Detailed information for compound 1267078

Basic information

Technical information
  • TDR Targets ID: 1267078
  • Name: 2-[(E)-2-(2-methoxyphenyl)ethenyl]-5-(2-pheny lethylamino)-1,3-oxazole-4-carbonitrile
  • MW: 345.394 | Formula: C21H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1nc(oc1NCCc1ccccc1)/C=C/c1ccccc1OC
  • InChi: 1S/C21H19N3O2/c1-25-19-10-6-5-9-17(19)11-12-20-24-18(15-22)21(26-20)23-14-13-16-7-3-2-4-8-16/h2-12,23H,13-14H2,1H3/b12-11+
  • InChiKey: XWSPRUZXJDSWRS-VAWYXSNFSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[2-(2-methoxyphenyl)ethenyl]-5-(2-phenylethylamino)-1,3-oxazole-4-carbonitrile
  • 2-[(E)-2-(2-methoxyphenyl)vinyl]-5-(2-phenylethylamino)oxazole-4-carbonitrile
  • 2-[2-(2-methoxyphenyl)vinyl]-5-(2-phenylethylamino)oxazole-4-carbonitrile
  • 2-[2-(2-methoxyphenyl)vinyl]-5-(2-phenylethylamino)-4-oxazolecarbonitrile
  • 2-[(E)-2-(2-methoxyphenyl)vinyl]-5-(2-phenylethylamino)-4-oxazolecarbonitrile
  • D151-0342
  • NCGC00116657-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Leishmania major cysteine peptidase A (CPA) 0.002 0.0021 0.0298
Schistosoma mansoni neuroligin 3 (S09 family) 0.0097 0.0967 0.0967
Loa Loa (eye worm) carboxylesterase 0.0576 0.684 1
Onchocerca volvulus 0.0286 0.3284 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.0474 1
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.0259 0.0348
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0021 0.0021
Brugia malayi Carboxylesterase family protein 0.0097 0.0967 0.1394
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0021 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0097 0.0967 1
Echinococcus multilocularis tumor protein p63 0.0408 0.4781 0.4772
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0035 0.002
Brugia malayi Carboxylesterase family protein 0.0097 0.0967 0.1394
Loa Loa (eye worm) hypothetical protein 0.0052 0.0405 0.0563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Onchocerca volvulus Peroxidasin homolog 0.004 0.0259 0.0728
Leishmania major trypanothione reductase 0.0057 0.0474 0.6596
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0107 0.0091
Schistosoma mansoni BC026374 protein (S09 family) 0.0097 0.0967 0.0967
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Echinococcus granulosus acetylcholinesterase 0.0576 0.684 0.6835
Loa Loa (eye worm) carboxylesterase 0.0097 0.0967 0.1387
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0259 0.0348
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0026 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0021 0.0298
Leishmania major cathepsin L-like protease 0.002 0.0021 0.0298
Echinococcus granulosus neuroligin 0.0097 0.0967 0.0953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Echinococcus multilocularis cysteine protease 0.002 0.0021 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0385 0.0385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Echinococcus multilocularis chromobox protein 1 0.0084 0.0806 0.0791
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0396 0.1148
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.155 1
Echinococcus granulosus BC026374 protein S09 family 0.0097 0.0967 0.0953
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0097 0.0967 0.6201
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0576 0.684 0.684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Schistosoma mansoni peroxidasin 0.004 0.0259 0.0259
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0474 0.0459
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0306 0.029
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Onchocerca volvulus Peroxidase homolog 0.004 0.0259 0.0728
Echinococcus multilocularis zinc finger protein 0.0024 0.0063 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0021 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0026 0.001
Brugia malayi Blistered cuticle protein 3 0.004 0.0259 0.0356
Brugia malayi Bromodomain containing protein 0.0091 0.0885 0.1273
Leishmania major cathepsin L-like protease 0.0077 0.0719 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0199 0.0184
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.155 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0468 0.0453
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0021 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Trypanosoma brucei trypanothione reductase 0.0057 0.0474 0.6596
Loa Loa (eye worm) hypothetical protein 0.0576 0.684 1
Plasmodium falciparum glutathione reductase 0.0057 0.0474 1
Brugia malayi Carboxylesterase family protein 0.0576 0.684 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0107 0.0091
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.155 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Brugia malayi Peroxidasin 0.004 0.0259 0.0356
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0026 0.0026
Echinococcus granulosus chromobox protein 1 0.0084 0.0806 0.0791
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0306 0.029
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0474 0.2985
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0021 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0352 0.1014
