TDR Targets

Basic information

Technical information

TDR Targets ID: 1265959
Name: N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl )phenyl]sulfonylmethyl]furan-2-carboxamide
MW: 429.453 | Formula: C20H22F3NO4S
H donors: 1 H acceptors: 3 LogP: 4.31 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCC(CC1)NC(=O)c1ccc(o1)CS(=O)(=O)c1cccc(c1)C(F)(F)F
InChi: 1S/C20H22F3NO4S/c1-13-5-7-15(8-6-13)24-19(25)18-10-9-16(28-18)12-29(26,27)17-4-2-3-14(11-17)20(21,22)23/h2-4,9-11,13,15H,5-8,12H2,1H3,(H,24,25)
InChiKey: XJWIGLRSHWSPIJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]sulfonylmethyl]-2-furancarboxamide
N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]sulfonylmethyl]-2-furamide
C521-1296
NCGC00109423-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0025	0.0157	0.5
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0156	0.4244	0.4152
Onchocerca volvulus		0.0072	0.1623	1
Schistosoma mansoni	amine GPCR	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1623	0.3032
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.157	0.157
Schistosoma mansoni	adenoreceptor	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0072	0.1623	0.2749
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.1263	0.1263
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0025	0.0157	0.0294
Schistosoma mansoni	cytochrome P450	0.0156	0.4244	0.7189
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.1623	0.2749
Schistosoma mansoni	growth hormone secretagogue receptor	0.0072	0.1623	0.2749
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0025	0.0157	0.0294
Echinococcus multilocularis	sex peptide receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0072	0.1623	0.2749
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0055	0.1101	0.2057
Onchocerca volvulus		0.0072	0.1623	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0072	0.1623	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0156	0.4244	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Onchocerca volvulus		0.0072	0.1623	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0191	0.5354	1
Loa Loa (eye worm)	cytochrome P450	0.0156	0.4244	0.4244
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0179	0.496	1
Trypanosoma cruzi	cytochrome P450, putative	0.034	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	amine GPCR	0.0072	0.1623	0.2749
Brugia malayi	Melatonin receptor type 1A	0.0072	0.1623	0.1623
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0025	0.0157	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0551	0.0934
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0156	0.4244	1
Schistosoma mansoni	amine GPCR	0.0072	0.1623	0.2749
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0025	0.0157	0.0267
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0025	0.0157	0.0157
Schistosoma mansoni	hypothetical protein	0.0156	0.4244	0.7189
Brugia malayi	Serotonin receptor	0.0072	0.1623	0.1623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0184	0.5123	0.5123
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0025	0.0157	0.0294
Echinococcus multilocularis		0.0156	0.4244	0.7927
Echinococcus multilocularis	voltage gated potassium channel	0.0055	0.1101	0.2057
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.1623	0.1623
Schistosoma mansoni	neuropeptide f receptor 76f	0.0072	0.1623	0.2749
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0156	0.4244	0.4244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Leishmania major	cathepsin L-like protease	0.0077	0.1779	0.1779
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0156	0.4244	1
Echinococcus multilocularis	somatostatin receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0072	0.1623	0.1623
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0072	0.1623	0.1623
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0025	0.0157	0.0157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.1623	0.3032
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0072	0.1623	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0551	0.0934
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1101	0.1101
Onchocerca volvulus		0.0072	0.1623	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	hypothetical protein	0.0072	0.1623	0.3032
Schistosoma mansoni	myosin xvIII	0.0072	0.1623	0.2749
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0551	0.103
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0025	0.0157	0.0317
Echinococcus granulosus	neuropeptide receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0072	0.1623	0.1623
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0025	0.0157	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0156	0.4244	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.1623	0.3032
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0072	0.1623	0.3032
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0156	0.4244	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0072	0.1623	0.3032
Loa Loa (eye worm)	melatonin receptor type 1A	0.0072	0.1623	0.1623
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0072	0.1623	0.2749
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0025	0.0157	0.0371
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.1623	0.3032
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0156	0.4244	0.4152
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	cGMP dependent protein kinase	0.0025	0.0157	0.0294
Echinococcus granulosus	orexin receptor type 2	0.0072	0.1623	0.3032
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0551	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1623	0.3032
Brugia malayi	Dopamine receptor protein 1	0.0072	0.1623	0.1623
Echinococcus granulosus	neuropeptide receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	voltage-gated potassium channel	0.0055	0.1101	0.1865
Echinococcus multilocularis	neuropeptide receptor	0.0072	0.1623	0.3032
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0156	0.4244	0.4152
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0025	0.0157	0.5
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0038	0.0551	0.103
Treponema pallidum	cyclic nucleotide binding protein	0.0025	0.0157	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0551	0.103
Leishmania major	protein kinase, putative	0.0025	0.0157	0.0157
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0025	0.0157	0.0267
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0025	0.0157	0.097
