TDR Targets

Basic information

Technical information

TDR Targets ID: 1267449
Name: 5-[3,4-dihydro-1H-isoquinolin-2-yl-(3,4,5-tri methoxyphenyl)methyl]-2-methyl-[1,3]thiazolo[ 2,3-e][1,2,4]triazol-6-ol
MW: 466.553 | Formula: C24H26N4O4S
H donors: 1 H acceptors: 3 LogP: 4.24 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)C(c1sc2n(c1O)nc(n2)C)N1CCc2c(C1)cccc2
InChi: 1S/C24H26N4O4S/c1-14-25-24-28(26-14)23(29)22(33-24)20(27-10-9-15-7-5-6-8-16(15)13-27)17-11-18(30-2)21(32-4)19(12-17)31-3/h5-8,11-12,20,29H,9-10,13H2,1-4H3
InChiKey: GQNFXFBJSJGNCY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

5-[3,4-dihydro-1H-isoquinolin-2-yl-(3,4,5-trimethoxyphenyl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
5-[3,4-dihydro-1H-isoquinolin-2-yl-(3,4,5-trimethoxyphenyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol
MLS000101796
SMR000017266

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0247	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0247	1	1
Plasmodium vivax	phosphoglycerate kinase, putative	0.0188	0.7299	1
Chlamydia trachomatis	phosphoglycerate kinase	0.0188	0.7299	0.5
Schistosoma mansoni	hypothetical protein	0.0187	0.7262	0.6479
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0188	0.7299	1
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0188	0.7299	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0247	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0247	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0247	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0116	0.4047	0.4047
Brugia malayi	nuclear hormone receptor	0.0116	0.4047	0.4047
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Brugia malayi	Nuclear hormone receptor-like 1	0.0247	1	1
Trypanosoma brucei	phosphoglycerate kinase	0.0188	0.7299	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0247	1	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Brugia malayi	hypothetical protein	0.013	0.4684	0.4684
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Brugia malayi	nuclear receptor RXR	0.013	0.4684	0.4684
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0188	0.7299	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0116	0.4047	0.2344
Brugia malayi	Nuclear hormone receptor-like 1	0.013	0.4684	0.4684
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0116	0.4047	0.2344
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2224	0.2224
Schistosoma mansoni	phosphoglycerate kinase	0.0188	0.7299	0.6527
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0247	1	1
Giardia lamblia	Phosphoglycerate kinase	0.0188	0.7299	0.5
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0116	0.4047	0.4047
Schistosoma mansoni	nuclear hormone receptor	0.0116	0.4047	0.2344
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0247	1	1
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0188	0.7299	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.4684	0.4684
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0188	0.7299	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0116	0.4047	0.4047
Brugia malayi	TAR-binding protein	0.0076	0.2224	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Onchocerca volvulus		0.0247	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0247	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0247	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0247	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0247	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0116	0.4047	0.4047
Brugia malayi	conserved hypotetical protein	0.0116	0.4047	0.4047
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0188	0.7299	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0247	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0116	0.4047	0.4047
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0247	1	1
Loa Loa (eye worm)	DR-78	0.0116	0.4047	0.4047
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0247	1	1
Brugia malayi	Phosphoglycerate kinase	0.0069	0.1876	0.1876
Echinococcus multilocularis	geminin	0.0187	0.7262	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Brugia malayi	ecdysone receptor	0.0116	0.4047	0.4047
Echinococcus granulosus	phosphoglycerate kinase 1	0.0188	0.7299	0.6527
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0188	0.7299	1
Brugia malayi	nuclear receptor NHR-67	0.0116	0.4047	0.4047
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0247	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0247	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0247	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0116	0.4047	0.2344
Loa Loa (eye worm)	hypothetical protein	0.013	0.4684	0.4684
Brugia malayi	hypothetical protein	0.0116	0.4047	0.4047
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0188	0.7299	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0247	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0116	0.4047	0.2344
Schistosoma mansoni	nuclear receptor	0.0116	0.4047	0.2344
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0247	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0247	1	1
Brugia malayi	nuclear receptor NHR-88	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0247	1	1
Brugia malayi	steroid hormone receptor	0.0247	1	1
Treponema pallidum	phosphoglycerate kinase	0.0188	0.7299	0.5
Schistosoma mansoni	phosphoglycerate kinase	0.0188	0.7299	0.6527
