Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4949 | 0.8845 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1767 | 0.1767 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.2467 | 0.2714 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3289 | 0.3289 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1767 | 0.3157 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4949 | 0.8845 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4949 | 0.8845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4949 | 0.8845 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2467 | 0.2467 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4949 | 0.4949 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4949 | 0.4949 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4949 | 0.4949 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4949 | 0.8845 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.277 | 0.3419 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.277 | 0.3419 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4949 | 0.4949 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.2467 | 0.2467 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4949 | 0.8845 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.5595 | 1 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.5595 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.5595 | 0.5595 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.5595 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.5595 | 0.5595 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4949 | 0.8845 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.2467 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1605 | 0.1605 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.5595 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.5595 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.2467 | 0.7399 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.5595 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3289 | 0.3289 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.5595 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.5595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4949 | 0.4949 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.277 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4949 | 0.4949 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by twofold serial dilution method | ChEMBL. | 20833454 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli 08-21 after 18 to 24 hrs by twofold serial dilution method | ChEMBL. | 20833454 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli 08-22 after 18 to 24 hrs by twofold serial dilution method | ChEMBL. | 20833454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.