Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2041 | 0.2409 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2939 | 0.2939 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8474 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8474 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2939 | 0.3468 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2939 | 0.3468 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2041 | 0.2409 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2939 | 0.3468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2939 | 0.2939 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2939 | 0.2939 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0991 | 0.117 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2939 | 0.3468 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0991 | 0.117 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2939 | 0.3468 |
Leishmania major | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8474 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2939 | 0.2939 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2041 | 0.2409 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0991 | 0.0991 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2939 | 0.2939 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2939 | 0.3468 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2041 | 0.2409 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.