Detailed information for compound 1265982

Basic information

Technical information
  • TDR Targets ID: 1265982
  • Name: 1-[2-(2-ethoxyphenoxy)ethoxy]-2-propan-2-ylox ybenzene
  • MW: 316.391 | Formula: C19H24O4
  • H donors: 0 H acceptors: 0 LogP: 4.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1OCCOc1ccccc1OC(C)C
  • InChi: 1S/C19H24O4/c1-4-20-16-9-5-6-10-17(16)21-13-14-22-18-11-7-8-12-19(18)23-15(2)3/h5-12,15H,4,13-14H2,1-3H3
  • InChiKey: NCKZVQLIUXCUQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(2-ethoxyphenoxy)ethoxy]-2-isopropoxy-benzene
  • 1-[2-(2-ethoxyphenoxy)ethoxy]-2-isopropoxybenzene
  • 1-[2-(2-ethoxyphenoxy)ethoxy]-2-propan-2-yloxy-benzene
  • 6483-41-6
  • ZINC02991012
  • 1-ethoxy-2-[2-(2-isopropoxyphenoxy)ethoxy]benzene
  • SMR000141438
  • MLS000534002

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ADAM-TS Spacer 1 family protein 0.0073 0.0128 0.017
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Brugia malayi TATA binding protein associated factor 0.0195 0.0629 0.0835
Trypanosoma cruzi Aminopeptidase M1, putative 0.0556 0.2098 0.564
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0067 0.0107 0.013
Echinococcus granulosus cubilin 0.0069 0.0112 0.0136
Echinococcus granulosus cathepsin b 0.0056 0.0058 0.0065
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0069 0.0112 0.0148
Toxoplasma gondii aminopeptidase N protein 0.0195 0.0629 0.062
Echinococcus multilocularis adam 0.0124 0.0337 0.0435
Echinococcus multilocularis aminopeptidase N 0.1889 0.7529 1
Schistosoma mansoni glycogen phosphorylase 0.0049 0.0033 0.0106
Loa Loa (eye worm) matrixin family protein 0.0738 0.284 0.4219
Brugia malayi Trypsin family protein 0.0101 0.0242 0.0321
Onchocerca volvulus Matrix metalloproteinase homolog 0.0647 0.2469 0.3271
Echinococcus granulosus histone deacetylase 3 0.0065 0.0096 0.0114
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0151 0.0448 0.0665
Onchocerca volvulus 0.0089 0.0196 0.0248
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0195 0.0629 0.0824
Schistosoma mansoni hypothetical protein 0.0372 0.1347 0.4307
Onchocerca volvulus Putative cubilin 0.0095 0.0219 0.0278
Loa Loa (eye worm) hypothetical protein 0.0329 0.1175 0.1745
Brugia malayi CUB domain containing protein 0.0069 0.0112 0.0148
Trypanosoma cruzi aminopeptidase, putative 0.0556 0.2098 0.564
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0318 0.1126 0.1485
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0101 0.0246 0.0365
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0151 0.0448 0.1184
Brugia malayi Matrixin family protein 0.0292 0.1021 0.1356
Loa Loa (eye worm) TATA binding protein associated factor 0.0195 0.0629 0.0934
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0556 0.2098 0.2777
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0151 0.0448 0.2009
Loa Loa (eye worm) hypothetical protein 0.0065 0.0096 0.0142
Giardia lamblia Histone deacetylase 0.0065 0.0096 0.1853
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0151 0.0448 0.0583
Loa Loa (eye worm) beta-lactamase 0.0043 0.0009 0.0014
Echinococcus granulosus glycogen phosphorylase 0.0114 0.0297 0.0382
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Brugia malayi Nematode astacin protease protein 30 0.0101 0.0246 0.0326
Loa Loa (eye worm) hypothetical protein 0.0195 0.0629 0.0934
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0355 0.128 0.1272
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0069 0.0112 0.0357
Echinococcus granulosus Tolloid protein 1 0.0809 0.3128 0.4147
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0195 0.0629 0.0824
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0069 0.0112 0.0276
Echinococcus multilocularis histone deacetylase 3 0.0065 0.0096 0.0114
Plasmodium falciparum histone deacetylase 1 0.0065 0.0096 0.0046
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0195 0.0629 0.1673
Echinococcus multilocularis histone deacetylase 1 0.0065 0.0096 0.0114
Brugia malayi angiogenesis inhibito 0.0073 0.0128 0.017
Toxoplasma gondii aminopeptidase N, putative 0.0195 0.0629 0.062
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0556 0.2098 0.564
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0438 0.1616 0.5166
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0556 0.2098 0.564
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0101 0.0246 0.0326
Onchocerca volvulus 0.0069 0.0112 0.0136
Brugia malayi cathepsin B-like cysteine proteinase 0.0056 0.0058 0.0078
Mycobacterium leprae PROBABLE HYDROLASE 0.0355 0.128 0.1272
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.0705 0.0937
