Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0169 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0169 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0048 | 0.208 | 0.208 |
Echinococcus granulosus | histone deacetylase 8 | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0048 | 0.208 | 0.208 |
Plasmodium falciparum | histone deacetylase 1 | 0.0169 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1255 | 0.1255 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.4277 | 0.4277 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.2336 | 0.2336 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.4277 | 0.4277 |
Leishmania major | histone deacetylase, putative | 0.0169 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0048 | 0.208 | 0.208 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0169 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0169 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0048 | 0.208 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.4277 | 0.4277 |
Trypanosoma brucei | histone deacetylase 1 | 0.0169 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0169 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0169 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.4277 | 0.4277 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0048 | 0.208 | 0.208 |
Brugia malayi | Histone deacetylase family protein | 0.0048 | 0.208 | 0.208 |
Echinococcus granulosus | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0169 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.2336 | 0.2336 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4277 | 0.4277 |
Entamoeba histolytica | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0048 | 0.208 | 0.208 |
Brugia malayi | Histone deacetylase 1 | 0.0169 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0048 | 0.208 | 0.208 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0169 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.2336 | 0.2336 |
Echinococcus granulosus | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Echinococcus granulosus | histone deacetylase 3 | 0.0169 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.4277 | 0.4277 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0169 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0048 | 0.208 | 0.208 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.4277 | 0.4277 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0048 | 0.208 | 0.208 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1255 | 0.1255 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.4277 | 0.4277 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0169 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0048 | 0.208 | 0.208 |
Echinococcus granulosus | histone deacetylase | 0.0048 | 0.208 | 0.208 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.4277 | 0.4277 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.4277 | 0.4277 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2336 | 0.2336 |
Echinococcus granulosus | histone deacetylase 7 | 0.0048 | 0.208 | 0.208 |
Echinococcus multilocularis | histone deacetylase | 0.0048 | 0.208 | 0.208 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0169 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0169 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0048 | 0.208 | 0.208 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0169 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1255 | 0.1255 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0169 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0169 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4277 | 0.4277 |
Echinococcus granulosus | histone deacetylase 6 | 0.0048 | 0.208 | 0.208 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.4277 | 0.4277 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.4277 | 0.4277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.2 uM/L | Inhibition of human acetyl cholinesterase by Ellmann's method | ChEMBL. | 20951037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.