TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 489.456 | Formula: C17H17F6N3O3S2
H donors: 1 H acceptors: 4 LogP: 3.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)c1ccc(cc1)N1CCN(CC1)c1ncc(s1)C(C(F)(F)F)(C(F)(F)F)O
InChi: 1S/C17H17F6N3O3S2/c1-31(28,29)12-4-2-11(3-5-12)25-6-8-26(9-7-25)14-24-10-13(30-14)15(27,16(18,19)20)17(21,22)23/h2-5,10,27H,6-9H2,1H3
InChiKey: RQTMJKBJDFCKEP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	malonyl-CoA decarboxylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania donovani	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania infantum	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma congolense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania major	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei gambiense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Brugia malayi	putative malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania braziliensis	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania mexicana	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0207	0.0365
Entamoeba histolytica	hypothetical protein	0.004	0.0642	0.2492
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Schistosoma mansoni	apoferritin-2	0.0009	0.0026	0.0078
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0804	0.2446
Schistosoma mansoni	ferritin	0.0009	0.0026	0.0078
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.1173	0.3571
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0641	0.195
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.001	0.0031
Brugia malayi	PHD-finger family protein	0.0028	0.0394	0.0394
Schistosoma mansoni	apoferritin-2	0.0009	0.0026	0.0078
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0642	0.1271
Brugia malayi	beta-lactamase family protein	0.004	0.0642	0.0642
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0642	1
Echinococcus multilocularis	zinc finger protein	0.0022	0.0274	0.0835
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0642	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0642	0.0642
Loa Loa (eye worm)	beta-lactamase	0.004	0.0642	0.0642
Brugia malayi	N-terminal motif family protein	0.0176	0.3379	0.3379
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0642	0.1955
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0642	0.0642
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.001	0.001
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0298	0.0298
Schistosoma mansoni	ap endonuclease	0.0018	0.0207	0.063
Schistosoma mansoni	ferritin light chain	0.0009	0.0026	0.0078
Onchocerca volvulus		0.0029	0.0422	0.092
Toxoplasma gondii	ABC1 family protein	0.004	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Mycobacterium ulcerans	beta-lactamase	0.004	0.0642	1
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Schistosoma mansoni	hypothetical protein	0.0023	0.0298	0.0907
Brugia malayi	Bromodomain containing protein	0.0043	0.0694	0.0694
Trichomonas vaginalis	esterase, putative	0.004	0.0642	0.1383
Mycobacterium ulcerans	lipase LipD	0.004	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2241	0.2241
Onchocerca volvulus		0.004	0.0642	0.1413
Mycobacterium leprae	Probable lipase LipE	0.004	0.0642	1
Brugia malayi	DIX domain containing protein	0.0009	0.001	0.001
Echinococcus multilocularis	geminin	0.0171	0.3286	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.001
Schistosoma mansoni	zinc finger protein	0.0017	0.0178	0.0543
Schistosoma mansoni	ferritin	0.0009	0.0026	0.0078
Brugia malayi	serine/threonine-protein kinase plk-2	0.0105	0.1952	0.1952
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0642	0.1383
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.001	0.001
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0727	0.0727
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Schistosoma mansoni	hypothetical protein	0.0171	0.3286	1
Echinococcus granulosus	expressed protein	0.0009	0.0026	0.0078
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0341	0.1037
Mycobacterium tuberculosis	Conserved protein	0.004	0.0642	0.1242
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.1173	0.3571
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0422	0.1283
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0804	0.2446
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2247	0.2247
Schistosoma mansoni	dishevelled	0.0009	0.001	0.0031
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.004	0.0642	0.2492
Onchocerca volvulus	Huntingtin homolog	0.0119	0.2241	0.4984
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.001
Trypanosoma cruzi	polo-like protein kinase, putative	0.0105	0.1952	0.4858
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0207	0.5
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0642	0.1242
Brugia malayi	Pre-SET motif family protein	0.0029	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0791	0.0791
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.001	0.0031
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.001	0.0031
Brugia malayi	hypothetical protein	0.0119	0.2241	0.2241
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0207	0.0182
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0727	0.0727
Brugia malayi	beta-lactamase	0.004	0.0642	0.0642
Schistosoma mansoni	hypothetical protein	0.0171	0.3286	1
Mycobacterium tuberculosis	Conserved protein	0.004	0.0642	0.1242
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0105	0.1952	0.5942
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.001	0.0031
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0804	0.2446
Echinococcus multilocularis	expressed protein	0.0009	0.0026	0.0078
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0642	0.1955
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0727	0.2212
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0727	0.2212
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0207	0.0078
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0218	0.0663
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.04	0.1218
Schistosoma mansoni	ferritin	0.0009	0.0026	0.0078
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0642	0.1383
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3829	1
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.001	0.0031
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0642	0.1383
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0422	0.6509
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.3921	0.3921
Schistosoma mansoni	zinc finger protein	0.0022	0.0274	0.0835
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0804	0.2446
Echinococcus granulosus	geminin	0.0171	0.3286	1
Brugia malayi	beta-lactamase family protein	0.004	0.0642	0.0642
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.001	0.0031
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0642	0.1242
