Detailed information for compound 1265704

Basic information

Technical information
  • TDR Targets ID: 1265704
  • Name: 6-iodo-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]q uinoline-4-carboxylic acid
  • MW: 341.144 | Formula: C13H12INO2
  • H donors: 2 H acceptors: 2 LogP: 3.13 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1Nc2c(I)cccc2C2C1CC=C2
  • InChi: 1S/C13H12INO2/c14-10-6-2-5-8-7-3-1-4-9(7)12(13(16)17)15-11(8)10/h1-3,5-7,9,12,15H,4H2,(H,16,17)
  • InChiKey: CNQHYGCDWZHJEN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • Oprea1_633581
  • Oprea1_033158
  • A1859/0078198
  • MLS-0092009
  • MLS-0092009.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock 70kDa protein 8 Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 1B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 8 646 aa 577 aa 51.8 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 1B 641 aa 613 aa 49.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0004 1 0.5
Leishmania major heat-shock protein hsp70, putative 0.0004 1 0.5
Schistosoma mansoni heat shock protein 70 0.0004 1 0.5
Entamoeba histolytica 70 kDa heat shock protein, putative 0.0004 1 0.5
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis 0.0004 1 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0004 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0004 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0004 1 1
Echinococcus granulosus heat shock protein 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Brugia malayi heat shock 70 kDa protein C precursor 0.0004 1 0.5
Leishmania major heat-shock protein hsp70, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Entamoeba histolytica heat shock protein 70 family 0.0004 1 0.5
Leishmania major heat shock protein 70-related protein 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0004 1 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0004 1 0.5
Leishmania major glucose-regulated protein 78, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein 70kD, putative 0.0004 1 0.5
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0004 1 0.5
Plasmodium falciparum heat shock protein 70 0.0004 1 0.5
Loa Loa (eye worm) heat shock 70kDa protein 5 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 0.0004 1 0.5
Echinococcus multilocularis 0.0004 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Entamoeba histolytica heat shock protein 70, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Entamoeba histolytica hypothetical protein 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Giardia lamblia Cytosolic HSP70 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 related 0.0004 1 1
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0004 1 1
Echinococcus multilocularis heat shock protein 70 related 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis heat shock 70 kDa protein 1 0.0004 1 1
Plasmodium falciparum heat shock protein 70 0.0004 1 0.5
Plasmodium vivax heat shock 70 kDa protein, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0004 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0004 1 1
Entamoeba histolytica heat shock protein 70, putative 0.0004 1 0.5
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis heat shock kda protein 0.0004 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0004 1 1
Entamoeba histolytica heat shock protein 70 family 0.0004 1 0.5
Plasmodium falciparum heat shock protein 70 0.0004 1 0.5
Schistosoma mansoni heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis Heat Shock protein family member (hsp 3) 0.0004 1 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 71 kDa protein 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 0.0004 1 0.5
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70b 0.0004 1 1
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative 0.0004 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Entamoeba histolytica heat shock protein 70, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0004 1 1
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B 0.0004 1 1
Echinococcus granulosus heat shock protein 70b 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trypanosoma cruzi glucose-regulated protein 78, putative 0.0004 1 0.5
Giardia lamblia Bip 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 0.0004 1 1
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Entamoeba histolytica heat shock protein 70, putative 0.0004 1 0.5
Echinococcus granulosus Heat Shock protein family member hsp 3 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 related 0.0004 1 1
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Toxoplasma gondii chaperonin protein BiP 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus granulosus heat shock protein 71 kDa protein 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Onchocerca volvulus 0.0004 1 0.5
Trypanosoma brucei heat shock 70 kDa protein, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein 70kD, putative 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Trypanosoma brucei heat shock protein 70 (hsp70), putative 0.0004 1 0.5
Echinococcus granulosus heat shock protein kDa 0.0004 1 0.5
Echinococcus granulosus heat shock kda protein 0.0004 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0004 1 1
Echinococcus multilocularis heat shock 70 kda protein 1a 0.0004 1 1
Schistosoma mansoni heat shock protein 70 0.0004 1 0.5
Plasmodium vivax heat shock protein 70, putative 0.0004 1 0.5
Trypanosoma brucei heat shock protein 70 0.0004 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0004 1 0.5
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0004 1 0.5
Toxoplasma gondii heat shock protein HSP70 0.0004 1 0.5
Echinococcus granulosus heat shock protein 70 0.0004 1 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.13 um PUBCHEM_BIOASSAY: In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 786, 583 ] ChEMBL. No reference
IC50 (binding) = 14.1 um PUBCHEM_BIOASSAY: In Vitro Hsc70 Dose Response Fluorescence Polarization Assay. (Class of assay: confirmatory) [Related pubchem assays: 1072 ] ChEMBL. No reference
IC50 (binding) = 47.8 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 71.4 um PUBCHEM_BIOASSAY: In Vitro HePTP Dose Response Colorimetric Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 521 ] ChEMBL. No reference
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1054, AID1055, AID425, AID553, AID566] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: In Vitro MKP-3 Dose Response Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1052, AID1661, AID2085, AID2679, AID425, AID553, AID566] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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