Detailed information for compound 1263237

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.317 | Formula: C19H15BrN4O2S
  • H donors: 0 H acceptors: 4 LogP: 3.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nnc2c(n1)O[C@@H](c1ccc(cc1)Br)N(c1c2cccc1)C(=O)C
  • InChi: 1S/C19H15BrN4O2S/c1-11(25)24-15-6-4-3-5-14(15)16-17(21-19(27-2)23-22-16)26-18(24)12-7-9-13(20)10-8-12/h3-10,18H,1-2H3/t18-/m0/s1
  • InChiKey: SBISWPGQJKKIPF-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1021 0.1019
Echinococcus multilocularis musashi 0.0083 0.0716 0.0932
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1389 0.4144
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1389 1
Brugia malayi intermediate filament protein 0.0083 0.0716 0.1077
Entamoeba histolytica hypothetical protein 0.0145 0.1409 1
Mycobacterium tuberculosis Conserved protein 0.0143 0.1389 0.1387
Mycobacterium ulcerans glutaminase 0.0295 0.3075 1
Leishmania major cathepsin L-like protease 0.0065 0.0513 0.3334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0292 0.0439
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0112
Schistosoma mansoni inositol monophosphatase 0.0036 0.0195 0.0258
Echinococcus granulosus GPCR family 2 0.0031 0.0141 0.0183
Plasmodium vivax glutathione reductase, putative 0.0048 0.033 0.2363
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0247 0.0322
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0462 0.0601
Plasmodium falciparum thioredoxin reductase 0.0048 0.033 0.8958
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.045 0.2133
Trichomonas vaginalis esterase, putative 0.0143 0.1389 0.4144
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.7568 1
Echinococcus multilocularis lamin 0.0083 0.0716 0.0932
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0145 0.1409 0.1862
Mycobacterium ulcerans lipase LipD 0.0143 0.1389 0.4512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Echinococcus granulosus tar DNA binding protein 0.0324 0.3406 0.4432
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.033 0.0328
Entamoeba histolytica hypothetical protein 0.0145 0.1409 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0716 0.1077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0143 0.1389 0.1387
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0368 0.1449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0074 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0292 0.038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0143 0.1389 0.1387
Mycobacterium tuberculosis Probable lipase LipD 0.0143 0.1389 0.1387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Brugia malayi RNA recognition motif domain containing protein 0.0324 0.3406 0.512
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1158 0.8246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0141 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0368 0.2638
Echinococcus granulosus lamin 0.0083 0.0716 0.0932
Trypanosoma brucei trypanothione reductase 0.0048 0.033 0.113
Brugia malayi hypothetical protein 0.0145 0.1409 0.2118
Schistosoma mansoni intermediate filament proteins 0.0083 0.0716 0.0947
Mycobacterium leprae conserved hypothetical protein 0.0143 0.1389 1
Trichomonas vaginalis glutaminase, putative 0.0295 0.3075 1
Mycobacterium ulcerans beta-lactamase 0.0143 0.1389 0.4512
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0716 0.1077
Leishmania major hypothetical protein, conserved 0.0052 0.0368 0.2237
Loa Loa (eye worm) glutaminase 0.0295 0.3075 0.4624
Echinococcus multilocularis GPCR, family 2 0.0031 0.0141 0.0183
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0212
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0259 0.0336
Brugia malayi Smad1 0.0042 0.0259 0.0389
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Onchocerca volvulus 0.0104 0.0946 0.6814
Schistosoma mansoni lamin 0.0083 0.0716 0.0947
Loa Loa (eye worm) hypothetical protein 0.0104 0.0946 0.1423
Echinococcus granulosus smad 0.0042 0.0259 0.0336
Echinococcus multilocularis Smad4 0.0042 0.0259 0.0336
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1304 0.1723
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.1409 0.1833
Loa Loa (eye worm) hypothetical protein 0.0052 0.0368 0.0554
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0195 0.0254
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.033 0.2363
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0287 0.0431
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0358 0.1364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0897 0.1348
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0336 0.0505
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.7568 0.9848
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0074 0.0112
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0143 0.1389 0.1387
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0238 0.0309
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0247 0.0322
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0195 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0074 0.0233
Loa Loa (eye worm) glutathione reductase 0.0048 0.033 0.0497
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0513 0.2658
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0153 0.015
Loa Loa (eye worm) nuclear factor I 0.0023 0.005 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0292 0.038
Schistosoma mansoni hypothetical protein 0.0126 0.1191 0.1574
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0462 0.0601
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2492 0.3242
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0195 0.0921
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0057 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0368 0.1449
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1389 0.4144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0897 0.1348
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1021 0.1019
