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0307 | 0.0435 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0525 | 0.2352 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0078 | 0.1324 | 0.9825 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0464 | 0.0824 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.0443 | 0.2969 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0092 | 0.0045 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0057 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0092 | 0.0175 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0307 | 0.0526 |
Plasmodium vivax | glutathione reductase, putative | 0.0079 | 0.1346 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0245 | 0.4772 | 0.6738 |
Leishmania major | trypanothione reductase | 0.0079 | 0.1346 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0078 | 0.1324 | 0.9825 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | beta-lactamase | 0.0078 | 0.1324 | 0.2464 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0268 | 0.1612 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0443 | 0.2969 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0092 | 0.0116 |
Schistosoma mansoni | lamin | 0.0029 | 0.0307 | 0.0352 |
Brugia malayi | RNA binding protein | 0.0203 | 0.3909 | 0.7394 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0027 | 0.0279 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.0443 | 0.2969 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0078 | 0.1324 | 0.1877 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0092 | 0.0116 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0061 | 0.0086 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0078 | 0.1324 | 0.2464 |
Mycobacterium tuberculosis | Conserved protein | 0.0078 | 0.1324 | 0.127 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0811 | 0.1537 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0524 | 0.0662 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | MH2 domain containing protein | 0.0269 | 0.5275 | 1 |
Echinococcus multilocularis | geminin | 0.0355 | 0.7053 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0092 | 0.0045 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0307 | 0.0582 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.002 | 0.0129 | 0.0186 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0027 | 0.0279 | 0.0396 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0268 | 0.1612 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0203 | 0.3909 | 0.7394 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0036 | 0.046 | 0.0818 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0524 | 0.0742 |
Onchocerca volvulus | 0.0052 | 0.0792 | 0.4769 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0116 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0525 | 0.3609 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0525 | 0.0664 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0027 | 0.0279 | 0.0219 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0092 | 0.0131 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0032 | 0.006 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0525 | 0.0664 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0203 | 0.3909 | 0.7409 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.018 | 0.3437 | 0.3397 |
Mycobacterium ulcerans | lipase LipD | 0.0078 | 0.1324 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0027 | 0.0279 | 0.1696 |
Plasmodium falciparum | thioredoxin reductase | 0.0027 | 0.0279 | 0.1696 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0027 | 0.0279 | 0.1696 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0092 | 0.0116 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0078 | 0.1324 | 0.127 |
Brugia malayi | beta-lactamase family protein | 0.0078 | 0.1324 | 0.2464 |
Brugia malayi | beta-lactamase family protein | 0.0078 | 0.1324 | 0.2464 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0307 | 0.0352 |
Toxoplasma gondii | thioredoxin reductase | 0.0079 | 0.1346 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0115 |
Brugia malayi | Smad1 | 0.0018 | 0.0092 | 0.0116 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.046 | 0.1734 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0092 | 0.0045 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.02 | 0.3853 | 0.3815 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0092 | 0.0131 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.046 | 0.1734 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.3909 | 0.5503 |
Loa Loa (eye worm) | glutathione reductase | 0.0079 | 0.1346 | 0.2551 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0079 | 0.1346 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0092 | 0.0116 |
Loa Loa (eye worm) | RNA binding protein | 0.0203 | 0.3909 | 0.7409 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0027 | 0.0279 | 0.1696 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0078 | 0.1324 | 0.127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0245 | 0.4772 | 0.6738 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0268 | 0.1612 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0027 | 0.0279 | 0.0472 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0078 | 0.1324 | 0.1877 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0525 | 0.3609 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0525 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0525 | 0.3609 |
Trypanosoma brucei | trypanothione reductase | 0.0079 | 0.1346 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0078 | 0.1324 | 0.127 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0792 | 0.1046 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.3909 | 0.5503 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0027 | 0.0279 | 0.0313 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0027 | 0.0279 | 0.1696 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0061 | 0.0086 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0078 | 0.1324 | 0.127 |
Plasmodium falciparum | glutathione reductase | 0.0079 | 0.1346 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Plasmodium falciparum | glutathione reductase | 0.0027 | 0.0279 | 0.1696 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0027 | 0.0279 | 0.1696 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0307 | 0.0435 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0307 | 0.0435 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0525 | 0.0744 |
Echinococcus multilocularis | smad | 0.0018 | 0.0092 | 0.0131 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.002 | 0.0129 | 0.0186 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0525 | 0.2352 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0078 | 0.1324 | 0.2509 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0268 | 0.0509 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0087 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.0525 | 0.2352 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0092 | 0.0131 |
Leishmania major | hypothetical protein, conserved | 0.0078 | 0.1324 | 0.9825 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0078 | 0.1324 | 0.1806 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0027 | 0.0279 | 0.0396 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Loa Loa (eye worm) | beta-lactamase | 0.0078 | 0.1324 | 0.2509 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0524 | 0.0938 |
Echinococcus granulosus | geminin | 0.0355 | 0.7053 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.008 | 0.1368 | 0.1939 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0061 | 0.0086 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0524 | 0.9835 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.046 | 0.0873 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.02 | 0.3853 | 0.3815 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0524 | 0.9835 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0245 | 0.4772 | 0.6767 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0245 | 0.4772 | 0.9046 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0245 | 0.4772 | 0.9041 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0256 | 0.5001 | 0.709 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0078 | 0.1324 | 0.9825 |
