Detailed information for compound 1265959

Basic information

Technical information
  • TDR Targets ID: 1265959
  • Name: N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl )phenyl]sulfonylmethyl]furan-2-carboxamide
  • MW: 429.453 | Formula: C20H22F3NO4S
  • H donors: 1 H acceptors: 3 LogP: 4.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC(CC1)NC(=O)c1ccc(o1)CS(=O)(=O)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C20H22F3NO4S/c1-13-5-7-15(8-6-13)24-19(25)18-10-9-16(28-18)12-29(26,27)17-4-2-3-14(11-17)20(21,22)23/h2-4,9-11,13,15H,5-8,12H2,1H3,(H,24,25)
  • InChiKey: XJWIGLRSHWSPIJ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]sulfonylmethyl]-2-furancarboxamide
  • N-(4-methylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]sulfonylmethyl]-2-furamide
  • C521-1296
  • NCGC00109423-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus cGMP dependent protein kinase 1 0.0025 0.0157 0.0294
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0156 0.4244 0.4152
Schistosoma mansoni growth hormone secretagogue receptor 0.0072 0.1623 0.2749
Schistosoma mansoni neuropeptide receptor 0.0072 0.1623 0.2749
Leishmania major protein kinase A regulatory subunit, putative 0.0025 0.0157 0.0157
Loa Loa (eye worm) cytochrome P450 family protein 0.034 1 1
Echinococcus multilocularis neuropeptide receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.1623 0.3032
Onchocerca volvulus 0.0072 0.1623 1
Onchocerca volvulus 0.0072 0.1623 1
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi AKH receptor 0.0072 0.1623 0.1623
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0156 0.4244 0.4152
Echinococcus granulosus g protein coupled receptor 0.0072 0.1623 0.3032
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0156 0.4244 1
Loa Loa (eye worm) cytochrome P450 0.0156 0.4244 0.4244
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0025 0.0157 0.0157
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0025 0.0157 0.0267
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0156 0.4244 0.4152
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0025 0.0157 0.0267
Onchocerca volvulus 0.0072 0.1623 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0157 0.0267
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis dro:myosuppressin receptor 0.0072 0.1623 0.3032
Leishmania major cathepsin L-like protease 0.0077 0.1779 0.1779
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0072 0.1623 0.2749
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0072 0.1623 0.1623
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0156 0.4244 1
Schistosoma mansoni amine GPCR 0.0072 0.1623 0.2749
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0072 0.1623 0.1623
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.1101 0.2057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.1623 0.3032
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0157 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.1623 0.3032
Schistosoma mansoni amine GPCR 0.0072 0.1623 0.2749
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0038 0.0551 0.0934
Treponema pallidum catabolite gene activator 0.0025 0.0157 0.5
Schistosoma mansoni opsin-like receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) CYP4Cod1 0.034 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.0157 0.0294
Echinococcus granulosus hyperpolarization activated cyclic 0.0038 0.0551 0.103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0072 0.1623 0.3032
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0025 0.0157 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0551 0.0934
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0025 0.0157 0.0157
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0055 0.1101 0.1101
Echinococcus granulosus g protein coupled receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Echinococcus multilocularis fmrfamide receptor 0.0072 0.1623 0.3032
Echinococcus granulosus neuropeptide FF receptor 2 0.0072 0.1623 0.3032
Brugia malayi Melatonin receptor type 1A 0.0072 0.1623 0.1623
Echinococcus multilocularis voltage gated potassium channel 0.0055 0.1101 0.2057
Brugia malayi Dopamine receptor protein 1 0.0072 0.1623 0.1623
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0551 0.0934
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi neuropeptide F receptor 0.0072 0.1623 0.1623
Onchocerca volvulus 0.0072 0.1623 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1779 0.1779
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0156 0.4244 0.4152
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi Egg laying defective protein 4 0.0025 0.0157 0.0157
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0025 0.0157 0.0267
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0156 0.4244 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0072 0.1623 0.1623
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0072 0.1623 0.1623
Leishmania major cytochrome p450-like protein 0.0156 0.4244 0.4244
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0025 0.0157 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0157 0.0267
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0156 0.4244 0.4152
Brugia malayi Serotonin receptor 0.0072 0.1623 0.1623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Echinococcus granulosus voltage gated potassium channel 0.0055 0.1101 0.2057
