Detailed information for compound 1265960

Basic information

Technical information
  • TDR Targets ID: 1265960
  • Name: 3-(4-chloro-2,5-dimethoxyphenyl)-1-(2,2,6,6-t etramethylpiperidin-4-yl)thiourea
  • MW: 385.952 | Formula: C18H28ClN3O2S
  • H donors: 2 H acceptors: 0 LogP: 3.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(Cl)c(cc1N=C(NC1CC(C)(C)NC(C1)(C)C)S)OC
  • InChi: 1S/C18H28ClN3O2S/c1-17(2)9-11(10-18(3,4)22-17)20-16(25)21-13-8-14(23-5)12(19)7-15(13)24-6/h7-8,11,22H,9-10H2,1-6H3,(H2,20,21,25)
  • InChiKey: AMHGDLONYBMGAD-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(4-chloro-2,5-dimethoxy-phenyl)-1-(2,2,6,6-tetramethyl-4-piperidyl)thiourea
  • 3-(4-chloro-2,5-dimethoxyphenyl)-1-(2,2,6,6-tetramethyl-4-piperidinyl)thiourea
  • 3-(4-chloro-2,5-dimethoxy-phenyl)-1-(2,2,6,6-tetramethylpiperidin-4-yl)thiourea
  • STK143583
  • MLS000662548
  • N-(4-chloro-2,5-dimethoxyphenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)thiourea
  • SMR000292437

