Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | UDP-3-O-acyl-GlcNAc deacetylase | No references | |
Homo sapiens | core-binding factor, beta subunit | No references | |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references | |
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | runt-related transcription factor 1 | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0084 | 0.0128 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0259 | 0.0462 |
Brugia malayi | Adenosylhomocysteinase | 0.0385 | 0.4358 | 0.715 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0.1114 | 0.2557 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9046 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0043 | 0.0384 | 0.0621 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.0399 | 0.071 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0121 | 0.1286 | 0.2952 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.1884 | 0.4322 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.398 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0399 | 0.071 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0259 | 0.0462 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0307 | 0.0546 |
Brugia malayi | hypothetical protein | 0.0535 | 0.6094 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0399 | 0.0916 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0064 | 0.0113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0523 | 0.093 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0057 | 0.0084 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2258 | 0.4019 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0385 | 0.4358 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.066 | 0.1175 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0385 | 0.4358 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0523 | 0.093 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.0345 | 0.0791 |
Brugia malayi | Dihydrofolate reductase | 0.0043 | 0.0384 | 0.0624 |
Schistosoma mansoni | dihydrofolate reductase | 0.0043 | 0.0384 | 0.0683 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0284 | 0.0459 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.0399 | 0.0646 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0043 | 0.0384 | 0.0881 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0259 | 0.0462 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0307 | 0.0546 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.1114 | 0.1983 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2258 | 0.4019 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0307 | 0.0546 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0084 | 0.0131 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0043 | 0.0384 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6094 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0399 | 1 |
Loa Loa (eye worm) | runx1 | 0.0067 | 0.066 | 0.1075 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0307 | 0.0546 |
Echinococcus granulosus | dihydrofolate reductase | 0.0043 | 0.0384 | 0.0683 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.0345 | 0.0791 |
Echinococcus granulosus | geminin | 0.0205 | 0.2258 | 0.4019 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2258 | 0.4019 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0051 | 0.0468 | 0.1073 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0385 | 0.4358 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0006 | 0.001 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0523 | 0.093 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0385 | 0.4358 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.1114 | 0.2557 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0259 | 0.0462 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0006 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0064 | 0.0095 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0399 | 0.071 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.1617 | 0.3076 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.1114 | 0.1821 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0385 | 0.4358 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0259 | 0.0462 |
Brugia malayi | dihydrofolate reductase family protein | 0.0043 | 0.0384 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0259 | 0.0417 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0385 | 0.4358 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.1617 | 0.3076 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0385 | 0.4358 | 0.7149 |
Onchocerca volvulus | 0.0535 | 0.6094 | 1 | |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.5618 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.5618 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0284 | 0.0505 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0523 | 0.093 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0043 | 0.0384 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0252 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0057 | 0.0084 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0385 | 0.4358 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0284 | 0.0457 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0523 | 0.0852 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0523 | 0.0849 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0043 | 0.0384 | 0.0881 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0106 | 0.1114 | 0.2557 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0385 | 0.4358 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.0399 | 0.0916 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0051 | 0.0468 | 0.0173 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0259 | 0.0417 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0259 | 0.0462 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0239 | 0.2652 | 0.472 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0385 | 0.4358 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0385 | 0.4358 | 0.7757 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.1114 | 0.1823 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0259 | 0.0462 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0468 | 0.0761 |
