Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.207 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4105 | 0.4105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4105 | 1 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4105 | 0.4105 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.207 | 0.207 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.207 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4105 | 0.4105 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4105 | 0.4105 |
Brugia malayi | hypothetical protein | 0.0037 | 0.207 | 0.207 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4105 | 0.4105 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.207 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.207 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.8271 | 0.8271 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.8271 | 0.8271 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4105 | 0.4105 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.9189 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.3772 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4105 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.3772 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.9189 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.207 | 0.5043 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.3772 | 0.3772 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.207 | 0.207 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.8271 | 0.8271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4105 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4105 | 0.4105 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.207 | 0.5043 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.3772 | 0.3772 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4105 | 0.4105 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4105 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.3772 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding | ChEMBL. | 20860381 | |
Emax (functional) | Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding relative to serotonin | ChEMBL. | 20860381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.