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni neuropeptide receptor 0.0055 0.0585 0.109
Schistosoma mansoni opsin-like receptor 0.0055 0.0585 0.109
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0585 0.1231
Schistosoma mansoni histamine h1 receptor 0.0055 0.0585 0.109
Brugia malayi GnHR receptor homolog 0.0055 0.0585 0.0585
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0585 0.0585
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0585 0.1231
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0585 0.1231
Brugia malayi larval opioid receptor 0.0055 0.0585 0.0585
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0585 0.1231
Echinococcus granulosus g protein coupled receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0585 0.1231
Brugia malayi ORL1-like opioid receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0585 0.1231
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Trypanosoma cruzi cytochrome P450, putative 0.0259 1 1
Echinococcus granulosus allatostatin A receptor 0.0055 0.0585 0.1231
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0118 0.3485 0.5
Brugia malayi AKH receptor 0.0055 0.0585 0.0585
Onchocerca volvulus 0.0055 0.0585 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0585 0.1231
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0585 0.109
Schistosoma mansoni hypothetical protein 0.0055 0.0585 0.109
Brugia malayi G-protein coupled receptor 0.0055 0.0585 0.0585
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0585 0.109
Brugia malayi Dopamine receptor protein 1 0.0055 0.0585 0.0585
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0585 0.1231
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Loa Loa (eye worm) CYP4Cod1 0.0259 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0585 0.109
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0118 0.3485 0.5
Schistosoma mansoni hypothetical protein 0.0118 0.3485 0.6496
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0118 0.3485 0.5
Schistosoma mansoni biogenic amine receptor 0.0055 0.0585 0.109
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.3867 0.3867
Echinococcus multilocularis sex peptide receptor 0.0055 0.0585 0.1231
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi Dopamine receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0118 0.3485 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni opsin-like receptor 0.0055 0.0585 0.109
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0585 0.1231
Echinococcus granulosus g protein coupled receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Onchocerca volvulus 0.0055 0.0585 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0118 0.3485 0.5
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0585 0.1231
Schistosoma mansoni opsin-like receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Onchocerca volvulus 0.0055 0.0585 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0585 0.1231
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus neuropeptide receptor 0.0055 0.0585 0.1231
Brugia malayi cytochrome P450 0.0118 0.3485 0.3485
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus orexin receptor type 2 0.0055 0.0585 0.1231
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0118 0.3485 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0259 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0118 0.3485 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0585 0.1231
Brugia malayi Cytochrome P450 family protein 0.0118 0.3485 0.3485
Brugia malayi Melatonin receptor type 1A 0.0055 0.0585 0.0585
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0585 0.0585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0118 0.3485 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0585 0.0585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0585 0.0585
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0141 0.4578 0.4578
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0585 0.109
Schistosoma mansoni biogenic amine receptor 0.0055 0.0585 0.109
Brugia malayi Serotonin receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0585 0.1231
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0585 0.0585
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0585 0.109
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0585 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0118 0.3485 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0145 0.475 0.475
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0585 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Echinococcus multilocularis 0.0118 0.3485 0.7336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0118 0.3485 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis serotonin receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0118 0.3485 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0585 0.1231
Schistosoma mansoni neuropeptide receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni neuropeptide receptor 0.0055 0.0585 0.109
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.431 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0585 0.0585
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.431 0.5
Schistosoma mansoni amine GPCR 0.0055 0.0585 0.109
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0585 0.0585
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0585 0.109
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0118 0.3485 0.5
Onchocerca volvulus 0.0055 0.0585 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0836 0.0836
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0585 0.1231
Schistosoma mansoni amine GPCR 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Schistosoma mansoni neuropeptide receptor 0.0055 0.0585 0.109
Onchocerca volvulus 0.0055 0.0585 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium leprae putative cytochrome p450 0.0118 0.3485 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0585 0.1231
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) cytochrome P450 family protein 0.0118 0.3485 0.3485
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0585 0.1231
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0585 0.1231
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0585 0.1231
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0259 1 1
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0585 0.1231
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0145 0.475 1
Brugia malayi Serotonin receptor 0.0055 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0055 0.0585 0.109
Onchocerca volvulus 0.0055 0.0585 0.5
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi sulfakinin receptor protein 0.0055 0.0585 0.0585
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0585 0.1231
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0118 0.3485 0.5
Onchocerca volvulus 0.0055 0.0585 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0585 0.1231
Brugia malayi RE15519p 0.0055 0.0585 0.0585
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0145 0.475 0.475
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0585 0.0585
Loa Loa (eye worm) cytochrome P450 family protein 0.0259 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0585 0.1231
Echinococcus granulosus cytochrome P450 2K1 0.0118 0.3485 0.7336
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0118 0.3485 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0585 0.109
Echinococcus multilocularis somatostatin receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0585 0.1231
Echinococcus granulosus sex peptide receptor 0.0055 0.0585 0.1231
Echinococcus granulosus hypothetical protein 0.0055 0.0585 0.1231
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0585 0.1231
Echinococcus granulosus serotonin receptor 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0585 0.1231
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0585 0.1231
Schistosoma mansoni adenoreceptor 0.0055 0.0585 0.109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0585 0.5
Schistosoma mansoni amine GPCR 0.0055 0.0585 0.109
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0585 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0585 0.109
Brugia malayi G protein-coupled receptor 0.0055 0.0585 0.0585
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0585 0.0585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Echinococcus granulosus fmrfamide receptor 0.0055 0.0585 0.1231
Schistosoma mansoni voltage-gated potassium channel 0.0158 0.5365 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Brugia malayi putative neuropeptide receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0118 0.3485 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0836 0.0836
Toxoplasma gondii cytochrome p450 superfamily protein 0.0118 0.3485 0.5
Schistosoma mansoni biogenic amine receptor 0.0055 0.0585 0.109
Onchocerca volvulus 0.0055 0.0585 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0585 0.109
Echinococcus granulosus somatostatin receptor 0.0055 0.0585 0.1231
Onchocerca volvulus 0.0055 0.0585 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0118 0.3485 0.5
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0585 0.0585
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) cytochrome P450 family protein 0.0259 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi Dopamine receptor protein 2 0.0055 0.0585 0.0585
Echinococcus granulosus neuropeptide receptor 0.0055 0.0585 0.1231
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0585 0.109
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0585 0.1231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0585 0.109
Echinococcus multilocularis serotonin receptor 0.0055 0.0585 0.1231
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0585 0.1231
Brugia malayi G-protein coupled receptor 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi neuropeptide F receptor 0.0055 0.0585 0.0585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0585 0.109
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0585 0.1231
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0585 0.1231
Schistosoma mansoni myosin xvIII 0.0055 0.0585 0.109
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0585 0.0585
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0118 0.3485 0.5
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Schistosoma mansoni amine GPCR 0.0055 0.0585 0.109
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0585 0.0585
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0145 0.475 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0585 0.1231
Schistosoma mansoni amine GPCR 0.0055 0.0585 0.109
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0585 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0585 0.0585
Echinococcus granulosus g protein coupled receptor 0.0055 0.0585 0.1231
Schistosoma mansoni cytochrome P450 0.0118 0.3485 0.6496
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0118 0.3485 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Trypanosoma brucei cytochrome P450, putative 0.0259 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0118 0.3485 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0585 0.1231
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0585 0.1231
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0585 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0585 0.0585
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0118 0.3485 0.5
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0585 0.1231
Loa Loa (eye worm) cytochrome P450 0.0118 0.3485 0.3485
Brugia malayi Cytochrome P450 family protein 0.0259 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0585 0.109
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0585 0.1231
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0585 0.0585
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0585 0.1231
Brugia malayi Cytochrome P450 family protein 0.0118 0.3485 0.3485
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0585 0.1231
Leishmania major cytochrome p450-like protein 0.0259 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0585 0.109
Brugia malayi hypothetical protein 0.0055 0.0585 0.0585
Brugia malayi neuropeptide F receptor 0.0055 0.0585 0.0585
Schistosoma mansoni voltage-gated potassium channel 0.0158 0.5365 1
Onchocerca volvulus 0.0055 0.0585 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0836 0.0836
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0585 0.109
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0118 0.3485 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0585 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0585 0.1231
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0836 0.0836
Schistosoma mansoni hypothetical protein 0.0055 0.0585 0.109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0585 0.109

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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