Detailed information for compound 1268275

Basic information

Technical information
  • TDR Targets ID: 1268275
  • Name: 6-[(4-methylphenoxy)methyl]-3-(1,4,5,6-tetrah ydrocyclopenta[d]pyrazol-3-yl)-[1,2,4]triazol o[3,4-b][1,3,4]thiadiazole
  • MW: 352.414 | Formula: C17H16N6OS
  • H donors: 1 H acceptors: 4 LogP: 2.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCc1nn2c(s1)nnc2c1[nH]nc2c1CCC2
  • InChi: 1S/C17H16N6OS/c1-10-5-7-11(8-6-10)24-9-14-22-23-16(20-21-17(23)25-14)15-12-3-2-4-13(12)18-19-15/h5-8H,2-4,9H2,1H3,(H,18,19)
  • InChiKey: IDJLBPDLAQCIBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ST5424073
  • MLS000083016
  • SMR000046616

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 alpha 0.0247 0.6316 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0116 0.2242 0.355
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Schistosoma mansoni retinoid-x-receptor (RXR) 0.013 0.2678 0.4241
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Schistosoma mansoni nuclear receptor nhr-48 0.0116 0.2242 0.355
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0247 0.6316 1
Echinococcus multilocularis FTZ F1 alpha 0.0247 0.6316 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Brugia malayi ecdysteroid receptor 0.0247 0.6316 0.86
Echinococcus multilocularis ecdysone induced protein 78C 0.0247 0.6316 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.013 0.2678 0.4241
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.4752 0.7524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0247 0.6316 0.86
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4607 0.5
Brugia malayi ecdysone receptor 0.0116 0.2242 0.3053
Schistosoma mansoni zinc finger protein 0.0116 0.2242 0.355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0247 0.6316 0.86
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0207 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0247 0.6316 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0116 0.2242 0.355
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Brugia malayi conserved hypotetical protein 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.013 0.2678 0.3647
Loa Loa (eye worm) nuclear hormone receptor 0.0116 0.2242 0.3053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0116 0.2242 0.355
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0247 0.6316 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.013 0.2678 0.3647
Schistosoma mansoni retinoic acid receptor RXR 0.0247 0.6316 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0116 0.2242 0.3053
Schistosoma mansoni alpha-glucosidase 0.0169 0.3896 0.6169
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0116 0.2242 0.355
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Onchocerca volvulus Bile acid receptor homolog 0.0247 0.6316 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0116 0.2242 0.0197
Brugia malayi nuclear receptor RXR 0.0116 0.2242 0.3053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0247 0.6316 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0116 0.2242 0.3053
Echinococcus granulosus ecdysone induced protein 78C 0.0247 0.6316 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0247 0.6316 0.86
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0116 0.2242 0.355
Mycobacterium ulcerans hypothetical protein 0.0192 0.4607 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4752 0.7524
Echinococcus granulosus Nuclear hormone receptor HR96 0.0116 0.2242 0.355
Onchocerca volvulus Protein ultraspiracle homolog 0.0247 0.6316 1
Brugia malayi Nuclear hormone receptor E75 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0247 0.6316 0.86
Loa Loa (eye worm) hypothetical protein 0.013 0.2678 0.3647
Schistosoma mansoni RAR-like nuclear receptor 0.0247 0.6316 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.013 0.2678 0.4241
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0247 0.6316 0.86
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.2678 0.3647
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0247 0.6316 0.86
Schistosoma mansoni coup transcription factor 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0207 0.0207
Schistosoma mansoni nuclear receptor 0.0116 0.2242 0.355
Brugia malayi hypothetical protein 0.013 0.2678 0.3647
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0247 0.6316 1
Brugia malayi nuclear hormone receptor 0.0247 0.6316 0.86
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0247 0.6316 0.86
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0247 0.6316 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0247 0.6316 0.86
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0207 0.0207
Echinococcus granulosus nuclear receptor nhr 48 0.0116 0.2242 0.355
Brugia malayi steroid hormone receptor 0.0247 0.6316 0.86
Echinococcus multilocularis thyroid hormone receptor alpha 0.0247 0.6316 1
Brugia malayi follicle stimulating hormone receptor 0.028 0.7344 1
Schistosoma mansoni nuclear receptor 0.0116 0.2242 0.355
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Schistosoma mansoni thyroid hormone receptor 0.0247 0.6316 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0247 0.6316 0.86