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0806 0.2417
Brugia malayi Animal haem peroxidase family protein 0.004 0.0259 0.0356
Leishmania major cathepsin L-like protease 0.002 0.0021 0.0298
Onchocerca volvulus Peroxidasin homolog 0.004 0.0259 0.0728
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0016 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0506 0.0711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0259 0.0348
Plasmodium vivax vivapain-2 0.002 0.0021 0.0116
Plasmodium vivax SET domain protein, putative 0.0036 0.0216 0.4358
Trichomonas vaginalis spcc417.12 protein, putative 0.0097 0.0967 0.2911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0021 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0021 0.0005
Onchocerca volvulus 0.006 0.0506 0.1486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0468 0.0468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0016 0.0224
Echinococcus multilocularis cysteine protease 0.002 0.0021 0.0005
Echinococcus multilocularis carboxylesterase 5A 0.0576 0.684 0.6835
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1372 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0474 0.0459
Echinococcus granulosus para nitrobenzyl esterase 0.0097 0.0967 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0183 0.0511
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0259 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Schistosoma mansoni acetylcholinesterase 0.0097 0.0967 0.0967
Mycobacterium tuberculosis Carboxylesterase LipT 0.0097 0.0967 0.6201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1372 0.8837
Schistosoma mansoni bromodomain containing protein 0.0076 0.0711 0.0711
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0474 0.0664
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0016 0.0224
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Echinococcus granulosus chromobox protein 1 0.0084 0.0806 0.0791
Echinococcus granulosus zinc finger protein 0.0024 0.0063 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0021 0.0005
Echinococcus multilocularis BC026374 protein (S09 family) 0.0097 0.0967 0.0953
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Onchocerca volvulus 0.0097 0.0967 0.2899
Plasmodium falciparum thioredoxin reductase 0.0057 0.0474 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0016 0.0224
Schistosoma mansoni gliotactin 0.0097 0.0967 0.0967
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0658 0.0643
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.047
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Brugia malayi glutathione reductase 0.0057 0.0474 0.0671
Loa Loa (eye worm) hypothetical protein 0.0085 0.0821 0.1173
Plasmodium vivax vivapain-2 0.002 0.0021 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Echinococcus granulosus carboxylesterase 5A 0.0576 0.684 0.6835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Treponema pallidum NADH oxidase 0.002 0.0016 0.5
Schistosoma mansoni zinc finger protein 0.0024 0.0063 0.0063
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0079 0.0085
Onchocerca volvulus 0.0097 0.0967 0.2899
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Onchocerca volvulus Chorion peroxidase homolog 0.004 0.0259 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0352 0.1028
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0016 0.0224
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0016 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Onchocerca volvulus 0.0097 0.0967 0.2899
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0097 0.0967 0.0953
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0516 0.7185
Brugia malayi Animal haem peroxidase family protein 0.004 0.0259 0.0356
Onchocerca volvulus 0.0037 0.0227 0.063
Onchocerca volvulus 0.004 0.0259 0.0728
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1372 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0637 0.8859
Schistosoma mansoni chromobox protein 0.0084 0.0806 0.0806
Brugia malayi Carboxylesterase family protein 0.0576 0.684 1
Schistosoma mansoni peroxidasin 0.004 0.0259 0.0259
Onchocerca volvulus 0.0097 0.0967 0.2899
Mycobacterium tuberculosis Probable reductase 0.013 0.1372 0.8837
Brugia malayi Animal haem peroxidase family protein 0.004 0.0259 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.0967 0.0967
Leishmania major cathepsin L-like protease 0.0077 0.0719 1
Onchocerca volvulus Peroxidase homolog 0.004 0.0259 0.0728
Onchocerca volvulus 0.004 0.0259 0.0728
Leishmania major cathepsin L-like protease 0.002 0.0021 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0016 0.0224
Leishmania major cathepsin L-like protease 0.0077 0.0719 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Brugia malayi PHD-finger family protein 0.003 0.0142 0.0185
Loa Loa (eye worm) glutathione reductase 0.0057 0.0474 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0183 0.0511
Echinococcus granulosus acetylcholinesterase 0.0576 0.684 0.6835
Brugia malayi Animal haem peroxidase family protein 0.004 0.0259 0.0356
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Brugia malayi hypothetical protein 0.004 0.0259 0.0356
