Detailed information for compound 1263886

Basic information

Technical information
  • TDR Targets ID: 1263886
  • Name: 1-(4,6-dimethyl-3-methylsulfonylpyridin-2-yl) -1-methylhydrazine
  • MW: 229.299 | Formula: C9H15N3O2S
  • H donors: 1 H acceptors: 3 LogP: 0.56 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(n1)N(N)C)S(=O)(=O)C
  • InChi: 1S/C9H15N3O2S/c1-6-5-7(2)11-9(12(3)10)8(6)15(4,13)14/h5H,10H2,1-4H3
  • InChiKey: KNBWZSDZPYMPJG-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4,6-dimethyl-3-methylsulfonyl-2-pyridyl)-1-methyl-hydrazine
  • 1-(4,6-dimethyl-3-methylsulfonyl-2-pyridyl)-1-methylhydrazine
  • 1-(3-mesyl-4,6-dimethyl-2-pyridyl)-1-methyl-hydrazine
  • 1-(4,6-dimethyl-3-methylsulfonyl-pyridin-2-yl)-1-methyl-hydrazine
  • ZINC01387821
  • 4,6-dimethyl-2-(1-methylhydrazino)-3-(methylsulfonyl)pyridine
  • MLS000696036
  • SMR000334947
  • 10M-320S
  • Oprea1_713409

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis G protein coupled receptor 139 0.0088 0.0784 0.0986
Schistosoma mansoni amine GPCR 0.0088 0.0784 0.0885
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0088 0.0784 0.0885
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni neuropeptide receptor 0.0088 0.0784 0.0885
Brugia malayi Melatonin receptor type 1A 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0088 0.0784 0.0784
Brugia malayi G protein-coupled receptor 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0088 0.0784 0.0885
Echinococcus granulosus 7TM GPCR rhodopsin 0.0088 0.0784 0.0986
Echinococcus multilocularis voltage gated potassium channel 0.0092 0.091 0.1145
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0784 0.0986
Schistosoma mansoni histamine h1 receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0784 0.0986
Onchocerca volvulus 0.0114 0.1599 1
Schistosoma mansoni biogenic amine receptor 0.0088 0.0784 0.0885
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0784 0.0986
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0296 0.7295 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6728 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) TYRA-2 protein 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0088 0.0784 0.0885
Brugia malayi follicle stimulating hormone receptor 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0296 0.7295 1
Brugia malayi Dopamine receptor 0.0088 0.0784 0.0784
Brugia malayi ORL1-like opioid receptor 0.0088 0.0784 0.0784
Brugia malayi G-protein coupled receptor 0.0088 0.0784 0.0784
Brugia malayi G protein-coupled receptor F59B2.13 0.0088 0.0784 0.0784
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.4193 0.4193
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0784 0.0986
Schistosoma mansoni alpha-glucosidase 0.0169 0.3336 0.3767
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0317 0.7946 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni amine GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0088 0.0784 0.0784
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0088 0.0784 0.0784
Brugia malayi putative neuropeptide receptor 0.0088 0.0784 0.0784
Brugia malayi Cytochrome P450 family protein 0.0382 1 1
Mycobacterium leprae putative cytochrome p450 0.0173 0.3457 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0784 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Brugia malayi Cytochrome P450 family protein 0.0173 0.3457 0.3457
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0092 0.091 0.091
Echinococcus granulosus serotonin receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis 0.0173 0.3457 0.435
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis neuropeptide receptor 0.0088 0.0784 0.0986
Schistosoma mansoni growth hormone secretagogue receptor 0.0088 0.0784 0.0885
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0784 0.0986
Toxoplasma gondii cytochrome p450 superfamily protein 0.0173 0.3457 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0088 0.0784 0.0986
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus multilocularis G-protein coupled receptor, putative 0.0088 0.0784 0.0986
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0088 0.0784 0.0986
Echinococcus multilocularis orexin receptor type 2 0.0088 0.0784 0.0986
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0784 0.0986
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0784 0.0986
Echinococcus granulosus voltage gated potassium channel 0.0092 0.091 0.1145
Echinococcus multilocularis neuropeptide receptor A26 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni hypothetical protein 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi neuropeptide F receptor 0.0088 0.0784 0.0784
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Brugia malayi putative neuropeptide receptor NPR1 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0275 0.6638 0.6638
