Detailed information for compound 1267346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.346 | Formula: C18H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1Cn1cc(Nc2ccccc2)c(=O)[nH]c1=O
  • InChi: 1S/C18H17N3O2/c1-13-7-5-6-8-14(13)11-21-12-16(17(22)20-18(21)23)19-15-9-3-2-4-10-15/h2-10,12,19H,11H2,1H3,(H,20,22,23)
  • InChiKey: JHSNFRAGBJZPBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.016 0.0109
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0907 1 1
Brugia malayi dihydrofolate reductase family protein 0.0132 0.1348 0.1303
Loa Loa (eye worm) hypothetical protein 0.0151 0.1554 0.151
Loa Loa (eye worm) thymidylate synthase 0.0325 0.3495 0.3461
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0132 0.1348 0.1303
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0307 0.0257
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0128 0.0128
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0907 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0307 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0307 0.025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.031
Schistosoma mansoni adenosylhomocysteinase 0.0561 0.6139 0.6139
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0396 0.0396
Echinococcus granulosus c-Jun N-terminal kinases 0.0233 0.2469 0.2469
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0059 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0128 0.0076
Schistosoma mansoni hypothetical protein 0.0184 0.1929 0.1929
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0059 0.0007
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0059 0.0059
Mycobacterium tuberculosis Conserved protein 0.0039 0.0307 0.0257
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0457 0.4973 0.4947
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0457 0.4973 0.4947
Brugia malayi hypothetical protein 0.0037 0.0284 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0608 0.0559
Loa Loa (eye worm) fibroinase 0.0017 0.0059 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0128 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0284 0.0284
Plasmodium falciparum adenosylhomocysteinase 0.0907 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.016 0.0109
Leishmania major cathepsin L-like protease 0.0064 0.0589 0.054
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0907 1 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0307 0.0257
Onchocerca volvulus 0.0039 0.0307 0.0724
Loa Loa (eye worm) dihydrofolate reductase 0.0132 0.1348 0.1303
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.2469 0.2469
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0128 0.0076
Echinococcus granulosus cathepsin l1 0.0017 0.0059 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0307 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.016 0.0109
Onchocerca volvulus 0.0039 0.0307 0.0724
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0128 0.5
Leishmania major cathepsin L-like protease 0.0064 0.0589 0.054
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0233 0.2469 0.2469
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.0227
Loa Loa (eye worm) adenosylhomocysteinase 0.0907 1 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.1595 0.1545
Leishmania major GTP-binding protein, putative 0.0023 0.0128 0.0076
Leishmania major S-adenosylhomocysteine hydrolase 0.0907 1 1
Schistosoma mansoni adenosylhomocysteinase 0.0561 0.6139 0.6139
Brugia malayi hypothetical protein 0.0154 0.1595 0.1551
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0052 0.0052
Echinococcus multilocularis geminin 0.0184 0.1929 0.1929
Trichomonas vaginalis ran, putative 0.0023 0.0128 0.007
Brugia malayi Importin beta-1 subunit 0.0031 0.022 0.0169
Mycobacterium tuberculosis Hypothetical protein 0.0154 0.1595 0.1551
Mycobacterium tuberculosis Conserved protein 0.0039 0.0307 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0608 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Mycobacterium ulcerans thymidylate synthase 0.0325 0.3495 0.3289
Brugia malayi Cathepsin L-like precursor 0.0017 0.0059 0.0007
Mycobacterium tuberculosis Conserved protein 0.0039 0.0307 0.0257
Onchocerca volvulus 0.0325 0.3495 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Brugia malayi RNA, U transporter 1 0.0089 0.0866 0.0819
Echinococcus multilocularis muscleblind protein 0.0151 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0031 0.022 0.0169
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.031
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.0227
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0396 0.0347
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0052 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0039 0.0307 0.0724
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0307 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Toxoplasma gondii cathepsin CPL 0.0017 0.0059 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1244 0.1199
Echinococcus granulosus importin subunit beta 1 0.0031 0.022 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0307 0.025
Leishmania major cathepsin L-like protease 0.0064 0.0589 0.054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0059 0.0059
Leishmania major importin beta-1 subunit, putative 0.0025 0.0154 0.0103
Brugia malayi beta-lactamase family protein 0.0039 0.0307 0.0257
Loa Loa (eye worm) hypothetical protein 0.0026 0.016 0.0109
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0128 0.0076
Brugia malayi Stress-activated protein kinase jnk-1 0.0233 0.2469 0.243
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0907 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Echinococcus multilocularis snurportin 1 0.0335 0.3611 0.3611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0307 0.0307
Leishmania major hypothetical protein, conserved 0.0039 0.0307 0.0257
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0307 0.0257
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0907 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.2666 0.2627
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0907 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0059 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0059 0.0007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0132 0.1348 0.1074
Leishmania major cathepsin L-like protease 0.0017 0.0059 0.0007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.2685 0.2647
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0608 0.0608
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1244 0.1199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Echinococcus multilocularis dihydrofolate reductase 0.0132 0.1348 0.1348
Brugia malayi follicle stimulating hormone receptor 0.0252 0.2685 0.2647
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0059 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.022 0.0169
Plasmodium vivax vivapain-2 0.0017 0.0059 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0307 0.0257
Schistosoma mansoni dihydrofolate reductase 0.0132 0.1348 0.1348
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.022 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0907 1 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.022 0.0169
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0132 0.1348 0.1074
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.1595 0.1551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0589 0.054
Schistosoma mansoni hypothetical protein 0.0037 0.0284 0.0284
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.016 0.0109
Schistosoma mansoni importin beta-1 0.0031 0.022 0.022
