TDR Targets

Basic information

Technical information

TDR Targets ID: 1262495
Name: 1-(4-fluorophenyl)-4-(3-phenylbutyl)piperazin e
MW: 312.424 | Formula: C20H25FN2
H donors: 0 H acceptors: 0 LogP: 4.6 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)N1CCN(CC1)CCC(c1ccccc1)C
InChi: 1S/C20H25FN2/c1-17(18-5-3-2-4-6-18)11-12-22-13-15-23(16-14-22)20-9-7-19(21)8-10-20/h2-10,17H,11-16H2,1H3
InChiKey: GPNQMDLKARMLTR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_563146
MLS000974619
SMR000496390

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0124	0.024
Loa Loa (eye worm)	DR-78	0.0015	0.0124	0.024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0796	0.0793
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0508	0.1005
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0218	0.0427
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0796	0.068
Brugia malayi	ecdysone receptor	0.0015	0.0124	0.0245
Echinococcus granulosus	tar DNA binding protein	0.013	0.2756	0.2754
Brugia malayi	manba-prov protein	0.0078	0.1574	0.3115
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0165	0.0321
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0508	1
Brugia malayi	Beta-glucuronidase precursor	0.0223	0.4903	0.9704
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0124	0.0121
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0508	0.0505
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0124	0.0245
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.097	1
Echinococcus multilocularis	cpg binding protein	0.0033	0.0539	0.0537
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0218	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Brugia malayi	TAR-binding protein	0.013	0.2756	0.5455
Onchocerca volvulus		0.0031	0.0498	0.9749
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0508	0.1005
Schistosoma mansoni	tar DNA-binding protein	0.013	0.2756	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0508	0.0389
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0218	0.0432
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0796	0.1575
Onchocerca volvulus		0.0032	0.0508	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0251	0.5
Brugia malayi	hypothetical protein	0.0015	0.0124	0.0245
Echinococcus granulosus	cpg binding protein	0.0033	0.0539	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Schistosoma mansoni	hypothetical protein	0.0445	1	1
Schistosoma mansoni	tar DNA-binding protein	0.013	0.2756	0.2665
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.023	0.5052	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0726	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0508	0.0505
Brugia malayi	nuclear receptor RXR	0.0017	0.0165	0.0327
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0124	0.024
Brugia malayi	RNA recognition motif domain containing protein	0.013	0.2756	0.5455
Schistosoma mansoni	hypothetical protein	0.0023	0.0314	0.0193
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0124	0.0245
Schistosoma mansoni	tar DNA-binding protein	0.013	0.2756	0.2665
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0508	0.0505
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0124	0.0245
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0251	0.0491
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0124	0.0245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0796	0.068
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0251	0.0496
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0508	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0508	0.1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0165	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0508	0.1005
Schistosoma mansoni	hypothetical protein	0.0019	0.0218	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0251	0.5
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0314	0.0311
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0124	0.0245
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0508	0.1005
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0165	0.0042
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0508	0.0389
Brugia malayi	hypothetical protein	0.0033	0.0548	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0165	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0796	0.157
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0508	0.1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0508	0.1005
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0218	0.0216
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.097	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0508	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.097	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0251	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0508	0.0389
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0508	0.1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Entamoeba histolytica	beta-galactosidase, putative	0.0163	0.3516	1
Trichomonas vaginalis	conserved hypothetical protein	0.0241	0.5309	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0796	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0052	0.097	0.1915
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0508	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0508	0.0505
Brugia malayi	hypothetical protein	0.0052	0.097	0.192
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0508	0.0505
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0508	0.0505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0508	0.1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0508	0.0505
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0251	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0124	0.0121
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0124	0.0121
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0796	0.0793
Brugia malayi	hypothetical protein	0.0015	0.0124	0.0245
Schistosoma mansoni	hypothetical protein	0.0019	0.0218	0.0096
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0218	0.0216
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0508	0.0389
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1163	0.2303
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0508	0.0505
Loa Loa (eye worm)	beta-glucuronidase	0.0223	0.4903	0.9704
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0508	0.1005
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0508	0.0389
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0508	0.0389
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0251	0.0248
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1303	0.1194
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0508	0.0505