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.1623 0.3032
Echinococcus granulosus 7TM GPCR rhodopsin 0.0072 0.1623 0.3032
Echinococcus granulosus somatostatin receptor 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0156 0.4244 0.4152
Loa Loa (eye worm) cytochrome P450 family protein 0.0156 0.4244 0.4244
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0072 0.1623 0.3032
Loa Loa (eye worm) AGC/PKG protein kinase 0.0025 0.0157 0.0157
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.1623 0.3032
Brugia malayi Dopamine receptor protein 2 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0025 0.0157 0.0157
Schistosoma mansoni voltage-gated potassium channel 0.0038 0.0551 0.0934
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0072 0.1623 0.1623
Schistosoma mansoni amine GPCR 0.0072 0.1623 0.2749
Loa Loa (eye worm) hypothetical protein 0.0166 0.4563 0.4563
Onchocerca volvulus 0.0072 0.1623 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0156 0.4244 0.4244
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0072 0.1623 0.2749
Onchocerca volvulus 0.0072 0.1623 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0156 0.4244 0.4152
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1779 0.1779
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0157 0.0157
Schistosoma mansoni biogenic amine receptor 0.0072 0.1623 0.2749
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Schistosoma mansoni myosin xvIII 0.0072 0.1623 0.2749
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0156 0.4244 1
Schistosoma mansoni amine GPCR 0.0072 0.1623 0.2749
Onchocerca volvulus 0.0072 0.1623 1
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.1623 0.3032
Onchocerca volvulus 0.0025 0.0157 0.097
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0156 0.4244 1
Onchocerca volvulus 0.0072 0.1623 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0025 0.0157 0.0371
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.1623 0.3032
Echinococcus multilocularis neuropeptide s receptor 0.0072 0.1623 0.3032
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0025 0.0157 0.0294
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0184 0.5123 0.5123
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.1623 0.3032
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0038 0.0551 0.103
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0156 0.4244 0.4152
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0038 0.0551 0.0934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0072 0.1623 0.3032
Echinococcus granulosus dro:myosuppressin receptor 0.0072 0.1623 0.3032
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0025 0.0157 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0156 0.4244 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0191 0.5354 0.5354
Echinococcus granulosus g protein coupled receptor 0.0072 0.1623 0.3032
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0025 0.0157 0.0371
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0156 0.4244 1
Echinococcus multilocularis allatostatin A receptor 0.0072 0.1623 0.3032
Leishmania major cathepsin L-like protease 0.0077 0.1779 0.1779
Treponema pallidum catabolite gene activator (Crp) 0.0025 0.0157 0.5
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0025 0.0157 0.0267
Onchocerca volvulus 0.0072 0.1623 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0156 0.4244 0.4152
Trypanosoma cruzi cytochrome P450, putative 0.034 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0038 0.0551 0.103
Echinococcus multilocularis orexin receptor type 2 0.0072 0.1623 0.3032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.1623 0.2749
Schistosoma mansoni neuropeptide receptor 0.0072 0.1623 0.2749
Echinococcus granulosus cGMP dependent protein kinase 1 0.0025 0.0157 0.0294
Echinococcus granulosus hypothetical protein 0.0072 0.1623 0.3032
Echinococcus granulosus orexin receptor type 2 0.0072 0.1623 0.3032
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Leishmania major cyclic nucleotide-binding protein-like protein 0.0025 0.0157 0.0157
Brugia malayi Cyclic-nucleotide gated cation channel 0.0038 0.0551 0.0551
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0156 0.4244 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0156 0.4244 0.4152
Echinococcus granulosus serotonin receptor 0.0072 0.1623 0.3032
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0156 0.4244 0.4152
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Leishmania major cathepsin L-like protease 0.0077 0.1779 0.1779
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0025 0.0157 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0156 0.4244 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0025 0.0157 0.0157
Echinococcus granulosus peptide allatostatin:somatostatin 0.0072 0.1623 0.3032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.1623 0.1623
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0156 0.4244 0.4152
Echinococcus granulosus sex peptide receptor 0.0072 0.1623 0.3032
Schistosoma mansoni hypothetical protein 0.0025 0.0157 0.0267
Echinococcus granulosus g-protein coupled receptor 0.0072 0.1623 0.3032
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0156 0.4244 1
