Detailed information for compound 1265284

Basic information

Technical information
  • TDR Targets ID: 1265284
  • Name: 2-[[4-amino-5-[4-(difluoromethoxy)phenyl]-1,2 ,4-triazol-3-yl]sulfanyl]-N-[(2,4-dimethylphe nyl)carbamoyl]acetamide
  • MW: 462.473 | Formula: C20H20F2N6O3S
  • H donors: 3 H acceptors: 4 LogP: 4.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(=O)Nc1ccc(cc1C)C)CSc1nnc(n1N)c1ccc(cc1)OC(F)F
  • InChi: 1S/C20H20F2N6O3S/c1-11-3-8-15(12(2)9-11)24-19(30)25-16(29)10-32-20-27-26-17(28(20)23)13-4-6-14(7-5-13)31-18(21)22/h3-9,18H,10,23H2,1-2H3,(H2,24,25,29,30)
  • InChiKey: LWPGJTJYHFQXNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-amino-5-[4-(difluoromethoxy)phenyl]-1,2,4-triazol-3-yl]thio]-N-[[(2,4-dimethylphenyl)amino]-oxomethyl]acetamide
  • 2-[[4-amino-5-[4-(difluoromethoxy)phenyl]-1,2,4-triazol-3-yl]thio]-N-[(2,4-dimethylphenyl)carbamoyl]acetamide
  • 2-[[4-amino-5-[4-(difluoromethoxy)phenyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2,4-dimethylphenyl)carbamoyl]ethanamide
  • SMR000261967
  • MLS000394518