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.1623	0.3032
Trypanosoma cruzi	cytochrome P450, putative	0.034	1	1
Leishmania major	cytochrome p450-like protein	0.0156	0.4244	0.4244
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1779	0.1779
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.1623	0.1623
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0551	0.1112
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0156	0.4244	0.4152
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0025	0.0157	0.0294
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0156	0.4244	0.4152
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Onchocerca volvulus		0.0072	0.1623	1
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.1623	0.3032
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0179	0.496	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0551	0.103
Brugia malayi	AKH receptor	0.0072	0.1623	0.1623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0551	0.0934
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1623	0.3032
Echinococcus multilocularis	dro:myosuppressin receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0072	0.1623	0.2749
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0156	0.4244	0.4152
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0025	0.0157	0.0157
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	g-protein coupled receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	opsin-like receptor	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1623	0.2749
Trypanosoma cruzi	cAMP binding protein, putative	0.0025	0.0157	0.0157
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0025	0.0157	0.0157
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0072	0.1623	0.1623
Brugia malayi	G protein-coupled receptor	0.0072	0.1623	0.1623
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0072	0.1623	0.1623
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0072	0.1623	0.3032
Entamoeba histolytica	cysteine proteinase, putative	0.002	0	0.5
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0025	0.0157	0.0267
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0156	0.4244	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Leishmania major	hypothetical protein, conserved	0.0025	0.0157	0.0157
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0191	0.5354	0.5354
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0072	0.1623	0.3032
Treponema pallidum	catabolite gene activator (Crp)	0.0025	0.0157	0.5
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0156	0.4244	0.4152
Echinococcus granulosus	fmrfamide receptor	0.0072	0.1623	0.3032
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0156	0.4244	0.4152
Trypanosoma cruzi	cAMP response protein 1	0.0025	0.0157	0.0157
Brugia malayi	sulfakinin receptor protein	0.0072	0.1623	0.1623
Brugia malayi	Serotonin receptor	0.0072	0.1623	0.1623
Loa Loa (eye worm)	cytochrome P450 family protein	0.0156	0.4244	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0551	0.103
Echinococcus granulosus	voltage gated potassium channel	0.0055	0.1101	0.2057
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1623	0.3032
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0156	0.4244	1
Mycobacterium leprae	putative cytochrome p450	0.0156	0.4244	1
Schistosoma mansoni	hypothetical protein	0.0072	0.1623	0.2749
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0551	0.0934
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.1623	0.2749
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0025	0.0157	0.0294
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0072	0.1623	0.2749
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0156	0.4244	0.4152
Schistosoma mansoni	voltage-gated potassium channel	0.0209	0.5904	1
Leishmania major	cytochrome p450-like protein	0.034	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Leishmania major	cathepsin L-like protease	0.0077	0.1779	0.1779
Echinococcus granulosus	serotonin receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0072	0.1623	0.1623
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1623	0.3032
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0025	0.0157	0.0267
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0025	0.0157	0.0294
Brugia malayi	larval opioid receptor	0.0072	0.1623	0.1623
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0025	0.0157	0.0157
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0025	0.0157	0.0267
Onchocerca volvulus		0.0072	0.1623	1
Brugia malayi	GnHR receptor homolog	0.0072	0.1623	0.1623
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Onchocerca volvulus		0.0072	0.1623	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0072	0.1623	0.1623
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0551	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	histamine h1 receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0025	0.0157	0.0267
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Schistosoma mansoni	amine GPCR	0.0072	0.1623	0.2749
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0025	0.0157	0.0294
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0055	0.1101	0.1101
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1779	0.1779
Leishmania major	hypothetical protein, unknown function	0.0025	0.0157	0.0157
Echinococcus granulosus	dro:myosuppressin receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0157	0.0267
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0156	0.4244	1
Brugia malayi	neuropeptide F receptor	0.0072	0.1623	0.1623
Entamoeba histolytica	cysteine proteinase, putative	0.002	0	0.5
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0156	0.4244	0.4152
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0025	0.0157	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0156	0.4244	1
Leishmania major	protein kinase A regulatory subunit, putative	0.0025	0.0157	0.0157
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0156	0.4244	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0025	0.0157	0.0294
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0156	0.4244	1
Onchocerca volvulus		0.0072	0.1623	1
Loa Loa (eye worm)	TYRA-2 protein	0.0072	0.1623	0.1623
Schistosoma mansoni	voltage-gated potassium channel	0.0209	0.5904	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0157	0.0267
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0156	0.4244	1