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.022 0.0169
Echinococcus multilocularis adenosylhomocysteinase 0.0907 1 1
Brugia malayi hypothetical protein 0.0026 0.016 0.0109
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0325 0.3495 0.3461
Schistosoma mansoni hypothetical protein 0.0335 0.3611 0.3611
Trichomonas vaginalis esterase, putative 0.0039 0.0307 0.025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Brugia malayi beta-lactamase family protein 0.0039 0.0307 0.0257
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Brugia malayi Muscleblind-like protein 0.0151 0.1554 0.151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0608 0.0559
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1554 0.1554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0608 0.0608
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.031
Echinococcus multilocularis cysteine protease 0.0017 0.0059 0.0059
Loa Loa (eye worm) beta-lactamase 0.0039 0.0307 0.0257
Schistosoma mansoni ran 0.0023 0.0128 0.0128
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0325 0.3495 0.3289
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0285 0.305 0.3009
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0907 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0284 0.0284
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0325 0.3495 0.3495
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0907 1 1
Toxoplasma gondii adenosylhomocysteinase, putative 0.0907 1 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0059 0.0007
Entamoeba histolytica Ran family GTPase 0.0023 0.0128 0.007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0059 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0396 0.0396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.3611 0.3578
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0096
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0307 0.0257
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.0227
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0154 0.0096
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.0227
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0396 0.0347
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0589 0.054
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0589 0.054
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0307 0.0257
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0154 0.0096
Echinococcus granulosus adenosylhomocysteinase 0.0907 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0059 0.0007
Brugia malayi Dihydrofolate reductase 0.0132 0.1348 0.1303
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0052 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0608 0.0608
Echinococcus granulosus geminin 0.0184 0.1929 0.1929
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0128 0.0076
Leishmania major cathepsin L-like protease 0.0017 0.0059 0.0007
Schistosoma mansoni hypothetical protein 0.0184 0.1929 0.1929
Entamoeba histolytica adenosylhomocysteinase, putative 0.0907 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0307 0.025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0154 0.0103
Brugia malayi MH2 domain containing protein 0.0123 0.1244 0.1199
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0128 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0589 0.054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0284 0.0284
Schistosoma mansoni adenosylhomocysteinase 0.0907 1 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0457 0.4973 0.4947
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0059 0.0007
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0457 0.4973 0.4947
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0307 0.0257
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0457 0.4973 0.4947
Schistosoma mansoni ran 0.0023 0.0128 0.0128
Schistosoma mansoni adenosylhomocysteinase 0.0561 0.6139 0.6139
Plasmodium vivax vivapain-2 0.0017 0.0059 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0059 0.0059
Echinococcus multilocularis thymidylate synthase 0.0325 0.3495 0.3495
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0396 0.0396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0052 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0307 0.025
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0907 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0128 0.0076
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0059 0.0059
Brugia malayi beta-lactamase 0.0039 0.0307 0.0257
Echinococcus multilocularis cysteine protease 0.0017 0.0059 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0396 0.0396
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0059 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.016 0.0109
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0233 0.2469 0.243
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0527 0.0477
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0307 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0307 0.0257
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0059 0.0007
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0059 0.0059
Schistosoma mansoni adenosylhomocysteinase 0.0561 0.6139 0.6139
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0154 0.0096
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0435 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0307 0.0307
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0059 0.0007
Brugia malayi thymidylate synthase 0.0325 0.3495 0.3461
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.016 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0307 0.0257
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0257
Echinococcus granulosus snurportin 1 0.0335 0.3611 0.3611
Echinococcus granulosus muscleblind protein 0.0151 0.1554 0.1554
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0128 0.0128
Chlamydia trachomatis dihydrofolate reductase 0.0132 0.1348 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.1554 0.151
Leishmania major cathepsin L-like protease 0.0017 0.0059 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0307 0.0257
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0307 0.0307
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0307 0.0307
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0128 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0307 0.0257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0396 0.0396
Echinococcus multilocularis importin subunit beta 1 0.0031 0.022 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0396 0.0396
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0059 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0052 0.0052
Plasmodium falciparum importin beta, putative 0.0031 0.022 0.0169
Echinococcus granulosus thymidylate synthase 0.0325 0.3495 0.3495
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0396 0.0396
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.016 0.0109
Loa Loa (eye worm) cysteine protease 0.0017 0.0059 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0589 0.054
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0457 0.4973 0.4947
Leishmania major hypothetical protein, conserved 0.0026 0.016 0.0109
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0608 0.0559
Brugia malayi hypothetical protein 0.0017 0.0057 0.0005
Echinococcus granulosus dihydrofolate reductase 0.0132 0.1348 0.1348

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 uM Cytotoxicity against human CEM-SS cells assessed as cell viability by XTT assay ChEMBL. 21035347

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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