Loa Loa (eye worm) hypothetical protein 0.0712 0.2732 0.4059
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0069 0.0112 0.0357
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0151 0.0448 0.1432
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0195 0.0629 0.1673
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0098 0.023 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0163 0.0735
Onchocerca volvulus 0.0069 0.0112 0.0136
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0368 0.1334 0.4264
Echinococcus granulosus snurportin 1 0.0372 0.1347 0.1779
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0235 0.0788 0.1047
Mycobacterium ulcerans peptide deformylase 0.2495 1 1
Onchocerca volvulus Matrilysin homolog 0.0724 0.2781 0.3686
Giardia lamblia Cathepsin B precursor 0.0081 0.0163 0.458
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0067 0.0107 0.0343
Leishmania major histone deacetylase, putative 0.0065 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0151 0.0448 0.0439
Brugia malayi CUB domain containing protein 0.0069 0.0112 0.0148
Trichomonas vaginalis glycogen phosphorylase, putative 0.0114 0.0297 0.1376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0058 0.0187
Trypanosoma cruzi Peptide deformylase 2, putative 0.0952 0.3712 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0242 0.0359
Loa Loa (eye worm) hypothetical protein 0.0101 0.0242 0.0359
Toxoplasma gondii preprocathepsin c precursor, putative 0.0053 0.005 0.004
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0053 0.005 0.004
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1094 0.4288 0.569
Schistosoma mansoni gamma-secretase subunit aph-1 0.0098 0.023 0.0736
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0195 0.0629 0.0934
Loa Loa (eye worm) CUB domain-containing protein 0.0069 0.0112 0.0166
Loa Loa (eye worm) hypothetical protein 0.0101 0.0246 0.0365
Brugia malayi Matrixin family protein 0.0292 0.1021 0.1356
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Loa Loa (eye worm) hypothetical protein 0.0368 0.1334 0.1981
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0009 0.0013
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0151 0.0448 0.0595
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0009 0.0014
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.2495 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Onchocerca volvulus Glycogen phosphorylase homolog 0.0114 0.0297 0.0382
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0151 0.0448 0.2099
Loa Loa (eye worm) DPY-31 protein 0.0101 0.0246 0.0365
Schistosoma mansoni glycogen phosphorylase 0.0114 0.0297 0.0949
Onchocerca volvulus Matrilysin homolog 0.0292 0.1021 0.1345
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0261 0.0895 0.133
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.0163 0.0216
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0078 0.0103
Loa Loa (eye worm) hypothetical protein 0.0095 0.0219 0.0325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Echinococcus multilocularis glycogen phosphorylase 0.0114 0.0297 0.0382
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0069 0.0112 0.0166
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Loa Loa (eye worm) AStacin protease 0.0506 0.1893 0.2811
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0087
Echinococcus granulosus adam 0.0124 0.0337 0.0435
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0357
Plasmodium vivax histone deacetylase 1, putative 0.0065 0.0096 0.0086
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0151 0.0448 0.2099
Loa Loa (eye worm) hypothetical protein 0.0056 0.0062 0.0091
Brugia malayi hypothetical protein 0.0195 0.0629 0.0835
Onchocerca volvulus 0.037 0.1339 0.1768
Trypanosoma brucei histone deacetylase 1 0.0065 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0073 0.0128 0.019
Brugia malayi Fibulin-1 precursor 0.0261 0.0895 0.1189
Brugia malayi Nematode astacin protease protein 30 0.0101 0.0246 0.0326
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0809 0.3128 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.1021 0.1517
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0069 0.0112 0.0276
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0357
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0151 0.0448 0.1184
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0952 0.3712 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0355 0.128 0.17
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.2495 1 0.5
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0049 0.0033 0.0024
Trypanosoma brucei Aminopeptidase M1, putative 0.0556 0.2098 0.564