Loa Loa (eye worm)	hypothetical protein	0.0188	0.7299	0.7299
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0247	1	1
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0069	0.1876	0.257
Schistosoma mansoni	hypothetical protein	0.0187	0.7262	0.6479
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.013	0.4684	0.3164
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.4684	0.4684
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0116	0.4047	0.4047
Brugia malayi	RNA binding protein	0.0076	0.2224	0.2224
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.013	0.4684	0.3164
Schistosoma mansoni	zinc finger protein	0.0116	0.4047	0.2344
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0116	0.4047	0.2344
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0116	0.4047	0.2344
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0188	0.7299	0.6527
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0247	1	1
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0247	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0116	0.4047	0.2344
Brugia malayi	hypothetical protein	0.0116	0.4047	0.4047
Loa Loa (eye worm)	hypothetical protein	0.013	0.4684	0.4684
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0247	1	1
Schistosoma mansoni	nuclear receptor	0.0116	0.4047	0.2344
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0116	0.4047	0.2344
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.4684	0.4684
Brugia malayi	Nuclear hormone receptor-like 1	0.013	0.4684	0.4684
Echinococcus multilocularis	nuclear receptor nhr 48	0.0116	0.4047	0.2344
Brugia malayi	nuclear hormone receptor family member odr-7	0.0116	0.4047	0.4047
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0247	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0247	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0247	1	1
Brugia malayi	tailless protein	0.0116	0.4047	0.4047
Schistosoma mansoni	thyroid hormone receptor	0.0247	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0247	1	1
Schistosoma mansoni	coup transcription factor	0.0247	1	1
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0188	0.7299	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.013	0.4684	0.4684
Echinococcus granulosus	thyroid hormone receptor alpha	0.0116	0.4047	0.2344
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0247	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0247	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0116	0.4047	0.2344
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0247	1	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0188	0.7299	1
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0188	0.7299	0.5
Brugia malayi	Phosphoglycerate kinase	0.0188	0.7299	0.7299
Brugia malayi	hypothetical protein	0.013	0.4684	0.4684
Echinococcus granulosus	geminin	0.0187	0.7262	0.6479
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0116	0.4047	0.2344
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Brugia malayi	nuclear receptor RXR	0.0116	0.4047	0.4047
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0247	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.013	0.4684	0.3164
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0247	1	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Brugia malayi	Steroid receptor seven-up type 2	0.0247	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0247	1	1
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0188	0.7299	0.5
Plasmodium falciparum	phosphoglycerate kinase	0.0188	0.7299	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0247	1	1
Mycobacterium ulcerans	phosphoglycerate kinase	0.0188	0.7299	0.5
Brugia malayi	nuclear hormone receptor	0.0247	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0116	0.4047	0.2344
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0116	0.4047	0.4047
Schistosoma mansoni	nuclear hormone receptor	0.0116	0.4047	0.2344
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4047	0.4047
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0116	0.4047	0.2344
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0247	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0247	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2224	0.2224
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Loa Loa (eye worm)	hypothetical protein	0.0247	1	1
Brugia malayi	nuclear receptor NHR-88	0.0116	0.4047	0.4047
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0069	0.1876	0.257
Onchocerca volvulus	Bile acid receptor homolog	0.0247	1	1
Trypanosoma brucei	phosphoglycerate kinase	0.0188	0.7299	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.013	0.4684	0.3164
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0247	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2224	0.2224
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0116	0.4047	0.2344
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0247	1	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2224	0.2224
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0247	1	1
Trypanosoma brucei	phosphoglycerate kinase	0.0069	0.1876	0.257
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0116	0.4047	0.4047

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.8584 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1373168

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1267449