Detailed information for compound 1267885

Basic information

Technical information
  • TDR Targets ID: 1267885
  • Name: methyl N-(4-methoxyphenyl)-N-(4-methyl-2-sulf anylidene-1,3-dioxa-2$l^{5}-phosphacyclohex-2 -yl)carbamate
  • MW: 331.324 | Formula: C13H18NO5PS
  • H donors: 0 H acceptors: 1 LogP: 3.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)N(P1(=S)OCCC(O1)C)c1ccc(cc1)OC
  • InChi: 1S/C13H18NO5PS/c1-10-8-9-18-20(21,19-10)14(13(15)17-3)11-4-6-12(16-2)7-5-11/h4-7,10H,8-9H2,1-3H3
  • InChiKey: XLRMRXUOBQKOTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl N-(4-methoxyphenyl)-N-(4-methyl-2-thioxo-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl)carbamate
  • N-(4-methoxyphenyl)-N-(4-methyl-2-thioxo-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl)carbamic acid methyl ester
  • ChemDiv3_005653
  • MLS000043492
  • SMR000020309
  • methyl 4-methoxyphenyl(4-methyl-2-sulfido-1,3,2-dioxaphosphinan-2-yl)carbamate
  • IDI1_023563

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0895 0.1051
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Echinococcus multilocularis protein dispatched 1 0.005 0.1079 0.1079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0947 0.1397
Trypanosoma brucei RNA helicase, putative 0.0121 0.3175 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0703 0.0167
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0427 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0324 0.1129
Echinococcus multilocularis protein patched 0.0044 0.0895 0.0895
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0703 0.0903
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1112 0.0716
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0043 0.0848 0.1237
Loa Loa (eye worm) hypothetical protein 0.0047 0.0985 0.1166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0657 0.0744
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0296 0.0296
Echinococcus multilocularis tumor protein p63 0.0353 1 1
Schistosoma mansoni lipoxygenase 0.0024 0.0296 0.0348
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0296 0.0296
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.3927 0.3927
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0077
Onchocerca volvulus 0.0025 0.0324 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0703 0.0167
Schistosoma mansoni rab6-interacting 0.0024 0.0296 0.0348
Entamoeba histolytica hypothetical protein 0.0038 0.0702 0.1435
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0985 0.1226
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0703 0.0167
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2958 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0296 0.161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.1063 0.1583
Onchocerca volvulus 0.0038 0.0703 0.0875
Brugia malayi CHE-14 protein 0.0044 0.0895 0.1097
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1774 0.1774
Echinococcus multilocularis chromobox protein 1 0.0084 0.2075 0.2075
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0324 0.0365
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0427 0.1756
Onchocerca volvulus 0.005 0.1063 0.1324
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2958 0.2958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0947 0.1397
Giardia lamblia Kinase, PLK 0.0114 0.2958 1
Echinococcus granulosus GPCR family 2 0.0016 0.008 0.008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1756 0.1756
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1756 0.1756
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1756 0.9889
Echinococcus granulosus chromobox protein 1 0.0084 0.2075 0.2075
Onchocerca volvulus 0.0017 0.0083 0.0104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.008 0.008
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0895 0.0895
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0044 0.0895 0.1051
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0703 0.0703
Mycobacterium tuberculosis Conserved protein 0.0038 0.0703 0.0903
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0703 0.5794
Entamoeba histolytica hypothetical protein 0.0038 0.0702 0.1435
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.1117 0.167
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0895 0.0895
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0702 0.0702
Onchocerca volvulus 0.0286 0.8029 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0703 0.0903
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0703 0.0903
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1774 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Brugia malayi beta-lactamase family protein 0.0038 0.0703 0.0851
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0324 0.0365
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0227 0.629 0.629
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2958 0.3708
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0702 0.1002
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1756 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0703 0.2077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0703 0.1003
Loa Loa (eye worm) acetyltransferase 0.0175 0.4755 0.6024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0657 0.0657
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.2555 0.3985
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0703 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0703 0.0903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0324 0.0315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7005 0.8922
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.1774 0.2729
Loa Loa (eye worm) hypothetical protein 0.0052 0.1117 0.1337