Brugia malayi Matrixin family protein 0.0292 0.1021 0.1356
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0191 0.0609 0.1948
Onchocerca volvulus 0.0292 0.1021 0.1345
Leishmania major histone deacetylase, putative 0.0065 0.0096 0.0232
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.0242 0.0773
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Loa Loa (eye worm) hypothetical protein 0.1333 0.5263 0.7818
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.2495 1 1
Trypanosoma brucei Peptide deformylase 2 0.0952 0.3712 1
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Echinococcus granulosus gamma secretase subunit aph 1 0.0098 0.023 0.0294
Echinococcus multilocularis cubilin 0.0069 0.0112 0.0136
Echinococcus multilocularis gamma secretase subunit aph 1 0.0098 0.023 0.0294
Loa Loa (eye worm) matrix metalloproteinase 0.0292 0.1021 0.1517
Echinococcus multilocularis cathepsin b 0.0056 0.0058 0.0065
Brugia malayi hypothetical protein 0.0069 0.0112 0.0148
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0556 0.2098 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0629 0.0934
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0069 0.0112 0.0166
Trichomonas vaginalis glycogen phosphorylase, putative 0.0114 0.0297 0.1376
Toxoplasma gondii aminopeptidase n, putative 0.0195 0.0629 0.062
Loa Loa (eye worm) disintegrin family protein 0.0065 0.0099 0.0147
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0207 0.0675 0.0884
Brugia malayi Hemopexin family protein 0.037 0.1339 0.1779
Echinococcus multilocularis cathepsin b 0.0056 0.0058 0.0065
Echinococcus granulosus cathepsin b 0.0056 0.0058 0.0065
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0361 0.1301 0.3489
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1094 0.4288 0.569
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Echinococcus multilocularis cubilin 0.0069 0.0112 0.0136
Brugia malayi CUB domain containing protein 0.0069 0.0112 0.0148
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1347 0.2001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0058 0.0187
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0067 0.0107 0.013
Loa Loa (eye worm) hypothetical protein 0.0235 0.0788 0.117
Brugia malayi ADAMTS-like protease 0.0073 0.0128 0.017
Brugia malayi Disintegrin family protein 0.0117 0.0307 0.0408
Echinococcus multilocularis laminin 0.0261 0.0895 0.1178
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Brugia malayi Calcium binding EGF domain containing protein 0.0261 0.0895 0.1189
Mycobacterium ulcerans hydrolase 0.0355 0.128 0.1272
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0361 0.1301 0.4161
Trypanosoma cruzi histone deacetylase 1, putative 0.0065 0.0096 0.0232
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0556 0.2098 0.564
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0096 0.0412
Schistosoma mansoni egf-like domain protein 0.0235 0.0788 0.2519
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Trypanosoma cruzi aminopeptidase, putative 0.0195 0.0629 0.1673
Onchocerca volvulus 0.1889 0.7529 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.0163 0.0216
Echinococcus granulosus adam 17 protease 0.0489 0.1824 0.2414
Entamoeba histolytica histone deacetylase, putative 0.0065 0.0096 0.0302
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0069 0.0112 0.0136
Loa Loa (eye worm) hypothetical protein 0.0292 0.1021 0.1517
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0195 0.0629 0.0824
Loa Loa (eye worm) hypothetical protein 0.0261 0.0895 0.133
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0056 0.0058 0.0132
Echinococcus multilocularis fibrillin 1 0.0261 0.0895 0.1178
Loa Loa (eye worm) hypothetical protein 0.0355 0.128 0.1902
Brugia malayi Matrixin family protein 0.0292 0.1021 0.1356
Plasmodium falciparum peptide deformylase 0.2495 1 1
Echinococcus multilocularis adam 17 protease 0.0438 0.1616 0.2136
Loa Loa (eye worm) hypothetical protein 0.0235 0.0788 0.117
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Treponema pallidum polypeptide deformylase (def) 0.2495 1 0.5
Schistosoma mansoni glycogen phosphorylase 0.0114 0.0297 0.0949
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0078 0.0103
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0357
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0195 0.0629 0.2011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.0163 0.0735
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0361 0.1301 0.1718
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0112 0.049
Onchocerca volvulus 0.0556 0.2098 0.2777
Brugia malayi CUB domain containing protein 0.0069 0.0112 0.0148