Echinococcus granulosus 7tm_1 domain containing protein 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0784 0.0784
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0088 0.0784 0.0986
Schistosoma mansoni hypothetical protein 0.0088 0.0784 0.0885
Schistosoma mansoni neuropeptide receptor 0.0088 0.0784 0.0885
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0088 0.0784 0.0986
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0382 1 1
Echinococcus granulosus g protein coupled receptor 0.0088 0.0784 0.0986
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0784 0.0784
Echinococcus granulosus neuropeptide receptor A26 0.0088 0.0784 0.0986
Schistosoma mansoni neuropeptide f receptor 76f 0.0088 0.0784 0.0885
Echinococcus granulosus fmrfamide receptor 0.0088 0.0784 0.0986
Brugia malayi RE15519p 0.0088 0.0784 0.0784
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0092 0.091 0.1145
Brugia malayi Serotonin receptor 0.0088 0.0784 0.0784
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0784 0.0986
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.091 0.1028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4193 0.5277
Schistosoma mansoni alpha-1 adrenergic receptor 0.0088 0.0784 0.0885
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.4193 0.4193
Echinococcus multilocularis serotonin receptor 0.0088 0.0784 0.0986
Echinococcus granulosus allatostatin A receptor 0.0088 0.0784 0.0986
Echinococcus granulosus g protein coupled receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0784 0.0986
Schistosoma mansoni hypothetical protein 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus neuropeptide FF receptor 2 0.0088 0.0784 0.0986
Echinococcus granulosus g protein coupled receptor 0.0088 0.0784 0.0986
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0088 0.0784 0.0885
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Loa Loa (eye worm) cytochrome P450 family protein 0.0382 1 1
Echinococcus granulosus orexin receptor type 2 0.0088 0.0784 0.0986
Echinococcus multilocularis neuropeptide receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0088 0.0784 0.0784
Loa Loa (eye worm) CYP4Cod1 0.0382 1 1
Brugia malayi sulfakinin receptor protein 0.0088 0.0784 0.0784
Echinococcus granulosus sex peptide receptor 0.0088 0.0784 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Schistosoma mansoni hypothetical protein 0.0173 0.3457 0.3903
Schistosoma mansoni hypothetical protein 0.0088 0.0784 0.0885
Leishmania major cytochrome p450-like protein 0.0382 1 1
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi cytochrome P450 0.0173 0.3457 0.3457
Echinococcus granulosus dro:myosuppressin receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0346 0.8856 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0092 0.091 0.091
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0088 0.0784 0.0986
Trypanosoma cruzi cytochrome P450, putative 0.0382 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.4193 0.5277
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0088 0.0784 0.0885
Echinococcus granulosus hypothetical protein 0.0088 0.0784 0.0986
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0088 0.0784 0.0986
Schistosoma mansoni alpha-glucosidase 0.0169 0.3336 0.3767
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4193 0.5277
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus granulosus G protein coupled receptor 139 0.0088 0.0784 0.0986
Loa Loa (eye worm) cytochrome P450 0.0173 0.3457 0.3457
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0088 0.0784 0.0986
Echinococcus granulosus tachykinin peptides receptor 99D 0.0088 0.0784 0.0986
Echinococcus granulosus neuropeptide receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) cytochrome P450 family protein 0.0173 0.3457 0.3457
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0088 0.0784 0.0784
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0784 0.0986
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni neuropeptide receptor 0.0088 0.0784 0.0885
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0317 0.7946 1
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Schistosoma mansoni amine GPCR 0.0088 0.0784 0.0885
Brugia malayi Dopamine receptor protein 1 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni amine GPCR 0.0088 0.0784 0.0885
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0088 0.0784 0.0885
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0784 0.0986
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0088 0.0784 0.0885
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Trypanosoma brucei cytochrome P450, putative 0.0382 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis g-protein coupled receptor 0.0088 0.0784 0.0986