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus 7tm_1 domain containing protein 0.0072 0.1623 0.3032
Loa Loa (eye worm) melatonin receptor type 1A 0.0072 0.1623 0.1623
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0072 0.1623 0.1623
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0072 0.1623 0.1623
Leishmania major hypothetical protein, conserved 0.0025 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0072 0.1623 0.2749
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0025 0.0157 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Onchocerca volvulus 0.0072 0.1623 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.0157 0.0294
Echinococcus granulosus neuropeptide receptor 0.0072 0.1623 0.3032
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0025 0.0157 0.0371
Echinococcus granulosus allatostatin A receptor 0.0072 0.1623 0.3032
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0025 0.0157 0.0267
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0025 0.0157 0.0294
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Onchocerca volvulus 0.0072 0.1623 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0156 0.4244 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0156 0.4244 0.4152
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0025 0.0157 0.0371
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.1623 0.3032
Schistosoma mansoni hypothetical protein 0.0156 0.4244 0.7189
Onchocerca volvulus 0.0072 0.1623 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.1101 0.2057
Entamoeba histolytica cysteine protease, putative 0.002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0025 0.0157 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0156 0.4244 0.4152
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Schistosoma mansoni 60S ribosomal protein L21 0.003 0.0311 0.0526
Echinococcus multilocularis g-protein coupled receptor 0.0072 0.1623 0.3032
Leishmania major cytochrome p450-like protein 0.0156 0.4244 0.4244
Brugia malayi Serotonin receptor 0.0072 0.1623 0.1623
Trypanosoma cruzi protein kinase A regulatory subunit 0.0025 0.0157 0.0157
Leishmania major protein kinase, putative 0.0025 0.0157 0.0157
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0038 0.0551 0.103
Echinococcus granulosus hyperpolarization activated cyclic 0.0038 0.0551 0.103
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.1101 0.1865
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0179 0.496 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0179 0.496 1
Echinococcus multilocularis G protein coupled receptor 139 0.0072 0.1623 0.3032
Echinococcus multilocularis neuropeptide FF receptor 2 0.0072 0.1623 0.3032
Onchocerca volvulus 0.0072 0.1623 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1779 0.1779
Brugia malayi GnHR receptor homolog 0.0072 0.1623 0.1623
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1779 0.1779
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0157 0.0317
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0025 0.0157 0.0267
Trypanosoma cruzi cytochrome P450, putative 0.034 1 1
Echinococcus multilocularis serotonin receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0025 0.0157 0.0294
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0072 0.1623 0.3032
Schistosoma mansoni biogenic amine receptor 0.0072 0.1623 0.2749
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0072 0.1623 0.2749
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0025 0.0157 0.0294
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0191 0.5354 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium leprae Conserved hypothetical protein 0.0156 0.4244 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi Cytochrome P450 family protein 0.0156 0.4244 0.4244
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0311 0.0526
Brugia malayi follicle stimulating hormone receptor 0.0072 0.1623 0.1623
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis 0.0156 0.4244 0.7927
Echinococcus multilocularis somatostatin receptor 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0156 0.4244 0.4152
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0157 0.0267
Echinococcus multilocularis sex peptide receptor 0.0072 0.1623 0.3032
Leishmania major hypothetical protein, conserved 0.0025 0.0157 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0157 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0156 0.4244 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0072 0.1623 0.2749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0025 0.0157 0.097
Echinococcus multilocularis hyperpolarization activated cyclic 0.0038 0.0551 0.103
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0038 0.0551 0.103
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.1623 0.2749
Echinococcus multilocularis g protein coupled receptor 0.0072 0.1623 0.3032
Echinococcus granulosus G protein coupled receptor 139 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0156 0.4244 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0156 0.4244 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0025 0.0157 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0156 0.4244 1
Schistosoma mansoni biogenic amine receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Onchocerca volvulus 0.0072 0.1623 1