Loa Loa (eye worm) hypothetical protein 0.0047 0.0352 0.0485
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0021 0.0116
Brugia malayi Animal haem peroxidase family protein 0.004 0.0259 0.0356
Loa Loa (eye worm) hypothetical protein 0.0576 0.684 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0097 0.0967 0.2911
Echinococcus granulosus cathepsin l1 0.002 0.0021 0.0005
Loa Loa (eye worm) acetylcholinesterase 1 0.0576 0.684 1
Brugia malayi Heterochromatin protein 1 0.0084 0.0806 0.1157
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0506 0.0506
Onchocerca volvulus 0.005 0.0385 0.1113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2858 0.416
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0021 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0352 0.1028
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0719 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0468 0.0453
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0967 0.1387
Brugia malayi Carboxylesterase family protein 0.0097 0.0967 0.1394
Brugia malayi Carboxylesterase family protein 0.0097 0.0967 0.1394
Echinococcus granulosus tumor protein p63 0.0408 0.4781 0.4772
Echinococcus multilocularis para nitrobenzyl esterase 0.0097 0.0967 0.0953
Plasmodium vivax glutathione reductase, putative 0.0057 0.0474 1
Loa Loa (eye worm) carboxylesterase 0.0097 0.0967 0.1387
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3284 1
Leishmania major cathepsin L-like protease 0.002 0.0021 0.0298
Onchocerca volvulus 0.004 0.0259 0.0728
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.155 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1372 0.8837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Echinococcus multilocularis acetylcholinesterase 0.0576 0.684 0.6835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0021 0.0116
Brugia malayi Pre-SET motif family protein 0.0036 0.0216 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1372 0.8837
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0021 0.0008
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0016 0.0224
Echinococcus multilocularis peroxidasin 0.004 0.0259 0.0243
Echinococcus granulosus peroxidasin 0.004 0.0259 0.0243
Toxoplasma gondii cathepsin CPL 0.002 0.0021 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0021 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0216 0.4358
Loa Loa (eye worm) hypothetical protein 0.0057 0.0468 0.0656
Onchocerca volvulus Dual oxidase homolog 0.004 0.0259 0.0728
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0016 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Brugia malayi Thioredoxin reductase 0.0057 0.0474 0.0671
Loa Loa (eye worm) hypothetical protein 0.0049 0.0377 0.0521
Brugia malayi hypothetical protein 0.0097 0.0967 0.1394
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0474 0.6596
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0097 0.0967 0.0953
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0806 0.0791
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0016 0.0224
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0021 0.0116
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0016 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0396 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0021 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0259 0.0348
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0097 0.0967 0.6201
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0806 0.115
Echinococcus multilocularis acetylcholinesterase 0.0576 0.684 0.6835
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0107 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0806 0.2417
Schistosoma mansoni chromobox protein 0.0084 0.0806 0.0806
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0396 0.1163
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0474 1
Onchocerca volvulus 0.0097 0.0967 0.2899
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0021 0.0008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.0967 0.0967
Brugia malayi Bromodomain containing protein 0.0046 0.0341 0.0476
Leishmania major cathepsin L-like protease 0.002 0.0021 0.0298
Brugia malayi chromobox protein homolog 3 0.0047 0.0352 0.0492
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0658 0.0643
Brugia malayi Pre-SET motif family protein 0.0251 0.2858 0.4164
Schistosoma mansoni hypothetical protein 0.0025 0.0079 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0021 0.5
Echinococcus multilocularis neuroligin 0.0097 0.0967 0.0953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0021 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0216 0.0216
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.0967 0.0967
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0348
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0216 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0016 0.0224
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0224
Entamoeba histolytica cysteine protease, putative 0.002 0.0021 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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