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0207	1
Schistosoma mansoni	dep domain containing protein	0.0009	0.001	0.0031
Brugia malayi	MH2 domain containing protein	0.012	0.2247	0.2247
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0105	0.1952	0.4858
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0642	0.1242
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.001	0.0031
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0642	0.1242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0727	0.2212
Trypanosoma cruzi	polo-like protein kinase, putative	0.0105	0.1952	0.4858
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2247	0.2247
Schistosoma mansoni	hypothetical protein	0.0017	0.0178	0.0543
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.001	0.0031
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3829	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0207	0.0406
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0642	0.1955
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0207	0.0207
Schistosoma mansoni	ferritin light chain	0.0009	0.0026	0.0078
Onchocerca volvulus		0.004	0.0642	0.1413
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0207	0.2938
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0642	0.1242
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0218	0.0663
Plasmodium vivax	SET domain protein, putative	0.0029	0.0422	0.4932
Onchocerca volvulus	Huntingtin homolog	0.0119	0.2241	0.4984
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0642	1
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.001	0.0031
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0883	0.1923
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0748	0.0748
Schistosoma mansoni	hypothetical protein	0.004	0.0642	0.1953
Leishmania major	malonyl-coa decarboxylase-like protein	0.0198	0.3829	1
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0642	0.1271
Mycobacterium tuberculosis	Conserved protein	0.004	0.0642	0.1242
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.001	0.0031
Brugia malayi	Bromodomain containing protein	0.0083	0.1516	0.1516
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0642	0.1242
Schistosoma mansoni	bromodomain containing protein	0.007	0.1254	0.3815
Brugia malayi	Pre-SET motif family protein	0.0203	0.3921	0.3921
Schistosoma mansoni	ferritin	0.0009	0.0026	0.0078
Mycobacterium ulcerans	hypothetical protein	0.004	0.0642	1
Toxoplasma gondii	exonuclease III APE	0.0018	0.0207	0.3112
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0422	0.1283
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.004	0.0642	0.2492
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0504	1	1
Entamoeba histolytica	hypothetical protein	0.004	0.0642	0.2492
Schistosoma mansoni	dishevelled	0.0009	0.001	0.0031
Schistosoma mansoni	kinase	0.0053	0.0911	0.2774
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0642	0.1953
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0079	0.142	0.142
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0207	0.063
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0727	0.2212
Echinococcus multilocularis	ferritin	0.0009	0.0026	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.1952	0.432
Onchocerca volvulus		0.0231	0.4485	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0727	0.2212
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3829	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0642	0.1953
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0341	0.1037
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0883	0.1923
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0207	0.063
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0256	0.499	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0642	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3379	0.3379
Echinococcus granulosus	ferritin	0.0009	0.0026	0.0078
Leishmania major	hypothetical protein, conserved	0.004	0.0642	0.1271
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Echinococcus granulosus	zinc finger protein	0.0022	0.0274	0.0835
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0727	0.2212
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0207	0.0078
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0641	0.195
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.001	0.0031
Schistosoma mansoni	ap endonuclease	0.0018	0.0207	0.063
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0218	0.0663
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0232	0.0232
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0207	0.0406
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0642	1
Brugia malayi	hypothetical protein	0.004	0.0642	0.0642
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.001	0.0031
Loa Loa (eye worm)	hypothetical protein	0.004	0.0642	0.0642
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0642	0.1383
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0727	0.2212
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0504	1	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0105	0.1952	0.434
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0105	0.1952	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0642	0.1953
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0422	0.1283
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.001	0.0031
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0642	0.1955
Onchocerca volvulus		0.004	0.0642	0.1413
Brugia malayi	hypothetical protein	0.0009	0.001	0.001
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0207	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2241	0.2241
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.1952	0.5942
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.3379	0.7529
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0009	0.001	0.001
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0642	0.1242
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0218	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.001
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0105	0.1952	0.1952
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0207	0.0078
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.4485	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0341	0.1037
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0642	0.1383
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0105	0.1952	0.5942
Giardia lamblia	Kinase, PLK	0.0105	0.1952	1
Trypanosoma brucei	polo-like protein kinase	0.0105	0.1952	0.4858
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0207	0.0207

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 44 nM	Inhibition of human MCD	ChEMBL.	20832306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1258252

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1263263