Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0198 | 0.7232 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.1418 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0198 | 0.7232 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0198 | 0.7232 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.1418 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.027 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1418 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0198 | 0.7232 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.1418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Brugia malayi | beta-lactamase | 0.0041 | 0.027 | 0.1908 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.027 | 0.1908 |
Onchocerca volvulus | 0.0041 | 0.027 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1418 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.1418 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.027 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0198 | 0.7232 | 1 |
Onchocerca volvulus | 0.0041 | 0.027 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.027 | 0.1908 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.027 | 0.1908 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.027 | 0.0374 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.027 | 0.1908 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1418 | 1 |
Onchocerca volvulus | 0.0041 | 0.027 | 1 | |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.027 | 0.1908 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1418 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0198 | 0.7232 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.027 | 0.1908 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0198 | 0.7232 | 0.7155 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0198 | 0.7232 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.027 | 0.1908 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1418 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0198 | 0.7232 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.027 | 0.0374 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.027 | 0.1908 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1418 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.1418 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.027 | 0.1908 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.027 | 0.1908 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1418 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.511 | Antimetastatic activity against human PC3 cells after 24 hrs by wound-healing assay | ChEMBL. | 20869139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.