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0191	0.5354	1
Brugia malayi	neuropeptide F receptor	0.0072	0.1623	0.1623
Onchocerca volvulus		0.0025	0.0157	0.097
Onchocerca volvulus		0.0072	0.1623	1
Onchocerca volvulus		0.0072	0.1623	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	cytochrome P450 family protein	0.034	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus granulosus	cytochrome P450 2K1	0.0156	0.4244	0.7927
Echinococcus multilocularis	neuropeptide s receptor	0.0072	0.1623	0.3032
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0156	0.4244	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1779	0.1779
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	7TM GPCR rhodopsin	0.0072	0.1623	0.3032
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0157	0.0267
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0025	0.0157	0.0157
Brugia malayi	RE15519p	0.0072	0.1623	0.1623
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0025	0.0157	0.0317
Schistosoma mansoni	hypothetical protein	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0025	0.0157	0.0267
Onchocerca volvulus		0.0072	0.1623	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1623	0.3032
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0156	0.4244	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0156	0.4244	0.4152
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0025	0.0157	0.0157
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	serotonin receptor	0.0072	0.1623	0.3032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.1623	0.3032
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1623	0.2749
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.1623	0.3032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1623	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0156	0.4244	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0156	0.4244	0.4152
Brugia malayi	putative neuropeptide receptor NPR1	0.0072	0.1623	0.1623
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	G protein coupled receptor 139	0.0072	0.1623	0.3032
Echinococcus granulosus	allatostatin A receptor	0.0072	0.1623	0.3032
Onchocerca volvulus		0.0072	0.1623	1
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0072	0.1623	0.3032
Echinococcus multilocularis	orexin receptor type 2	0.0072	0.1623	0.3032
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0072	0.1623	0.3032
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0025	0.0157	1
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0025	0.0157	0.0157
Treponema pallidum	cyclic nucleotide binding protein	0.0025	0.0157	0.5
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0025	0.0157	0.0267
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.1779	0.1779
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0551	0.103
Leishmania major	cytochrome p450-like protein	0.0156	0.4244	0.4244
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1623	0.3032
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	cytochrome P450 family protein	0.034	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1623	0.3032
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0072	0.1623	0.1623
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Echinococcus multilocularis	G protein coupled receptor 139	0.0072	0.1623	0.3032
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0072	0.1623	0.3032
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0025	0.0157	0.0294
Onchocerca volvulus		0.0072	0.1623	1
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0156	0.4244	0.4152
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0551	0.0934
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Entamoeba histolytica	cysteine protease, putative	0.002	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Echinococcus multilocularis	serotonin receptor	0.0072	0.1623	0.3032
Brugia malayi	Cytochrome P450 family protein	0.0156	0.4244	0.4244
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0025	0.0157	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0025	0.0157	0.0267
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0157	0.0157
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0025	0.0157	0.0267
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	g-protein coupled receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.1623	0.3032
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0038	0.0551	0.0551
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0156	0.4244	1
Brugia malayi	ORL1-like opioid receptor	0.0072	0.1623	0.1623
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0156	0.4244	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0025	0.0157	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0157	0.0317
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0156	0.4244	1
Echinococcus granulosus	somatostatin receptor	0.0072	0.1623	0.3032
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0072	0.1623	0.1623
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0025	0.0157	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0157	0.0157
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0157	0.0157
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0025	0.0157	0.0371
Onchocerca volvulus		0.0072	0.1623	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0156	0.4244	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0072	0.1623	0.3032
Brugia malayi	follicle stimulating hormone receptor	0.0072	0.1623	0.1623
Onchocerca volvulus		0.0072	0.1623	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Brugia malayi	Dopamine receptor protein 2	0.0072	0.1623	0.1623
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Treponema pallidum	catabolite gene activator	0.0025	0.0157	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0025	0.0157	0.0317
Schistosoma mansoni	amine GPCR	0.0072	0.1623	0.2749
Brugia malayi	G-protein coupled receptor	0.0072	0.1623	0.1623
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1623	0.2749
Echinococcus multilocularis	allatostatin A receptor	0.0072	0.1623	0.3032
Trypanosoma brucei	cytochrome P450, putative	0.034	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1623	0.2749
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0551	0.103
Echinococcus multilocularis	expressed conserved protein	0.0025	0.0157	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4563	0.4563
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0072	0.1623	0.3032
