Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4255 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1255 | 0.2949 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4255 | 0.4255 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2872 | 0.2872 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4255 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4255 | 0.4255 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4255 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4255 | 0.4255 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4255 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2872 | 0.2872 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4255 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4255 | 0.4255 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0022 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2872 | 0.2872 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4255 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2872 | 0.2872 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1255 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1255 | 0.1255 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4255 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4255 | 0.4255 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4255 | 0.4255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.