Onchocerca volvulus 0.0072 0.1623 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0156 0.4244 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0191 0.5354 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Leishmania major cytochrome p450-like protein 0.034 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0156 0.4244 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0072 0.1623 0.3032
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.1101 0.1865
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0072 0.1623 0.3032
Schistosoma mansoni histamine h1 receptor 0.0072 0.1623 0.2749
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0025 0.0157 1
Schistosoma mansoni cytochrome P450 0.0156 0.4244 0.7189
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0156 0.4244 0.4152
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0157 0.0317
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.1623 0.1623
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0038 0.0551 0.0551
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0551 0.1112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Schistosoma mansoni voltage-gated potassium channel 0.0209 0.5904 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0025 0.0157 0.0267
Echinococcus granulosus neuropeptide receptor 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0156 0.4244 0.4152
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0025 0.0157 0.0294
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi larval opioid receptor 0.0072 0.1623 0.1623
Echinococcus granulosus cGMP dependent protein kinase 0.0025 0.0157 0.0294
Leishmania major regulatory subunit of protein kinase a-like protein 0.0025 0.0157 0.0157
Treponema pallidum cyclic nucleotide binding protein 0.0025 0.0157 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.0157 0.0157
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0072 0.1623 0.2749
Echinococcus granulosus cytochrome P450 2K1 0.0156 0.4244 0.7927
Schistosoma mansoni alpha-1 adrenergic receptor 0.0072 0.1623 0.2749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0025 0.0157 0.0294
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0072 0.1623 0.3032
Brugia malayi G protein-coupled receptor F59B2.13 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Plasmodium falciparum cGMP-dependent protein kinase 0.0025 0.0157 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0072 0.1623 0.2749
Brugia malayi neuropeptide F receptor 0.0072 0.1623 0.1623
Schistosoma mansoni opsin-like receptor 0.0072 0.1623 0.2749
Leishmania major protein kinase, putative 0.0025 0.0157 0.0157
Echinococcus granulosus patatin phospholipase domain containing protein 0.0025 0.0157 0.0294
Schistosoma mansoni neuropeptide receptor 0.0072 0.1623 0.2749
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0072 0.1623 0.3032
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.1623 0.3032
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0025 0.0157 0.5
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.1623 0.3032
Entamoeba histolytica cysteine proteinase, putative 0.002 0 0.5
Leishmania major hypothetical protein, unknown function 0.0025 0.0157 0.0157
Onchocerca volvulus 0.0025 0.0157 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Entamoeba histolytica cysteine proteinase, putative 0.002 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis neuropeptide receptor 0.0072 0.1623 0.3032
Trypanosoma cruzi cAMP response protein 1 0.0025 0.0157 0.0157
Echinococcus granulosus neuropeptide receptor A26 0.0072 0.1623 0.3032
Brugia malayi ORL1-like opioid receptor 0.0072 0.1623 0.1623
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0551 0.0934
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0038 0.0551 0.103
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0157 0.0267
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus neuropeptide s receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0038 0.0551 0.103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0551 0.1112
Echinococcus multilocularis g protein coupled receptor 0.0072 0.1623 0.3032
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0156 0.4244 0.4244
Echinococcus granulosus fmrfamide receptor 0.0072 0.1623 0.3032
Schistosoma mansoni hypothetical protein 0.0072 0.1623 0.2749
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0025 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis fmrfamide receptor 0.0072 0.1623 0.3032
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0157 0.0317
Brugia malayi RE15519p 0.0072 0.1623 0.1623
Echinococcus multilocularis G-protein coupled receptor, putative 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus tachykinin peptides receptor 99D 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.1623 0.3032
Loa Loa (eye worm) hypothetical protein 0.0055 0.1101 0.1101
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0025 0.0157 0.0267
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0191 0.5354 0.5354
Onchocerca volvulus 0.0072 0.1623 1
Schistosoma mansoni opsin-like receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0072 0.1623 0.1623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0072 0.1623 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0156 0.4244 1
Trypanosoma cruzi cAMP binding protein, putative 0.0025 0.0157 0.0157
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.1623 0.3032