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1623	0.2749
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0025	0.0157	0.0371
Brugia malayi	Cytochrome P450 family protein	0.0156	0.4244	0.4244
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0025	0.0157	0.0317
Brugia malayi	Cytochrome P450 family protein	0.034	1	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0156	0.4244	0.4244
Schistosoma mansoni	60S ribosomal protein L21	0.003	0.0311	0.0526
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0156	0.4244	0.4152
Brugia malayi	putative neuropeptide receptor	0.0072	0.1623	0.1623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0551	0.1112
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	opsin-like receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0551	0.103
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0025	0.0157	0.0294
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0191	0.5354	0.5354
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.1623	0.1623
Echinococcus multilocularis	neuropeptide receptor	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0072	0.1623	0.3032
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0025	0.0157	0.0294
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0157	0.0267
Schistosoma mansoni	hypothetical protein	0.0072	0.1623	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Trypanosoma cruzi	Flagellar Member 6	0.0025	0.0157	0.0157
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1623	0.3032
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	neuropeptide s receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0072	0.1623	0.2749
Brugia malayi	cytochrome P450	0.0156	0.4244	0.4244
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0156	0.4244	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0055	0.1101	0.2057
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0156	0.4244	0.4152
Echinococcus granulosus	neuropeptide receptor A26	0.0072	0.1623	0.3032
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.1623	0.2749
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1623	0.2749
Plasmodium falciparum	cGMP-dependent protein kinase	0.0025	0.0157	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0072	0.1623	0.1623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0072	0.1623	0.2749
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0072	0.1623	0.3032
Onchocerca volvulus		0.0025	0.0157	0.097
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0156	0.4244	1
Schistosoma mansoni	voltage-gated potassium channel	0.003	0.0311	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Leishmania major	hypothetical protein, conserved	0.0025	0.0157	0.0157
Onchocerca volvulus		0.0072	0.1623	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.034	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0156	0.4244	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.1623	0.2749
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1623	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0156	0.4244	1
Mycobacterium leprae	Conserved hypothetical protein	0.0156	0.4244	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0551	0.0551
Leishmania major	protein kinase, putative	0.0025	0.0157	0.0157
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0025	0.0157	0.0157
Loa Loa (eye worm)	CYP4Cod1	0.034	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Brugia malayi	Dopamine receptor	0.0072	0.1623	0.1623
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0551	0.0551
Leishmania major	cathepsin L-like protease	0.0077	0.1779	0.1779
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	opsin-like receptor	0.0072	0.1623	0.2749
Schistosoma mansoni	voltage-gated potassium channel	0.0055	0.1101	0.1865
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0156	0.4244	0.4152
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0072	0.1623	0.3032
Brugia malayi	Egg laying defective protein 4	0.0025	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0072	0.1623	0.1623
Brugia malayi	N-terminal motif family protein	0.0025	0.0157	0.0157
Schistosoma mansoni	hypothetical protein	0.0072	0.1623	0.2749
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0156	0.4244	0.4152
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0025	0.0157	0.0294
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1623	0.2749
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0025	0.0157	0.0371
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1623	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0551	0.103
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0156	0.4244	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0072	0.1623	0.1623
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0025	0.0157	0.0371
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.1623	0.3032
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0551	0.103
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.1623	0.2749
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0156	0.4244	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0072	0.1623	0.3032
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0072	0.1623	0.3032
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0025	0.0157	0.0267
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0025	0.0157	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0072	0.1623	0.2749
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0156	0.4244	0.4152
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0038	0.0551	0.103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Brugia malayi	G-protein coupled receptor	0.0072	0.1623	0.1623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1623	0.3032
Trypanosoma cruzi	cAMP response protein 1, putative	0.0025	0.0157	0.0157
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0156	0.4244	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0025	0.0157	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1779	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1623	0.1623
Echinococcus granulosus	sex peptide receptor	0.0072	0.1623	0.3032
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1623	0.2749
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0025	0.0157	0.0157
Onchocerca volvulus		0.0072	0.1623	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1378874

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1265959