Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0198 | 0.0198 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0067 | 0.2417 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0115 | 0.5055 | 0.5055 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0198 | 0.0198 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0115 | 0.5055 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0115 | 0.5055 | 0.5055 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3698 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0115 | 0.5055 | 0.5055 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.344 | 0.344 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.3074 | 0.8194 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.3074 | 0.8987 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Echinococcus granulosus | voltage gated potassium channel | 0.0028 | 0.0243 | 0.0243 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2916 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3413 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0243 | 0.0516 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.344 | 0.344 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0356 | 0.0327 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1249 | 0.2912 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0028 | 0.0243 | 0.0243 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1539 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2548 | 0.7412 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0028 | 0.0243 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0071 | 0.0071 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0067 | 0.2417 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0198 | 0.0198 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.3074 | 0.3074 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0028 | 0.0243 | 0.0243 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0028 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1254 | 0.3541 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0028 | 0.0243 | 0.0243 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.3074 | 0.3074 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1412 | 0.4014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.