Detailed information for compound 1267066

Basic information

Technical information
  • TDR Targets ID: 1267066
  • Name: N-(5-phenyl-1,3,4-oxadiazol-2-yl)-1,3-benzoth iazole-2-carboxamide
  • MW: 322.341 | Formula: C16H10N4O2S
  • H donors: 1 H acceptors: 4 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nc2c(s1)cccc2)Nc1nnc(o1)c1ccccc1
  • InChi: 1S/C16H10N4O2S/c21-13(15-17-11-8-4-5-9-12(11)23-15)18-16-20-19-14(22-16)10-6-2-1-3-7-10/h1-9H,(H,18,20,21)
  • InChiKey: FJTVSMDFNPODDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000103331
  • SMR000018736
  • IDI1_010858
  • MLS000686110
  • ZINC04276171
  • IFLab1_005455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SUMO1 activating enzyme subunit 1 No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens ubiquitin-like modifier activating enzyme 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Neospora caninum hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania donovani ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium vivax ubiquitin activating enzyme, putative Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus granulosus SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium yoelii related to ubiquitin-activating enzyme homolog UBA2-related Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania major ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Babesia bovis conserved hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum AFR138Wp, related Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium knowlesi SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania mexicana ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium hominis SUMO-1 activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K10685 ubiquitin-like 1-activating enzyme E1 B, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium parvum SUMO-1 activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni ubiquitin-activating enzyme E1b Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium berghei SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Babesia bovis ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus sumo-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum SUMO-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis SUMO activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Ubiquitin-activating enzyme E1 1 Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Plasmodium vivax SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium yoelii SUMO-1 activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium falciparum SUMO-activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi ThiF family protein Get druggable targets OG5_128859 All targets in OG5_128859
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania braziliensis ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0213 0.3832 0.3832
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0213 0.3832 0.3832
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0213 0.3832 0.5871
Loa Loa (eye worm) hypothetical protein 0.0361 0.8025 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0213 0.3832 0.3832
Brugia malayi Steroid receptor seven-up type 2 0.0213 0.3832 0.4775
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.011 0.0944 0.1176
Brugia malayi nuclear receptor NHR-88 0.0213 0.3832 0.4775
Brugia malayi nuclear receptor NHR-67 0.0097 0.0566 0.0706
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0116 0.1112 0.1703
Echinococcus granulosus nuclear receptor nhr 48 0.0097 0.0566 0.0868
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.3832 0.9271
Loa Loa (eye worm) hypothetical protein 0.0082 0.0164 0.0204
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Loa Loa (eye worm) steroid hormone receptor 0.0213 0.3832 0.4775
Schistosoma mansoni retinoic acid receptor RXR 0.0308 0.6528 0.6528
Onchocerca volvulus 0.0213 0.3832 0.36
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Brugia malayi Nuclear hormone receptor-like 1 0.0213 0.3832 0.4775
Brugia malayi nuclear receptor RXR 0.0116 0.1112 0.1385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.3832 0.5871
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.3832 0.4775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0213 0.3832 0.4775
Brugia malayi nuclear hormone receptor 0.0303 0.6372 0.794
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0097 0.0566 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0213 0.3832 0.4775
Loa Loa (eye worm) DR-78 0.0097 0.0566 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1236 0.1541
Brugia malayi hypothetical protein 0.0097 0.0566 0.0706
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0306 0.6452 0.804
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0213 0.3832 0.4775
Schistosoma mansoni thyroid hormone receptor 0.0213 0.3832 0.3832
Echinococcus granulosus thyroid hormone receptor alpha 0.0097 0.0566 0.0868
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.1385
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0213 0.3832 0.3832
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.1112 0.1112
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0116 0.1112 0.2689
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.3832 0.9271
Brugia malayi tailless protein 0.0097 0.0566 0.0706
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0213 0.3832 0.9271
Schistosoma mansoni thyroid hormone receptor 0.0213 0.3832 0.3832
Brugia malayi hypothetical protein 0.0116 0.1112 0.1385
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0213 0.3832 0.4775
Echinococcus granulosus FTZ F1 alpha 0.0213 0.3832 0.5871
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.0566 0.137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.0566 0.137
Loa Loa (eye worm) hypothetical protein 0.011 0.0944 0.1176
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.4134 0.6333