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0434 0.1586
Loa Loa (eye worm) hypothetical protein 0.0104 0.1105 0.4045
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0336 0.0763
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0369 0.1065
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Onchocerca volvulus 0.0052 0.0434 0.2214
Echinococcus multilocularis expressed conserved protein 0.0098 0.1023 0.1022
Echinococcus granulosus expressed conserved protein 0.0098 0.1023 0.2333
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3449 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.1148
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0082 0.324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0937 0.3426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.027 0.0613
Loa Loa (eye worm) hypothetical protein 0.0148 0.1673 0.6127
Schistosoma mansoni hypothetical protein 0.0036 0.0224 0.0815
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.025 0.0916
Brugia malayi jmjC domain containing protein 0.0034 0.0203 0.0998
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0082 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.025 0.0722
Brugia malayi PHD-finger family protein 0.0028 0.0126 0.0615
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.025 0.0567
Toxoplasma gondii ABC1 family protein 0.0038 0.025 0.4171
Trichomonas vaginalis esterase, putative 0.0038 0.025 0.0722
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0369 1
Giardia lamblia PHD finger protein 15 0.0028 0.0126 0.0361
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.025 0.0861
Onchocerca volvulus 0.0038 0.025 0.1057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.044 0.2167
Leishmania major hypothetical protein, conserved 0.003 0.014 0.5581
Schistosoma mansoni patched 1 0.0045 0.0336 0.1225
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.025 0.0861
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.014 0.3307
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.025 0.0861
Schistosoma mansoni hypothetical protein 0.0123 0.1353 0.4949
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.025 0.123
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.1105 0.1104
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.025 0.0861
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0369 0.1065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0937 0.2135
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0082 0.0525
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0937 0.4624
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0224 0.11
Plasmodium vivax hypothetical protein, conserved 0.0038 0.025 0.59
Echinococcus multilocularis protein patched 0.0045 0.0336 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.2024 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0937 0.2135
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.025 0.0722
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.1148
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0937 0.3429
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0082 0.0234
Echinococcus granulosus peregrin 0.0033 0.0181 0.0411
Echinococcus granulosus tumor protein p63 0.0357 0.4381 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0716 0.2617
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Onchocerca volvulus Alhambra homolog 0.0028 0.0126 0.0275
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.2905 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.025 0.1138
Loa Loa (eye worm) hypothetical protein 0.0052 0.0434 0.159
Mycobacterium leprae conserved hypothetical protein 0.0038 0.025 0.1138
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0964 0.2197
Brugia malayi hypothetical protein 0.0038 0.025 0.1229
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0082 0.0399
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0082 0.324
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.1148
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0336 0.0763
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0001 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.014 0.3805
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.023 0.2732 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.1683 0.1682
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1961 0.4473
Brugia malayi hypothetical protein 0.003 0.014 0.0687
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.025 0.1603
Brugia malayi jmjC domain containing protein 0.0093 0.0964 0.4757
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0001 0.0005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0937 0.3426
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.082
Brugia malayi beta-lactamase family protein 0.0038 0.025 0.123
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3449 0.5
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0082 0.0399
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0203 0.0461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.025 0.0249
Loa Loa (eye worm) hypothetical protein 0.0045 0.0336 0.1229
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.2024 0.2023
Loa Loa (eye worm) beta-lactamase 0.0038 0.025 0.0916
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0126 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0424 0.1226
Loa Loa (eye worm) hypothetical protein 0.0055 0.0466 0.1705
Brugia malayi hypothetical protein 0.0106 0.1125 0.5554
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0001 0.0009
Echinococcus multilocularis protein dispatched 1 0.0051 0.0417 0.0416
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0126 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.025 1
Brugia malayi hypothetical protein 0.0148 0.1673 0.8266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.03
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.1148
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0424 0.0965
Schistosoma mansoni hypothetical protein 0.0028 0.0126 0.0456
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1561 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.025 0.1603
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0082 0.0399
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.025 0.0722
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.025 0.0861
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.014 0.5581
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.025 0.0861
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.044 0.161
Brugia malayi hypothetical protein 0.0019 0.0005 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0424 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.044 0.2167
Brugia malayi beta-lactamase 0.0038 0.025 0.123
Entamoeba histolytica hypothetical protein 0.0038 0.025 0.0721
Entamoeba histolytica hypothetical protein 0.0038 0.025 0.0721
Mycobacterium ulcerans hypothetical protein 0.0025 0.0082 0.0525
Loa Loa (eye worm) acetyltransferase 0.0175 0.2024 0.7411
Mycobacterium tuberculosis Conserved protein 0.0038 0.025 0.0861
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.025 0.0249
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.1105 0.5455
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0126 0.0461
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.025 0.0912
Onchocerca volvulus Huntingtin homolog 0.0148 0.1673 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0203 0.074
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0001 0.0005
Entamoeba histolytica hypothetical protein 0.0038 0.025 0.0721
Mycobacterium ulcerans beta-lactamase 0.0038 0.025 0.1603
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0082 0.0282
Onchocerca volvulus 0.0038 0.025 0.1057
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0964 0.0962
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.025 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.025 0.0861
Echinococcus granulosus leukotriene A 4 hydrolase 0.023 0.2732 0.6233
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.1126 0.4118
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.025 0.1842
Echinococcus multilocularis tumor protein p63 0.0357 0.4381 0.438
Mycobacterium ulcerans lipase LipD 0.0038 0.025 0.1603
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0082 0.0525
Loa Loa (eye worm) hypothetical protein 0.0049 0.0389 0.1424
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0082 0.0525
Brugia malayi Bromodomain containing protein 0.0033 0.0181 0.089
Onchocerca volvulus 0.0038 0.025 0.1057
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3449 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1673 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0203 0.074
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.2024 0.7409
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0082 0.0525
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.1683 0.3839
Brugia malayi beta-lactamase family protein 0.0038 0.025 0.123
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0082 0.0525
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0424 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0336 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0082 0.0525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0937 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0937 0.3426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.025 0.0912
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.03
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.014 0.5581
Mycobacterium tuberculosis Conserved protein 0.0038 0.025 0.0861
Echinococcus multilocularis jumonji domain containing protein 0.004 0.027 0.0269
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1561 0.5373
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0082 0.324
Entamoeba histolytica hypothetical protein 0.0038 0.025 0.0721
Echinococcus multilocularis peregrin 0.0033 0.0181 0.018
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0082 0.0234
Brugia malayi CHE-14 protein 0.0045 0.0336 0.1653
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0082 0.0525
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1561 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.1105 0.32
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0203 0.0744
Leishmania major hypothetical protein, conserved 0.0038 0.025 1
Trypanosoma brucei RNA helicase, putative 0.0123 0.1353 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.023 0.2732 0.2731
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3449 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Loa Loa (eye worm) hypothetical protein 0.0148 0.1673 0.6127
Mycobacterium tuberculosis Conserved protein 0.0038 0.025 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.025 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.025 0.0722
Schistosoma mansoni hypothetical protein 0.0038 0.025 0.091
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0518 0.1896
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.025 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0336 0.097
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0336 0.1229
Loa Loa (eye worm) hypothetical protein 0.0053 0.044 0.161
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0126 0.2967
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.014 0.0484
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0126 0.0124
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.014 0.1028
Loa Loa (eye worm) leukotriene A4 hydrolase 0.023 0.2732 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0082 0.0282
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.1105 0.2519
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.014 0.3805
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0424 1
Plasmodium falciparum phd finger protein, putative 0.0028 0.0126 0.3414
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0203 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3449 1
Loa Loa (eye worm) hypothetical protein 0.003 0.014 0.0514
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.025 0.091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0424 0.1226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0937 0.0935
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0916
Mycobacterium ulcerans hypothetical protein 0.0038 0.025 0.1603

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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