Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3202 | 0.4745 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0328 | 0.0485 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.6748 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0024 | 0.0307 | 0.0307 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2545 | 0.3771 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3853 | 0.571 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0623 | 0.0924 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.003 | 0.0623 | 0.0924 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.6748 | 0.6748 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1272 | 0.1885 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.003 | 0.0623 | 0.0924 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1126 | 0.1669 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0214 | 0.0214 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.6748 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.6748 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0088 | 0.3853 | 0.3853 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.6748 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.3457 | 0.4759 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0214 | 0.0317 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.2758 | 0.2758 |
Brugia malayi | hypothetical protein | 0.0088 | 0.3853 | 0.5389 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1268 | 0.1272 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.6748 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.6748 | 0.6748 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1527 | 0.2263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.6748 | 0.6748 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0151 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1413 | 0.2094 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1126 | 0.1669 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.0623 | 0.0246 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0037 | 0.0054 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0328 | 0.0328 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0328 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3853 | 0.571 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0151 | 0.0223 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2545 | 0.3771 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.6748 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.0307 | 0.0455 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting | ChEMBL. | 21055954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.