Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Nicotiana tabacum | Zn finger protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium berghei | HSP40, subfamily A, putative | Zn finger protein | 234 aa | 201 aa | 21.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.3567 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0603 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0603 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3567 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0603 | 0 | 0.5 |
Onchocerca volvulus | 0.0603 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.3567 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3567 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3567 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0603 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3567 | 1 | 1 |
Onchocerca volvulus | 0.0603 | 0 | 0.5 | |
Onchocerca volvulus | 0.0603 | 0 | 0.5 | |
Onchocerca volvulus | 0.0603 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0603 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3567 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3567 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3567 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0603 | 0 | 0.5 |
Onchocerca volvulus | 0.0603 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3567 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 33.2 nM | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 21067924 |
Ki (binding) | = 46.7 nM | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 21067924 |
Ki (binding) | > 100 uM | Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method | ChEMBL. | 21067924 |
Ki (binding) | > 100 uM | Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration method | ChEMBL. | 21067924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.