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.041 0.0542
Toxoplasma gondii thioredoxin reductase 0.0048 0.033 0.113
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0716 0.1077
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0946 0.1251
Brugia malayi RNA binding protein 0.0324 0.3406 0.512
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0143 0.1389 0.4512
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.033 0.043
Schistosoma mansoni Smad4 0.0042 0.0259 0.0342
Echinococcus granulosus Smad4 0.0042 0.0259 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0141 0.0183
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0259 0.0389
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0324 0.3406 0.512
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0287 0.0431
Echinococcus multilocularis smad 0.0042 0.0259 0.0336
Brugia malayi MH2 domain containing protein 0.0042 0.0259 0.0389
Leishmania major cathepsin L-like protease 0.0065 0.0513 0.3334
Loa Loa (eye worm) glutaminase 2 0.0295 0.3075 0.4624
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0292 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3406 0.45
Schistosoma mansoni survival motor neuron protein 0.0049 0.0342 0.0452
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0074 0.0233
Schistosoma mansoni glutaminase 0.0295 0.3075 0.4064
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1021 0.1019
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.1389 1
Echinococcus granulosus tumor protein p63 0.0709 0.7685 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1191 0.155
Schistosoma mansoni smad1 5 8 and 0.0042 0.0259 0.0342
Schistosoma mansoni hypothetical protein 0.0068 0.0547 0.0723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0259 0.0336
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0259 0.0389
Schistosoma mansoni hypothetical protein 0.0049 0.0342 0.0452
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1191 0.155
Echinococcus granulosus intermediate filament protein 0.0083 0.0716 0.0932
Echinococcus granulosus microtubule associated protein 2 0.0698 0.7568 0.9848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0292 0.0386
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.1304 0.1696
Echinococcus multilocularis lamin dm0 0.0083 0.0716 0.0932
Onchocerca volvulus 0.0083 0.0716 0.5157
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1389 0.4144
Onchocerca volvulus 0.0143 0.1389 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0141 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3406 0.45
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3406 0.45
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1021 0.7202
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.1389 0.4144
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0074 0.0112
Mycobacterium tuberculosis Probable hydrolase 0.0143 0.1389 0.1387
Mycobacterium tuberculosis Probable lipase LipE 0.0143 0.1389 0.1387
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0513 0.2658
Loa Loa (eye worm) hypothetical protein 0.0242 0.2492 0.3746
Mycobacterium tuberculosis Probable esterase LipL 0.0143 0.1389 0.1387
Brugia malayi MH1 domain containing protein 0.0023 0.005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0699 0.1052
Brugia malayi MH1 domain containing protein 0.0042 0.0259 0.0389
Onchocerca volvulus 0.0143 0.1389 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1158 0.1156
Onchocerca volvulus 0.0049 0.0342 0.2462
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0112
Plasmodium falciparum glutathione reductase 0.0048 0.033 0.8958
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1158 0.1156
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0141 0.0183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0112
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0259 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Mycobacterium leprae Probable lipase LipE 0.0143 0.1389 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0897 0.1348
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3406 0.45
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0513 0.2658
Loa Loa (eye worm) MH2 domain-containing protein 0.0616 0.6652 1
Leishmania major trypanothione reductase 0.0048 0.033 0.1947
Loa Loa (eye worm) beta-lactamase 0.0143 0.1389 0.2088
Brugia malayi glutaminase DH11.1 0.0295 0.3075 0.4624
Schistosoma mansoni hypothetical protein 0.0171 0.1691 0.2234
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0353 0.053
Echinococcus granulosus beta LACTamase domain containing family member 0.0143 0.1389 0.1807
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.033 0.113
Mycobacterium tuberculosis Conserved protein 0.0143 0.1389 0.1387
Brugia malayi beta-lactamase family protein 0.0143 0.1389 0.2088
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0259 0.0336
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.005 0.0065
Brugia malayi hypothetical protein 0.0052 0.0368 0.0554
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1158 0.1156
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0195 0.0907
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0074 0.0233
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0153 0.0598
Onchocerca volvulus 0.0025 0.0074 0.0536
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0342 0.0514
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0143 0.1389 0.2088
Brugia malayi Cytochrome P450 family protein 0.005 0.0353 0.053
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0074 0.0233
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0332
Echinococcus granulosus geminin 0.0171 0.1691 0.22
Loa Loa (eye worm) RNA binding protein 0.0324 0.3406 0.512
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0195 0.0627
Loa Loa (eye worm) transcription factor SMAD2 0.0616 0.6652 1
Leishmania major hypothetical protein, conserved 0.0143 0.1389 1