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0195 0.0629 0.062
Giardia lamblia Glycogen phosphorylase 0.0114 0.0297 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0163 0.0735
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0195 0.0629 0.2966
Trypanosoma brucei aminopeptidase, putative 0.0195 0.0629 0.1673
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0195 0.0629 0.0582
Loa Loa (eye worm) matrixin family protein 0.0647 0.2469 0.3667
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0556 0.2098 0.564
Echinococcus multilocularis disintegrin and metalloproteinase 0.0117 0.0307 0.0396
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0053 0.005 0.0159
Loa Loa (eye worm) reprolysin 0.0067 0.0107 0.0159
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0163 0.0735
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Toxoplasma gondii calcium binding egf domain-containing protein 0.0261 0.0895 0.0886
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0069 0.0112 0.0136
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0096 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0078 0.0115
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0151 0.0448 0.0665
Onchocerca volvulus Arrow homolog 0.0235 0.0788 0.1035
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.0681 0.3216
Loa Loa (eye worm) hypothetical protein 0.0361 0.1301 0.1933
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0318 0.1126 0.1485
Schistosoma mansoni dihydroceramide desaturase 0.0117 0.0307 0.0983
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0096 0.0412
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0207 0.0675 0.0884
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0195 0.0629 0.1673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Brugia malayi Lectin C-type domain containing protein 0.0069 0.0112 0.0148
Leishmania major polypeptide deformylase-like protein, putative 0.0952 0.3712 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0078 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0009 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0964 0.0956
Onchocerca volvulus 0.0101 0.0242 0.0309
Toxoplasma gondii cathepsin CPC1 0.0053 0.005 0.004
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0096 0.0412
Echinococcus multilocularis Tolloid protein 1 0.0809 0.3128 0.4147
Loa Loa (eye worm) hypothetical protein 0.0361 0.1301 0.1933
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0056 0.0058 0.0187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0009 0.003
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0101 0.0246 0.0326
Echinococcus multilocularis snurportin 1 0.0372 0.1347 0.1779
Brugia malayi Matrixin family protein 0.0738 0.284 0.3773
Loa Loa (eye worm) hypothetical protein 0.1693 0.6732 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0235 0.0788 0.117
Echinococcus multilocularis glycogen phosphorylase 0.0114 0.0297 0.0382
Brugia malayi beta-lactamase family protein 0.0043 0.0009 0.0013
Schistosoma mansoni aminopeptidase A (M01 family) 0.0195 0.0629 0.2011
Trypanosoma brucei Polypeptide deformylase 1 0.0952 0.3712 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0195 0.0629 0.2011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0014
Loa Loa (eye worm) CUB domain-containing protein 0.0069 0.0112 0.0166
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0809 0.3128 0.4646
Loa Loa (eye worm) peptidase family M1 containing protein 0.1528 0.606 0.9001
Brugia malayi Kelch motif family protein 0.0069 0.0112 0.0148
Echinococcus granulosus histone deacetylase 1 0.0065 0.0096 0.0114
Toxoplasma gondii calcium binding egf domain-containing protein 0.0261 0.0895 0.0886
Loa Loa (eye worm) histone deacetylase 1 0.0065 0.0096 0.0142
Schistosoma mansoni hypothetical protein 0.037 0.1339 0.4282
Brugia malayi RNA, U transporter 1 0.0099 0.0236 0.0313
Trypanosoma brucei Aminopeptidase M1, putative 0.0556 0.2098 0.564
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0058 0.0187
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0195 0.0629 0.0582
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0069 0.0112 0.0276
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0081 0.0163 0.0242
Loa Loa (eye worm) hypothetical protein 0.0067 0.0107 0.0159
Brugia malayi Peptidase family M1 containing protein 0.0195 0.0629 0.0835
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0556 0.2098 0.6707
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0049 0.0033 0.0024
Echinococcus granulosus disintegrin and metalloproteinase 0.0117 0.0307 0.0396
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0556 0.2098 1
