Detailed information for compound 1267808
Basic information
Technical information
- TDR Targets ID: 1267808
- Name: 3-(2-bromophenoxy)-N-methyl-N-(phenylmethyl)p ropan-1-amine
- MW: 334.251 | Formula: C17H20BrNO
-
H donors: 0
H acceptors: 0
LogP: 4.47
Rotable bonds: 7
Rule of 5 violations (Lipinski): 1 - SMILES: CN(Cc1ccccc1)CCCOc1ccccc1Br
- InChi: 1S/C17H20BrNO/c1-19(14-15-8-3-2-4-9-15)12-7-13-20-17-11-6-5-10-16(17)18/h2-6,8-11H,7,12-14H2,1H3
- InChiKey: OOTHRCRQEJHQDV-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
- benzyl-[3-(2-bromophenoxy)propyl]-methyl-amine
- N-benzyl-3-(2-bromophenoxy)-N-methyl-1-propanamine
- SMR000291856
- MLS000675895
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
| Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
| Species | Potential target | Known druggable target | Length | Alignment span | Identity |
|---|---|---|---|---|---|
| Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0069 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | lamin | 0.0033 | 0.2936 | 0.2709 |
| Echinococcus granulosus | serotonin receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | myosin xvIII | 0.0069 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.0069 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0311 | 0.0311 |
| Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0311 | 0.0311 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Schistosoma mansoni | histamine h1 receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | fmrfamide receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | sulfakinin receptor protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 2 | 0.0069 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2936 | 0.2936 |
| Echinococcus granulosus | lamin | 0.0033 | 0.2936 | 0.2709 |
| Brugia malayi | follicle stimulating hormone receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2936 | 0.2936 |
| Schistosoma mansoni | biogenic amine receptor | 0.0069 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | G protein coupled receptor 139 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | orexin receptor type 2 | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | fmrfamide receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0069 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Loa Loa (eye worm) | melatonin receptor type 1A | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide s receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0069 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor NPR1 | 0.0069 | 1 | 1 |
| Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0069 | 1 | 1 |
| Schistosoma mansoni | adenoreceptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | sex peptide receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.8303 | 0.8303 |
| Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2936 | 0.2709 |
| Schistosoma mansoni | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0069 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g-protein coupled receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0069 | 1 | 1 |
| Brugia malayi | GnHR receptor homolog | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0311 | 0.0311 |
| Schistosoma mansoni | amine GPCR | 0.0069 | 1 | 1 |
| Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | somatostatin receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide s receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | musashi | 0.0033 | 0.2936 | 0.2709 |
| Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2936 | 0.2936 |
| Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | dro:myosuppressin receptor | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus multilocularis | sex peptide receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.0069 | 1 | 1 |
| Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2936 | 0.2936 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.2821 |
| Brugia malayi | intermediate filament protein | 0.0033 | 0.2936 | 0.2936 |
| Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | allatostatin A receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | somatostatin receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0069 | 1 | 1 |
| Brugia malayi | RE15519p | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Brugia malayi | G-protein coupled receptor | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | ORL1-like opioid receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Dopamine receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | orexin receptor type 2 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | larval opioid receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide f receptor 76f | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4604 | 0.4604 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g-protein coupled receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | dro:myosuppressin receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0069 | 1 | 1 |
| Echinococcus granulosus | fmrfamide receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | growth hormone secretagogue receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.0069 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1 | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8303 | 0.8303 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0069 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2936 | 0.2709 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0069 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0069 | 1 | 1 |
| Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0069 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4604 | 0.443 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | lamin | 0.0033 | 0.2936 | 0.2709 |
| Brugia malayi | Melatonin receptor type 1A | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | 7tm_1 domain containing protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Schistosoma mansoni | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2936 | 0.2709 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Schistosoma mansoni | lamin | 0.0033 | 0.2936 | 0.2709 |
| Brugia malayi | AKH receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0069 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0069 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.0069 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.8303 | 0.8303 |
| Schistosoma mansoni | amine GPCR | 0.0069 | 1 | 1 |
| Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0311 | 0.0311 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0069 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0069 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus granulosus | allatostatin A receptor | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Schistosoma mansoni | opsin-like receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0069 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0069 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2936 | 0.2709 |
| Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4604 | 0.4604 |
| Onchocerca volvulus | 0.0069 | 1 | 1 | |
| Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.8303 | 0.8303 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled receptor 139 | 0.0069 | 1 | 1 |
| Loa Loa (eye worm) | TYRA-2 protein | 0.0069 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1363956
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.