Brugia malayi Dopamine receptor 0.0072 0.1623 0.1623
Schistosoma mansoni adenoreceptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0025 0.0157 0.0157
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0025 0.0157 0.0157
Schistosoma mansoni amine GPCR 0.0072 0.1623 0.2749
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0025 0.0157 0.0371
Echinococcus multilocularis serotonin receptor 0.0072 0.1623 0.3032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.1623 0.3032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Schistosoma mansoni neuropeptide receptor 0.0072 0.1623 0.2749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0156 0.4244 1
Trypanosoma brucei cytochrome P450, putative 0.034 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0072 0.1623 0.1623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.1623 0.2749
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0038 0.0551 0.0551
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.1623 0.2749
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0025 0.0157 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0157 0.0267
Trypanosoma cruzi Flagellar Member 6 0.0025 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Echinococcus multilocularis neuropeptide receptor A26 0.0072 0.1623 0.3032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.1623 0.2749
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.1623 0.3032
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0038 0.0551 0.103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0072 0.1623 0.3032
Loa Loa (eye worm) cytochrome P450 family protein 0.034 1 1
Onchocerca volvulus 0.0072 0.1623 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.1623 0.3032
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0072 0.1623 0.2749
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.1623 0.2749
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0072 0.1623 0.3032
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0156 0.4244 0.4152
Brugia malayi G protein-coupled receptor 0.0072 0.1623 0.1623
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1263 0.1263
Schistosoma mansoni hypothetical protein 0.0072 0.1623 0.2749
Brugia malayi N-terminal motif family protein 0.0025 0.0157 0.0157
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.034 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.1623 0.1623
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0025 0.0157 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0072 0.1623 0.1623
Brugia malayi Cytochrome P450 family protein 0.0156 0.4244 0.4244
Brugia malayi hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi G-protein coupled receptor 0.0072 0.1623 0.1623
Schistosoma mansoni hypothetical protein 0.0072 0.1623 0.2749
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0072 0.1623 0.1623
Echinococcus multilocularis expressed conserved protein 0.0025 0.0157 0.0294
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0025 0.0157 0.0294
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0156 0.4244 0.4152
Brugia malayi putative neuropeptide receptor 0.0072 0.1623 0.1623
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.1623 0.2749
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0156 0.4244 0.4152
Schistosoma mansoni voltage-gated potassium channel 0.0209 0.5904 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0156 0.4244 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0072 0.1623 0.2749
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.1623 0.3032
Brugia malayi sulfakinin receptor protein 0.0072 0.1623 0.1623
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.1623 0.2749
Mycobacterium leprae putative cytochrome p450 0.0156 0.4244 1
Treponema pallidum cyclic nucleotide binding protein 0.0025 0.0157 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0072 0.1623 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Brugia malayi Cytochrome P450 family protein 0.034 1 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0025 0.0157 0.0371
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.1623 0.1623
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0156 0.4244 0.4152
Echinococcus multilocularis hyperpolarization activated cyclic 0.0038 0.0551 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1779 0.1648
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0072 0.1623 0.2749
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0551 0.0551
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0156 0.4244 0.4244
Brugia malayi G-protein coupled receptor 0.0072 0.1623 0.1623
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0025 0.0157 0.0267
Trypanosoma cruzi cAMP response protein 1, putative 0.0025 0.0157 0.0157
Brugia malayi putative neuropeptide receptor NPR1 0.0072 0.1623 0.1623
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0156 0.4244 0.4244
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0072 0.1623 0.3032
Brugia malayi cytochrome P450 0.0156 0.4244 0.4244
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0156 0.4244 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0072 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.1623 0.1623

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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