Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0.0885 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0885 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0885 | 0.0579 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0885 | 0.0579 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0885 | 0.0579 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0.0885 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Schistosoma mansoni | ferritin | 0.001 | 0.0885 | 0.0885 |
Schistosoma mansoni | ferritin | 0.001 | 0.0885 | 0.0885 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0885 | 0.0885 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0885 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 0.0885 | 0.0885 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0885 | 0.0885 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0885 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0.0885 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0.0885 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 0.0885 | 0.0885 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0885 | 0.0885 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0885 | 0.0885 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0754 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0.0885 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.6047 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 1 |
Echinococcus granulosus | ferritin | 0.001 | 0.0885 | 0.0579 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 0.6047 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0754 |
Onchocerca volvulus | 0.0035 | 0.4403 | 0.5 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.6047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.