Onchocerca volvulus | 0.0035 | 0.0284 | 0.0042 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0644 | 0.0619 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0385 | 0.4358 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.1114 | 0.1983 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.1617 | 0.3076 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.5618 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0239 | 0.2652 | 0.472 |
Schistosoma mansoni | lamin | 0.0033 | 0.0259 | 0.0462 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.1617 | 0.3076 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6094 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0399 | 0.0916 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0385 | 0.4358 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9046 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.1114 | 0.1983 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.0399 | 0.071 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0385 | 0.4358 | 0.7757 |
Echinococcus granulosus | lamin | 0.0033 | 0.0259 | 0.0462 |
Schistosoma mansoni | lozenge | 0.0067 | 0.066 | 0.1175 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0385 | 0.4358 | 0.7757 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0259 | 0.0419 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0259 | 0.0417 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0385 | 0.4358 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0735 | 0.1309 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.398 | 0.9134 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0239 | 0.2652 | 0.472 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0385 | 0.4358 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0259 | 0.0419 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0468 | 0.1073 |
Onchocerca volvulus | 0.0106 | 0.1114 | 0.1465 | |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.398 | 1 |
Brugia malayi | Inositol-1 | 0.0045 | 0.0399 | 0.0649 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0523 | 0.093 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0523 | 0.093 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.1884 | 0.4322 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.1884 | 0.4322 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0239 | 0.2652 | 0.472 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0399 | 0.0916 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0523 | 0.093 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0064 | 0.0113 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0385 | 0.4358 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.28 nM | BindingDB_Patents: Enzyme Assay. IC50 determination in the LpxC enzyme assay was carried out in a similar manner to that described by Malikzay et al in the 2006 Poster, Screening LpxC (UDP-3-O(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using BioTrove Rapid Fire HTS Mass Spectrometry (aNew Lead Discovery and bInflammation and Infectious Disease, cStructural Chemistry, Schering-Plough Research Institute, Kenilworth, N.J. 07033, (BioTrove, Inc. 12 Gill St., Suite 4000, Woburn, Mass. 01801). Briefly, Pseudomonas aeruginosa LpxC enzyme (0.1 nM) purified from E. coli-overexpressing bacteria was incubated at 25° C. in a final volume of 50 ul containing 0.5 uM UDP-3-O(R-3-hydroxydecanoyl)-N-acetylglucosamine, 1 mg/mL BSA, and 50 mM sodium phosphate buffer, pH 8.0 in the presence and absence of inhibitor compound. At the end of 1 hour, 5 ul of 1N HCl was added to stop the enzyme reaction; the plates were centrifuged, and then processed with the BioTrove Rapidfire HTMS Mass Spectrometry System. | ChEMBL. | No reference |
IC50 (binding) | = 3.28 nM | BindingDB_Patents: Enzyme Assay. IC50 determination in the LpxC enzyme assay was carried out in a similar manner to that described by Malikzay et al in the 2006 Poster, Screening LpxC (UDP-3-O(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using BioTrove Rapid Fire HTS Mass Spectrometry (aNew Lead Discovery and bInflammation and Infectious Disease, cStructural Chemistry, Schering-Plough Research Institute, Kenilworth, N.J. 07033, (BioTrove, Inc. 12 Gill St., Suite 4000, Woburn, Mass. 01801). Briefly, Pseudomonas aeruginosa LpxC enzyme (0.1 nM) purified from E. coli-overexpressing bacteria was incubated at 25° C. in a final volume of 50 ul containing 0.5 uM UDP-3-O(R-3-hydroxydecanoyl)-N-acetylglucosamine, 1 mg/mL BSA, and 50 mM sodium phosphate buffer, pH 8.0 in the presence and absence of inhibitor compound. At the end of 1 hour, 5 ul of 1N HCl was added to stop the enzyme reaction; the plates were centrifuged, and then processed with the BioTrove Rapidfire HTMS Mass Spectrometry System. | ChEMBL. | No reference |
IC50 (binding) | < 0.195 uM | PUBCHEM_BIOASSAY: uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. Inhibition of protein-protein interaction using fluorescence resonance energy transfer (FRET) assay Secondary Screen (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1438, AID1496, AID1502, AID1550, AID1560, AID1645] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: Identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a time resolved fluorescence resonance energy transfer (TR-FRET) assay. Counterscreen (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1434, AID1496, AID1502, AID1550, AID1560, AID1645] | ChEMBL. | No reference |
Potency (functional) | = 0.0126 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7407 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 24.9271 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] | ChEMBL. | No reference |
Potency (functional) | 42.5615 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.