Schistosoma mansoni smad1 5 8 and 0.0042 0.0259 0.0342
Brugia malayi hypothetical protein 0.0242 0.2492 0.3746
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1021 0.1019
Mycobacterium ulcerans esterase/lipase LipP 0.0143 0.1389 0.4512
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0186
Schistosoma mansoni smad1 5 8 and 0.0042 0.0259 0.0342
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0141 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Brugia malayi MH2 domain containing protein 0.0616 0.6652 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0462 0.0694
Schistosoma mansoni inositol monophosphatase 0.0036 0.0195 0.0258
Schistosoma mansoni hypothetical protein 0.0023 0.005 0.0066
Mycobacterium ulcerans hypothetical protein 0.0025 0.0074 0.0233
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0186
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.1409 0.1862
Mycobacterium tuberculosis Conserved protein 0.0143 0.1389 0.1387
Leishmania major cathepsin L-like protease 0.0065 0.0513 0.3334
Schistosoma mansoni smad 0.0042 0.0259 0.0342
Entamoeba histolytica hypothetical protein 0.0145 0.1409 1
Schistosoma mansoni lamin 0.0083 0.0716 0.0947
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0141 0.0212
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0238 0.0309
Brugia malayi Inositol-1 0.0036 0.0195 0.0294
Loa Loa (eye worm) hypothetical protein 0.0099 0.0897 0.1348
Loa Loa (eye worm) Smad1 0.0042 0.0259 0.0389
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0716 0.1077
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.1389 0.4144
Loa Loa (eye worm) TAR-binding protein 0.0324 0.3406 0.512
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0368 0.1449
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0547 0.0822
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0143 0.1389 0.2088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Echinococcus multilocularis geminin 0.0171 0.1691 0.22
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0357
Loa Loa (eye worm) glutamate receptor 0.0019 0.0005 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.033 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0292 0.0386
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0822
Brugia malayi TAR-binding protein 0.0324 0.3406 0.512
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.033 0.0497
Brugia malayi beta-lactamase family protein 0.0143 0.1389 0.2088
Brugia malayi beta-lactamase 0.0143 0.1389 0.2088
Onchocerca volvulus 0.0143 0.1389 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0074 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1389 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.1389 0.1835
Plasmodium vivax hypothetical protein, conserved 0.0143 0.1389 1
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1304 0.1723
Schistosoma mansoni hypothetical protein 0.0171 0.1691 0.2234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0074 0.0233
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0186
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0247 0.0327
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0368 1
Toxoplasma gondii ABC1 family protein 0.0143 0.1389 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0259 0.0342
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2492 0.3242
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0003 0.5
Brugia malayi glutathione reductase 0.0048 0.033 0.0497
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0513 0.2658
Entamoeba histolytica hypothetical protein 0.0145 0.1409 1
Mycobacterium tuberculosis Probable reductase 0.011 0.1021 0.1019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0292 0.0386
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0074 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Loa Loa (eye worm) hypothetical protein 0.0143 0.1389 0.2088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0292 0.038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.1389 0.1835
Brugia malayi hypothetical protein 0.0033 0.0164 0.0246
Loa Loa (eye worm) glutamate receptor 0.0049 0.0336 0.0505
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0195 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0368 0.1449
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3406 0.45
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1021 0.1019
Echinococcus multilocularis tumor protein p63 0.0709 0.7685 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0074 0.0233
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0141 0.0183
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0332
Echinococcus granulosus lamin dm0 0.0083 0.0716 0.0932
Mycobacterium ulcerans hypothetical protein 0.0143 0.1389 0.4512
Brugia malayi MH1 domain containing protein 0.0042 0.0259 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Brugia malayi MH2 domain containing protein 0.0042 0.0259 0.0389
Brugia malayi Thioredoxin reductase 0.0048 0.033 0.0497
Echinococcus multilocularis beta LACTamase domain containing family member 0.0143 0.1389 0.1807
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0368 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.1409 0.1833
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0057 0.0085
Brugia malayi MH1 domain containing protein 0.0023 0.005 0.0075
Echinococcus multilocularis tar DNA binding protein 0.0324 0.3406 0.4432
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0285 0.0428
Onchocerca volvulus 0.0083 0.0716 0.5157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0292 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0513 0.2658
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Loa Loa (eye worm) inositol-1 0.0036 0.0195 0.0294

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.82 Inhibition of rat mGluR1 expressed in HEK293 cells ChEMBL. 20732812

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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