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Brugia malayi orphan nuclear receptor NR2E1 0.0116 0.2242 0.3053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0247 0.6316 1
Loa Loa (eye worm) steroid hormone receptor 0.0247 0.6316 0.86
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0247 0.6316 0.86
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.2678 0.3647
Onchocerca volvulus 0.0116 0.2242 0.0197
Onchocerca volvulus 0.0247 0.6316 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0116 0.2242 0.355
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3998 0.3998
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0247 0.6316 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0116 0.2242 0.3053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.013 0.2678 0.3647
Brugia malayi nuclear hormone receptor 0.0116 0.2242 0.3053
Brugia malayi nuclear receptor RXR 0.013 0.2678 0.3647
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0207 0.0207
Loa Loa (eye worm) nuclear receptor NHR-67 0.0116 0.2242 0.3053
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0247 0.6316 0.86
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0116 0.2242 0.355
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0247 0.6316 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0247 0.6316 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Schistosoma mansoni alpha-glucosidase 0.0169 0.3896 0.6169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0247 0.6316 0.86
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0247 0.6316 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0247 0.6316 0.86
Schistosoma mansoni nuclear hormone receptor 0.0116 0.2242 0.355
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3998 0.3998
Toxoplasma gondii hypothetical protein 0.0059 0.0443 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0247 0.6316 0.86
Brugia malayi hypothetical protein 0.0116 0.2242 0.3053
Schistosoma mansoni nuclear hormone receptor 0.0116 0.2242 0.355
Brugia malayi photoreceptor-specific nuclear receptor 0.0247 0.6316 0.86
Onchocerca volvulus 0.0116 0.2242 0.0197
Schistosoma mansoni nuclear hormone receptor 0.0247 0.6316 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.013 0.2678 0.4241
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0116 0.2242 0.0197
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Brugia malayi tailless protein 0.0116 0.2242 0.3053
Brugia malayi nuclear receptor NHR-67 0.0116 0.2242 0.3053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0247 0.6316 0.86
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Loa Loa (eye worm) hypothetical protein 0.013 0.2678 0.3647
Echinococcus granulosus thyroid hormone receptor alpha 0.0116 0.2242 0.355
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.4752 0.6471
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0116 0.2242 0.3053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0247 0.6316 0.86
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0247 0.6316 0.86
Brugia malayi hypothetical protein 0.013 0.2678 0.3647
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Echinococcus granulosus Nuclear hormone receptor HR96 0.0116 0.2242 0.355
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.7344 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0247 0.6316 0.86
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3998 0.3998
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0247 0.6316 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0116 0.2242 0.3053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0247 0.6316 0.86
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0116 0.2242 0.355
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0116 0.2242 0.355
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0247 0.6316 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.013 0.2678 0.3647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0247 0.6316 0.86
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0116 0.2242 0.355
Brugia malayi hypothetical protein 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.0247 0.6316 0.86
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0247 0.6316 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0247 0.6316 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0247 0.6316 1
Brugia malayi Nuclear hormone receptor-like 1 0.0247 0.6316 0.86
Brugia malayi Nuclear hormone receptor E75 0.0116 0.2242 0.3053
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0558 0.0558
Brugia malayi Steroid receptor seven-up type 2 0.0247 0.6316 0.86
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0247 0.6316 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0247 0.6316 0.86
Loa Loa (eye worm) DR-78 0.0116 0.2242 0.3053
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4752 0.7524
Loa Loa (eye worm) hypothetical protein 0.0116 0.2242 0.3053
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.4752 0.6471

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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