Detailed information for compound 1266140

Basic information

Technical information
  • TDR Targets ID: 1266140
  • Name: NCGC00101930-01
  • MW: 382.39 | Formula: C19H14N2O5S
  • H donors: 2 H acceptors: 5 LogP: 2.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cccc(c1)NS(=O)(=O)c1ccc2c3c1cccc3c(=O)n2C
  • InChi: 1S/C19H14N2O5S/c1-21-15-8-9-16(13-6-3-7-14(17(13)15)18(21)22)27(25,26)20-12-5-2-4-11(10-12)19(23)24/h2-10,20H,1H3,(H,23,24)
  • InChiKey: KQTYCEJBQKGRKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AQ-390/42869116

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.3096
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0129 0.0104
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0129 0.0104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0074 0.4815
Mycobacterium ulcerans hypothetical protein 0.0029 0.0074 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0315
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0129 0.0056
Loa Loa (eye worm) RNA binding protein 0.0063 0.0201 0.2449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0169
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Toxoplasma gondii ABC1 family protein 0.0043 0.0129 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0026 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0043 0.0017
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.1107
Echinococcus granulosus GPCR family 2 0.0016 0.0026 0.0176
Echinococcus multilocularis GPCR, family 2 0.0016 0.0026 0.0176
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0201 0.3217
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0096 0.6434
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.1393
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.3096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0129 0.1975
Leishmania major cysteinyl-tRNA synthetase, putative 0.0039 0.0114 0.87
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0039 0.0114 1
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0114 0.87
Loa Loa (eye worm) hypothetical protein 0.0049 0.0151 0.1844
Onchocerca volvulus 0.0029 0.0074 0.1151
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.0061
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0039 0.0114 0.8363
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0197
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0074 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0074 0.4815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0043 0.0017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0176
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0101 0.0343 0.5698
Schistosoma mansoni transcription factor btf3 0.0035 0.0096 0.1249
Plasmodium vivax cysteine--tRNA ligase, putative 0.0039 0.0114 0.8538
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0114 0.87
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0093 0.0993
Echinococcus multilocularis lamin dm0 0.0027 0.0067 0.0892
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0096 0.7168
Leishmania major basic transcription factor 3a, putative 0.0035 0.0096 0.7168
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.0061
Brugia malayi beta-NAC-like protein 0.0035 0.0096 0.1033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0074 0.0048
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0039 0.0114 0.1254
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0176
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0129 0.1831
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.2058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0129 0.1578
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.1107
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0039 0.0114 0.87
Mycobacterium leprae Probable lipase LipE 0.0043 0.0129 0.0056
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0039 0.0114 0.1393
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0067 0.0817
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0129 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Trichomonas vaginalis esterase, putative 0.0043 0.0129 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0037 0.0297
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0074 0.0061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0176
Brugia malayi TAR-binding protein 0.0063 0.0201 0.2328
Echinococcus granulosus lamin 0.0027 0.0067 0.0892
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0074 0.0061
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0096 0.7982
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0037 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0201 0.2449
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0067 0.0817
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0013 0.0159
Schistosoma mansoni hypothetical protein 0.0168 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0096 0.6434
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0197
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.0358 0.5954
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0037 0.2058
Treponema pallidum cysteinyl-tRNA synthetase 0.0039 0.0114 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0758
Mycobacterium tuberculosis Conserved protein 0.0043 0.0129 0.0104
Schistosoma mansoni lamin 0.0027 0.0067 0.0728
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0013 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0129 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0047 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Brugia malayi beta-lactamase family protein 0.0043 0.0129 0.1442
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0037 0.037
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0096 0.7168
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0129 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0026 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.1136
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0201 0.2449
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0129 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.5256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0151 0.1712
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0047 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0037 0.2058
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0026 0.0158
Mycobacterium ulcerans lipase LipD 0.0043 0.0129 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.5256
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0795
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0129 0.1831
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0905
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.2058
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0039 0.0114 0.1713
Echinococcus granulosus tar DNA binding protein 0.0063 0.0201 0.3217
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.1107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0176
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0129 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.1107
Echinococcus multilocularis musashi 0.0027 0.0067 0.0892
Mycobacterium tuberculosis Conserved protein 0.0043 0.0129 0.0104
Mycobacterium ulcerans beta-lactamase 0.0043 0.0129 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.107
Echinococcus granulosus cysteinyl tRNA synthetase 0.0039 0.0114 0.1713
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.1107
Echinococcus granulosus transcription factor btf3 0.0035 0.0096 0.1403
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0129 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0129 0.0116
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0129 0.0104
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2702 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0178
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0067 0.0669
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0114 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0074 0.4815
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0098
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0129 0.1975
Echinococcus multilocularis geminin 0.0168 0.0591 1
Giardia lamblia Cysteinyl-tRNA synthetase 0.0039 0.0114 1
Onchocerca volvulus 0.0043 0.0129 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0129 0.0104
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.016
Onchocerca volvulus 0.0039 0.0114 0.7575
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0096 0.7168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0151 0.1712
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.0358 0.5882
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0096 0.6816
Brugia malayi beta-lactamase 0.0043 0.0129 0.1442
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0037 0.037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0129 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.3096
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0114 0.1564
Schistosoma mansoni lamin 0.0027 0.0067 0.0728
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0074 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.5256
Echinococcus multilocularis lamin 0.0027 0.0067 0.0892
Schistosoma mansoni hypothetical protein 0.0034 0.0093 0.1191
Chlamydia trachomatis cysteine--tRNA ligase 0.0039 0.0114 1
Brugia malayi intermediate filament protein 0.0027 0.0067 0.0669
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0037 0.0451
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0047 0.242
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0013 0.0159
Echinococcus granulosus geminin 0.0168 0.0591 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0151 0.1844
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0096 0.6816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0043 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.3096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0576
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0129 0.1442
Brugia malayi beta-lactamase family protein 0.0043 0.0129 0.1442
Onchocerca volvulus 0.0043 0.0129 1
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0039 0.0114 0.8538
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0043 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0229 0.0819 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0074 0.0061
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0316
Schistosoma mansoni intermediate filament proteins 0.0027 0.0067 0.0728
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.3096
Mycobacterium tuberculosis Conserved protein 0.0043 0.0129 0.0104
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0201 0.2328
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0178
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0039 0.0114 0.0101
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.1578
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0576
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0114 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0255
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.1253
Onchocerca volvulus 0.0043 0.0129 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0129 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0129 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0758
Toxoplasma gondii exonuclease III APE 0.0019 0.0037 0.107
Loa Loa (eye worm) beta-lactamase 0.0043 0.0129 0.1578
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0129 1
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2702 1 1
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0114 0.1564
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0039 0.0114 1
Echinococcus multilocularis transcription factor btf3 0.0035 0.0096 0.1403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0037 0.0024
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0096 0.1176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0576
Echinococcus granulosus lamin dm0 0.0027 0.0067 0.0892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0817
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0047 0.2066
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0576
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.7694
Echinococcus granulosus leucyl tRNA synthetase 0.0039 0.0114 0.1713
Echinococcus granulosus intermediate filament protein 0.0027 0.0067 0.0892
Leishmania major hypothetical protein, conserved 0.0043 0.0129 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0178
Brugia malayi RNA binding protein 0.0063 0.0201 0.2328
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0905
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0096 0.7694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0576
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0999 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0096 0.6434
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0758
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0129 0.0104
Schistosoma mansoni hypothetical protein 0.0168 0.0591 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.0819 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0129 0.0116

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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