Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.014 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1705 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.014 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.014 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1705 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.014 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1705 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1705 | 0.1705 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1705 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1705 | 0.1705 |
Loa Loa (eye worm) | carboxylesterase | 0.014 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1705 | 0.1705 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1705 | 0.1705 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.014 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1705 | 0.1705 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.014 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.