Brugia malayi nuclear hormone receptor family member nhr-6 0.0097 0.0566 0.0706
Onchocerca volvulus Bile acid receptor homolog 0.0361 0.8025 0.8222
Schistosoma mansoni nuclear hormone receptor 0.0213 0.3832 0.3832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0213 0.3832 0.4775
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.0566 0.0868
Echinococcus multilocularis thyroid hormone receptor alpha 0.0213 0.3832 0.9271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0213 0.3832 0.4775
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.0566 0.0868
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0213 0.3832 0.9271
Echinococcus multilocularis transcription factor eb 0.0111 0.0959 0.2319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0213 0.3832 0.4775
Echinococcus multilocularis nuclear receptor nhr 48 0.0097 0.0566 0.137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0213 0.3832 0.3832
Loa Loa (eye worm) nuclear hormone receptor 0.0097 0.0566 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.3832 0.4775
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0097 0.0566 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.1385
Brugia malayi nuclear hormone receptor 0.0213 0.3832 0.4775
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0308 0.6528 1
Echinococcus granulosus transcription factor eb 0.0111 0.0959 0.1469
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi nuclear receptor RXR 0.0097 0.0566 0.0706
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0419 0.9638 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0213 0.3832 0.3832
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0213 0.3832 0.5871
Brugia malayi ecdysone receptor 0.0097 0.0566 0.0706
Brugia malayi nuclear receptor NHR-88 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.1385
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0097 0.0566 0.0566
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0213 0.3832 0.5871
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.1112 0.1385
Brugia malayi Nuclear hormone receptor E75 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.1385
Brugia malayi conserved hypotetical protein 0.0097 0.0566 0.0706
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0097 0.0566 0.137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.4134 1
Brugia malayi ecdysteroid receptor 0.0361 0.8025 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0213 0.3832 0.9271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0213 0.3832 0.4775
Schistosoma mansoni coup transcription factor 0.0213 0.3832 0.3832
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0213 0.3832 0.4775
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0116 0.1112 0.1112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.6452 0.804
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1236 0.1541
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Schistosoma mansoni zinc finger protein 0.0097 0.0566 0.0566
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0116 0.1112 0.1385
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0213 0.3832 0.5871
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0164 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.1112 0.1385
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0213 0.3832 0.3832
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.3832 0.4775
Brugia malayi hypothetical protein 0.0116 0.1112 0.1385
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0566 0.0566
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0213 0.3832 0.9271
Echinococcus granulosus ecdysone induced protein 78C 0.0213 0.3832 0.5871
Brugia malayi orphan nuclear receptor NR2E1 0.0097 0.0566 0.0706
Schistosoma mansoni nuclear receptor nhr-48 0.0097 0.0566 0.0566
Brugia malayi hypothetical protein 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0213 0.3832 0.3832
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0303 0.6372 0.794
Schistosoma mansoni nuclear receptor 0.0097 0.0566 0.0566
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0566 0.0566
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.3832 0.4775
Schistosoma mansoni nuclear receptor 0.0097 0.0566 0.0566
Onchocerca volvulus Protein ultraspiracle homolog 0.0213 0.3832 0.36
Schistosoma mansoni hypothetical protein 0.0082 0.0164 0.0164
Loa Loa (eye worm) nuclear receptor NHR-67 0.0097 0.0566 0.0706
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.3832 0.5871
Brugia malayi nuclear hormone receptor family member odr-7 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0213 0.3832 0.4775
Brugia malayi steroid hormone receptor 0.0213 0.3832 0.4775
Loa Loa (eye worm) hypothetical protein 0.0213 0.3832 0.4775
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0192 0.3262 0.789
Echinococcus multilocularis FTZ F1 alpha 0.0213 0.3832 0.9271
Loa Loa (eye worm) hypothetical protein 0.0097 0.0566 0.0706
Brugia malayi Nuclear hormone receptor E75 0.0097 0.0566 0.0706
Loa Loa (eye worm) hypothetical protein 0.0206 0.3651 0.4549
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0213 0.3832 0.4775
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0566 0.137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0566 0.0868
Brugia malayi photoreceptor-specific nuclear receptor 0.0213 0.3832 0.4775
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0213 0.3832 0.9271
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.1385
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0111 0.0959 0.1195

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7.07 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 16.31 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
Potency (functional) 0.6573 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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