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0985 0.0545
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1129 0.1397
Brugia malayi Doublecortin family protein 0.0024 0.0296 0.0329
Mycobacterium ulcerans beta-lactamase 0.0038 0.0703 0.3446
Brugia malayi hypothetical protein 0.0038 0.0702 0.085
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0703 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1756 0.9889
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0703 0.0903
Brugia malayi hypothetical protein 0.0024 0.0296 0.0329
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0703 0.0851
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0703 0.0703
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2075 0.2008
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2958 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0703 0.1005
Onchocerca volvulus 0.0024 0.0296 0.0369
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0427 0.2953
Trypanosoma brucei polo-like protein kinase 0.0114 0.2958 0.921
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1129 0.1397
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1112 0.1112
Schistosoma mansoni lipoxygenase 0.0067 0.156 0.2383
Loa Loa (eye worm) beta-lactamase 0.0038 0.0703 0.0803
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0929
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.156 0.156
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0296 0.0279
Echinococcus multilocularis chromobox protein 1 0.0084 0.2075 0.2075
Loa Loa (eye worm) hypothetical protein 0.0103 0.2626 0.3281
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0296 0.0296
Onchocerca volvulus 0.0052 0.1117 0.1391
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1259 0.0913
Mycobacterium ulcerans hypothetical protein 0.0025 0.0324 0.1129
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.7841 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0427 0.0389
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.01 0.2555 0.3189
Schistosoma mansoni polycystin 1-related 0.0024 0.0296 0.0348
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.008 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.2555 0.2555
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0427 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0929
Brugia malayi chromobox protein homolog 3 0.0047 0.0985 0.1212
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.2626 0.2626
Brugia malayi hypothetical protein 0.0024 0.0296 0.0329
Echinococcus granulosus RUN 0.0024 0.0296 0.0296
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1756 0.27
Mycobacterium leprae Probable lipase LipE 0.0038 0.0703 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0618 0.0618
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2075 0.2571
Echinococcus granulosus leukotriene A 4 hydrolase 0.0227 0.629 0.629
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1756 0.27
Onchocerca volvulus 0.0038 0.0703 0.0875
Echinococcus granulosus expressed conserved protein 0.0097 0.2442 0.2442
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.014 0.0045
Brugia malayi Pre-SET motif family protein 0.0251 0.7005 0.8928
Schistosoma mansoni hypothetical protein 0.0121 0.3175 0.4984
Schistosoma mansoni hypothetical protein 0.0036 0.0643 0.0908
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0703 0.0903
Mycobacterium tuberculosis Conserved protein 0.0038 0.0703 0.0903
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.2555 0.2555
Echinococcus multilocularis RUN 0.0024 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Schistosoma mansoni hypothetical protein 0.0043 0.0848 0.1237
Entamoeba histolytica hypothetical protein 0.0038 0.0702 0.1435
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4755 0.7529
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1112 0.5153
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0657 0.0657
Mycobacterium ulcerans hypothetical protein 0.0038 0.0703 0.3446
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0054 0.1188 0.1428
Onchocerca volvulus 0.0038 0.0703 0.0875
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2958 0.3684
Brugia malayi beta-lactamase family protein 0.0038 0.0703 0.0851
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0324 0.1129
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0947 0.1397
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0324 0.0326
Onchocerca volvulus 0.01 0.2555 0.3182
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0985 0.2511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0947 0.1164
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2958 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0324 0.1129
Schistosoma mansoni kinase 0.0058 0.1303 0.1971
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.1774 0.2224
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0324 0.1129
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1112 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0324 0.1129
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0985 0.0545
Onchocerca volvulus 0.0037 0.0684 0.0852
Schistosoma mansoni patched 1 0.0044 0.0895 0.1313
Schistosoma mansoni rab6-interacting 0.0024 0.0296 0.0348
Schistosoma mansoni hypothetical protein 0.0043 0.0848 0.1237
Brugia malayi Heterochromatin protein 1 0.0084 0.2075 0.2609
Loa Loa (eye worm) hypothetical protein 0.0036 0.0643 0.0726
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0643 0.0775
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.2673 0.4176
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0227 0.629 1
Brugia malayi beta-lactamase 0.0038 0.0703 0.0851
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0929