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0508	0.1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0508	0.1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0508	0.0389
Schistosoma mansoni	cpg binding protein	0.0033	0.0539	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0508	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	RNA binding protein	0.013	0.2756	0.5452
Trichomonas vaginalis	glycoside hydrolase, putative	0.0241	0.5309	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.097	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.097	1
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0218	0.0432
Brugia malayi	nuclear hormone receptor	0.0015	0.0124	0.0245
Brugia malayi	RNA binding protein	0.013	0.2756	0.5455
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1163	0.2298
Brugia malayi	ecdysteroid receptor	0.0032	0.0508	0.1005
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0508	0.1005
Trichomonas vaginalis	beta-galactosidase, putative	0.0241	0.5309	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0508	0.1005
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0165	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0165	0.0321
Schistosoma mansoni	hypothetical protein	0.0019	0.0218	0.0096
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0508	0.0505
Brugia malayi	hypothetical protein	0.0017	0.0165	0.0327
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0508	0.0505
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0508	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0726	0.1432
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.013	0.2756	0.5452
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0165	0.0327
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0165	0.0162
Schistosoma mansoni	hypothetical protein	0.0019	0.0218	0.0096
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0165	0.0042
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.097	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0124	0.0121
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0124	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0796	0.068
Schistosoma mansoni	hypothetical protein	0.0041	0.0726	0.061
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0124	0.0245
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.023	0.5052	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0508	0.1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0508	0.0505
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0124	0.0121
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0251	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0124	0.0121
Schistosoma mansoni	ap endonuclease	0.002	0.0251	0.0128
Loa Loa (eye worm)	TAR-binding protein	0.013	0.2756	0.5452
Schistosoma mansoni	beta-mannosidase	0.0078	0.1574	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0145	0.311	0.6154
Brugia malayi	nuclear hormone receptor	0.0032	0.0508	0.1005
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0218	0.0216
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0124	0.0121
Schistosoma mansoni	coup transcription factor	0.0032	0.0508	0.0389
Brugia malayi	conserved hypotetical protein	0.0015	0.0124	0.0245
Schistosoma mansoni	hypothetical protein	0.0085	0.1723	0.1619
Schistosoma mansoni	tar DNA-binding protein	0.013	0.2756	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0218	0.0427
Loa Loa (eye worm)	hypothetical protein	0.006	0.1163	0.2298
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0124	0.0245
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0251	0.0248
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0218	0.0216
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0165	0.0321
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0508	0.1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0508	0.0505
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0508	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Echinococcus multilocularis	tar DNA binding protein	0.013	0.2756	0.2754
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0124	0.0121
Echinococcus granulosus	GPCR family 2	0.0019	0.0218	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0508	0.1005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1163	0.2303
Leishmania major	hypothetical protein, conserved	0.0052	0.097	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0015	0.0124	0.0121
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0508	0.0389
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0508	0.0389
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.097	0.8084
Schistosoma mansoni	tar DNA-binding protein	0.013	0.2756	0.2665
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0508	0.0389
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0508	0.1005
Echinococcus multilocularis	dnaJ subfamily B	0.0445	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0124	0.0245
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0508	0.1005
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0314	0.0311
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0508	0.0389
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0508	0.1005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0508	0.1005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0796	0.0793
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0124	0.0121
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.114	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0165	0.0321
Brugia malayi	steroid hormone receptor	0.0032	0.0508	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.024
Trichomonas vaginalis	beta-mannosidase, putative	0.0078	0.1574	0.2616
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0508	0.1
Brugia malayi	hypothetical protein	0.0017	0.0165	0.0327
Brugia malayi	nuclear receptor RXR	0.0015	0.0124	0.0245
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0508	0.0505
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0508	0.0505
Schistosoma mansoni	cpg binding protein	0.0033	0.0539	0.0421
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0508	0.0505
Brugia malayi	tailless protein	0.0015	0.0124	0.0245
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0508	0.0505
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0498	0.0986
Schistosoma mansoni	cpg binding protein	0.0031	0.0498	0.0379
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0498	0.0981
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0508	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0165	0.0321
Schistosoma mansoni	ap endonuclease	0.002	0.0251	0.0128
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0124	0.0121
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0508	0.0389

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1363216

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1262495