Echinococcus granulosus | tar DNA binding protein | 0.0203 | 0.3909 | 0.5542 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.7053 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0078 | 0.1324 | 0.127 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0092 | 0.0131 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0269 | 0.5275 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0079 | 0.1346 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0525 | 0.3609 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.018 | 0.3437 | 0.3397 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0092 | 0.0045 |
Plasmodium vivax | hypothetical protein, conserved | 0.0078 | 0.1324 | 0.9825 |
Echinococcus granulosus | lamin | 0.0029 | 0.0307 | 0.0435 |
Mycobacterium tuberculosis | Probable reductase | 0.018 | 0.3437 | 0.3397 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.0443 | 0.2969 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0061 | 0.0087 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0245 | 0.4772 | 0.6738 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0027 | 0.0279 | 0.1696 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.3909 | 0.5503 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0524 | 0.0662 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0079 | 0.1346 | 1 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0092 | 0.0131 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0078 | 0.1324 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0078 | 0.1324 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0268 | 0.0452 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0092 | 0.0175 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.018 | 0.3437 | 0.3397 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0061 | 0.0086 |
Mycobacterium tuberculosis | Conserved protein | 0.0078 | 0.1324 | 0.127 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0078 | 0.1324 | 1 |
Onchocerca volvulus | 0.0078 | 0.1324 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.5001 | 0.9479 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.046 | 0.0653 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0087 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0268 | 0.1612 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0078 | 0.1324 | 0.1806 |
Echinococcus granulosus | smad | 0.0018 | 0.0092 | 0.0131 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0792 | 0.145 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0245 | 0.4772 | 0.6767 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0524 | 0.9835 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0269 | 0.5275 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0072 | 0.0077 |
Brugia malayi | hypothetical protein | 0.0256 | 0.5001 | 0.9476 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0268 | 0.1612 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0092 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1324 | 0.2509 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.3909 | 0.5503 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.3909 | 0.5503 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0307 | 0.0582 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0524 | 0.9835 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0268 | 0.1612 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0078 | 0.1324 | 0.127 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0061 | 0.0056 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0811 | 0.1486 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.046 | 0.0653 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0092 | 0.0045 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0087 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.018 | 0.3437 | 0.8357 |
Brugia malayi | TAR-binding protein | 0.0203 | 0.3909 | 0.7394 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0296 | 0.0562 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0078 | 0.1324 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0078 | 0.1324 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0078 | 0.1324 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.018 | 0.3437 | 0.3397 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0078 | 0.1324 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0078 | 0.1324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0811 | 0.1537 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0307 | 0.0435 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0268 | 0.1612 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0027 | 0.0279 | 0.1696 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.7053 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0525 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.008 | 0.1368 | 0.1939 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0268 | 0.1612 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0525 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0203 | 0.3909 | 0.7409 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0027 | 0.0279 | 0.1696 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.0525 | 0.0466 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0307 | 0.0526 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.02 | 0.3853 | 0.3815 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0525 | 0.0995 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0061 | 0.0056 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0443 | 0.2969 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.0525 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0811 | 0.1486 |
Schistosoma mansoni | lamin | 0.0029 | 0.0307 | 0.0352 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0525 | 0.0941 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0525 | 0.3609 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0061 | 0.0086 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0078 | 0.1324 | 0.127 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0092 | 0.0175 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0079 | 0.1346 | 0.1293 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0525 | 0.3609 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0061 | 0.0086 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0027 | 0.0279 | 0.1696 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.02 | 0.3853 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0027 | 0.0279 | 0.1696 |
Schistosoma mansoni | rotamase | 0.0036 | 0.046 | 0.0571 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0256 | 0.5001 | 0.709 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0525 | 0.3609 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0307 | 0.0435 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0079 | 0.1346 | 0.2551 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0443 | 0.1565 |
Onchocerca volvulus | 0.0078 | 0.1324 | 1 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0078 | 0.1324 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0078 | 0.1324 | 0.9825 |
Onchocerca volvulus | 0.0078 | 0.1324 | 1 | |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0792 | 0.1046 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0061 | 0.0087 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0245 | 0.4772 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0307 | 0.0582 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0245 | 0.4772 | 0.6767 |
Mycobacterium ulcerans | beta-lactamase | 0.0078 | 0.1324 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 79.33 % | Cytotoxicity against human NSCLC cells assessed as cell growth at 100 uM after 48 hrs by SRB assay | ChEMBL. | 21122952 |
GI50 (functional) | -4.751 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.744 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.652 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.636 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.616 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.61 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.566 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.528 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.438 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.143 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of human recombinant NQO1 at 100 uM | ChEMBL. | 21074425 | |
Inhibition (binding) | Inhibition of human recombinant NQO2 at 100 uM | ChEMBL. | 21074425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.