Loa Loa (eye worm) histone deacetylase 3 0.0065 0.0096 0.0142
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0567 0.2144 0.6855
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0195 0.0626 0.1665
Echinococcus granulosus CUB 0.0069 0.0112 0.0136
Brugia malayi CUB domain containing protein 0.0069 0.0112 0.0148
Onchocerca volvulus 0.0101 0.0246 0.0314
Loa Loa (eye worm) hypothetical protein 0.0069 0.0112 0.0166
Echinococcus granulosus glycogen phosphorylase 0.0114 0.0297 0.0382
Brugia malayi carbohydrate phosphorylase 0.0114 0.0297 0.0394
Brugia malayi astacin protease protein 30 0.0101 0.0246 0.0326
Entamoeba histolytica glycogen phosphorylase, putative 0.0114 0.0297 0.1277
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0151 0.0448 0.0595
Brugia malayi beta-lactamase family protein 0.0043 0.0009 0.0013
Brugia malayi Histone deacetylase 1 0.0065 0.0096 0.0127
Trypanosoma cruzi Peptide deformylase 2, putative 0.0952 0.3712 1
Schistosoma mansoni histone deacetylase 0.0065 0.0096 0.0305
Loa Loa (eye worm) hypothetical protein 0.0195 0.0629 0.0934
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.008 0.0158 0.0505
Brugia malayi histone deacetylase 3 (HD3) 0.0065 0.0096 0.0127
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0207 0.0675 0.2157
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0053 0.005 0.004
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0151 0.0448 0.0439
Brugia malayi histone deacetylase 1 (HD1) 0.0065 0.0096 0.0127
Loa Loa (eye worm) hypothetical protein 0.0073 0.0128 0.019
Brugia malayi Peptidase family M1 containing protein 0.1889 0.7529 1
Echinococcus multilocularis CUB 0.0069 0.0112 0.0136
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0067 0.0107 0.0343
Onchocerca volvulus 0.0069 0.0112 0.0136
Toxoplasma gondii histone deacetylase HDAC3 0.0065 0.0096 0.0086
Brugia malayi gamma-secretase subunit aph-1 0.0098 0.023 0.0306
Brugia malayi hypothetical protein 0.0124 0.0337 0.0447
Entamoeba histolytica aminopeptidase, putative 0.0556 0.2098 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0151 0.0448 0.04
Onchocerca volvulus 0.0195 0.0629 0.0824
Brugia malayi hypothetical protein 0.0556 0.2098 0.2786
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0195 0.0629 0.1673
Mycobacterium ulcerans aminopeptidase N PepN 0.0195 0.0629 0.062
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0521 0.1667
Brugia malayi Calcium binding EGF domain containing protein 0.0095 0.0219 0.0291
Echinococcus granulosus cubilin 0.0069 0.0112 0.0136
Entamoeba histolytica glycogen phosphorylase, putative 0.0114 0.0297 0.1277
Echinococcus granulosus leukotriene A 4 hydrolase 0.0195 0.0629 0.0824
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0357
Loa Loa (eye worm) hypothetical protein 0.0776 0.2994 0.4447
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0151 0.0448 0.1184
Toxoplasma gondii hypothetical protein 0.2495 1 1
Schistosoma mansoni histone deacetylase 0.0065 0.0096 0.0305
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0124 0.0337 0.1076
Echinococcus granulosus aminopeptidase N 0.1889 0.7529 1
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0357
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.2098 0.2777
Loa Loa (eye worm) hypothetical protein 0.0214 0.0705 0.1047
Brugia malayi Peptidase family M1 containing protein 0.0556 0.2098 0.2786
Toxoplasma gondii histone deacetylase HDAC2 0.0065 0.0096 0.0086
Echinococcus granulosus laminin 0.0261 0.0895 0.1178
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0952 0.3712 1
Brugia malayi beta-lactamase 0.0043 0.0009 0.0013
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0195 0.0629 0.1673
Trypanosoma cruzi histone deacetylase 1, putative 0.0065 0.0096 0.0232
Plasmodium vivax peptide deformylase, putative 0.2495 1 1
Loa Loa (eye worm) glycogen phosphorylase 0.0114 0.0297 0.0441
Mycobacterium ulcerans aminopeptidase N PepN 0.0556 0.2098 0.209
Loa Loa (eye worm) aminopeptidase N 0.0556 0.2098 0.3116
Echinococcus multilocularis Glycosyl transferase, family 35 0.0114 0.0297 0.0382
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0195 0.0629 0.062
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0151 0.0448 0.1184
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0195 0.0629 0.1673
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0151 0.0448 0.0583
Echinococcus granulosus Glycosyl transferase family 35 0.0114 0.0297 0.0382
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0207 0.0675 0.0896

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 5.52 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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