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0784 0.0986
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0784 0.0885
Brugia malayi larval opioid receptor 0.0088 0.0784 0.0784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0088 0.0784 0.0885
Echinococcus granulosus peptide allatostatin:somatostatin 0.0088 0.0784 0.0986
Echinococcus granulosus neuropeptide receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Mycobacterium leprae Conserved hypothetical protein 0.0173 0.3457 0.5
Brugia malayi G-protein coupled receptor 0.0088 0.0784 0.0784
Brugia malayi neuropeptide F receptor 0.0088 0.0784 0.0784
Schistosoma mansoni amine GPCR 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0784 0.0986
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0784 0.0885
Schistosoma mansoni voltage-gated potassium channel 0.0346 0.8856 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0088 0.0784 0.0784
Schistosoma mansoni neuropeptide receptor 0.0088 0.0784 0.0885
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0784 0.0986
Echinococcus granulosus cytochrome P450 2K1 0.0173 0.3457 0.435
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0088 0.0784 0.0986
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0784 0.0986
Echinococcus granulosus somatostatin receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0088 0.0784 0.0784
Schistosoma mansoni opsin-like receptor 0.0088 0.0784 0.0885
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0784 0.0885
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0784 0.0986
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0088 0.0784 0.0986
Echinococcus granulosus neuropeptide s receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) melatonin receptor type 1A 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis somatostatin receptor 0.0088 0.0784 0.0986
Schistosoma mansoni myosin xvIII 0.0088 0.0784 0.0885
Schistosoma mansoni biogenic amine receptor 0.0088 0.0784 0.0885
Echinococcus multilocularis neuropeptide FF receptor 2 0.0088 0.0784 0.0986
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis sex peptide receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis neuropeptide s receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) cytochrome P450 family protein 0.0382 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Brugia malayi hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus g-protein coupled receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis dro:myosuppressin receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0784 0.0986
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.091 0.1028
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0317 0.7946 0.7946
Brugia malayi Dopamine receptor protein 2 0.0088 0.0784 0.0784
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0784 0.0885
Schistosoma mansoni opsin-like receptor 0.0088 0.0784 0.0885
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0784 0.0885
Brugia malayi Cytochrome P450 family protein 0.0173 0.3457 0.3457
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0092 0.091 0.1145
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0784 0.0986
Brugia malayi Serotonin receptor 0.0088 0.0784 0.0784
Echinococcus granulosus alpha 1A adrenergic receptor 0.0088 0.0784 0.0986
Schistosoma mansoni opsin-like receptor 0.0088 0.0784 0.0885
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0784 0.0986
Schistosoma mansoni cytochrome P450 0.0173 0.3457 0.3903
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0784 0.0986
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0784 0.0986
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0784 0.0885
Loa Loa (eye worm) hypothetical protein 0.0209 0.4583 0.4583
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0088 0.0784 0.0784
Echinococcus multilocularis serotonin receptor 0.0088 0.0784 0.0986
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Echinococcus multilocularis allatostatin A receptor 0.0088 0.0784 0.0986
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Schistosoma mansoni adenoreceptor 0.0088 0.0784 0.0885
Brugia malayi AKH receptor 0.0088 0.0784 0.0784
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0088 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0088 0.0784 0.0784
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0784 0.0986
Brugia malayi GnHR receptor homolog 0.0088 0.0784 0.0784
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0317 0.7946 0.7946
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0784 0.0784
Trypanosoma cruzi cytochrome P450, putative 0.0382 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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