Brugia malayi follicle stimulating hormone receptor 0.028 0.7841 1
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.3927 0.3927
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0427 1
Schistosoma mansoni chromobox protein 0.0084 0.2075 0.3213
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0703 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0895 0.0425
Brugia malayi hypothetical protein 0.0104 0.2672 0.3375
Mycobacterium ulcerans lipase LipD 0.0038 0.0703 0.3446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.008
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4755 0.6044
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2075 0.2008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.109 0.1358
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.1774 0.2534
Schistosoma mansoni loxhd1 0.0024 0.0296 0.0348
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0703 0.0803
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2958 0.3193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0684 0.0779
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0324 0.1129
Trichomonas vaginalis chromobox protein, putative 0.0051 0.109 0.0687
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Echinococcus multilocularis expressed conserved protein 0.0097 0.2442 0.2442
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0427 0.0482
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0296 0.1851
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.156 0.156
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0296 0.0296
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0703 0.0903
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0702 0.0702
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2958 0.2958
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1112 0.5153
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0427 0.3395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0947 0.0947
Entamoeba histolytica hypothetical protein 0.0028 0.0427 0.0389
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1112 0.0716
Schistosoma mansoni hypothetical protein 0.0043 0.0848 0.1237
Onchocerca volvulus 0.0024 0.0296 0.0369
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0985 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1499 0.1829
Echinococcus multilocularis GPCR, family 2 0.0016 0.008 0.008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1756 0.5438
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0947 0.0947
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0703 0.0167
Schistosoma mansoni chromobox protein 0.0084 0.2075 0.3213
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.2555 0.3224
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.2626 0.8741
Loa Loa (eye worm) hypothetical protein 0.0025 0.0324 0.0315
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.1774 0.5507
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1756 0.2507
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1129 0.1352
Loa Loa (eye worm) hypothetical protein 0.0025 0.0324 0.0315
Schistosoma mansoni hypothetical protein 0.0024 0.0296 0.0348
Brugia malayi Latrophilin receptor protein 2 0.0016 0.008 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0077
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.2626 0.2626
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0227 0.629 0.8001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0703 0.3446
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0803
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.6678 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1129 0.1352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0657 0.1732
Entamoeba histolytica hypothetical protein 0.0038 0.0702 0.1435
Trichomonas vaginalis esterase, putative 0.0038 0.0703 0.0167
Mycobacterium tuberculosis Conserved protein 0.0038 0.0703 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2958 0.4634
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0324 0.1129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0324 0.0326
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0279
Leishmania major hypothetical protein, conserved 0.0038 0.0703 0.1438
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0427 0.1756
Trichomonas vaginalis chromobox protein, putative 0.0051 0.109 0.0687
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0947 0.1118
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2958 0.3741
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0895 0.0895
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4755 0.4755
Brugia malayi Pre-SET motif family protein 0.0036 0.0657 0.0792
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1774 0.1774
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2958 1
Echinococcus granulosus chromobox protein 1 0.0084 0.2075 0.2075
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8029 1
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0427 0.2708
Plasmodium vivax SET domain protein, putative 0.0036 0.0657 0.5322
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1259 0.0913
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0657 0.0657
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0703 0.3446
Schistosoma mansoni hypothetical protein 0.0038 0.0702 0.1002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1774 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.2626 0.3316
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.461 0.461
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0324 0.0365
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1756 0.9889

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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