Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.