Detailed information for compound 1268384

Basic information

Technical information
  • TDR Targets ID: 1268384
  • Name: N-[4-(4-chloro-2-nitrophenyl)piperazine-1-car bothioyl]furan-2-carboxamide
  • MW: 394.833 | Formula: C16H15ClN4O4S
  • H donors: 1 H acceptors: 3 LogP: 3.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)[N+](=O)[O-])N1CCN(CC1)C(=S)NC(=O)c1ccco1
  • InChi: 1S/C16H15ClN4O4S/c17-11-3-4-12(13(10-11)21(23)24)19-5-7-20(8-6-19)16(26)18-15(22)14-2-1-9-25-14/h1-4,9-10H,5-8H2,(H,18,22,26)
  • InChiKey: RZFABKMBMDAVGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(4-chloro-2-nitro-phenyl)piperazine-1-carbothioyl]furan-2-carboxamide
  • N-[[4-(4-chloro-2-nitrophenyl)-1-piperazinyl]-thioxomethyl]-2-furancarboxamide
  • N-[4-(4-chloro-2-nitro-phenyl)piperazine-1-carbothioyl]-2-furamide
  • N-[4-(4-chloro-2-nitro-phenyl)piperazin-1-yl]carbothioylfuran-2-carboxamide
  • STOCK2S-68529
  • Oprea1_342883
  • MLS000666510
  • N-{[4-(4-chloro-2-nitrophenyl)-1-piperazinyl]carbonothioyl}-2-furamide
  • SMR000268847
  • ZINC04834757

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0036 0.1277 0.0833
Schistosoma mansoni opsin-like receptor 0.0036 0.1277 0.0833
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.1277 0.1153
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.1277 0.1245
Echinococcus granulosus tar DNA binding protein 0.0076 0.3714 0.3691
Schistosoma mansoni amine GPCR 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.1277 0.1245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.1277 0.0833
Schistosoma mansoni histamine h1 receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis g protein coupled receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Brugia malayi neuropeptide F receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.1277 0.1277
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.1277 0.1245
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.1277 0.1245
Echinococcus granulosus lamin 0.0033 0.1056 0.1023
Schistosoma mansoni opsin-like receptor 0.0036 0.1277 0.0833
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.1277 0.0833
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1056 0.0928
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.1277 0.1245
Brugia malayi RNA binding protein 0.0076 0.3714 0.3624
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Loa Loa (eye worm) RNA binding protein 0.0076 0.3714 0.3714
Echinococcus granulosus somatostatin receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.1277 0.1245
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.1277 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3714 1
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.1277 0.1277
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.1277 0.1245
Schistosoma mansoni neuropeptide receptor 0.0036 0.1277 0.0833
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus multilocularis musashi 0.0033 0.1056 0.1023
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1056 0.1056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0033 0.1056 0.1056
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.1277 0.0833
Echinococcus granulosus neuropeptide receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.1277 0.1245
Onchocerca volvulus 0.0036 0.1277 1
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus granulosus intermediate filament protein 0.0033 0.1056 0.1023
Brugia malayi neuropeptide F receptor 0.0036 0.1277 0.1153
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus granulosus neuropeptide s receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni hypothetical protein 0.0036 0.1277 0.0833
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.1277 0.1245
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.1277 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3714 1
Echinococcus multilocularis muscleblind protein 1 0.018 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.1277 0.1245
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.1277 0.1245
Echinococcus multilocularis fmrfamide receptor 0.0036 0.1277 0.1245
Schistosoma mansoni hypothetical protein 0.0036 0.1277 0.0833
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.1277 0.1245
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.1277 0.1245
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.1277 0.0833
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.1277 0.1153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.1277 0.1245
Brugia malayi intermediate filament protein 0.0033 0.1056 0.0928
Loa Loa (eye worm) hypothetical protein 0.0032 0.102 0.102
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.1277 0.1277
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Brugia malayi Melatonin receptor type 1A 0.0036 0.1277 0.1153
Echinococcus multilocularis g protein coupled receptor 0.0036 0.1277 0.1245
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.1277 0.1245
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.1277 0.1245
Schistosoma mansoni hypothetical protein 0.0036 0.1277 0.0833
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Onchocerca volvulus 0.0036 0.1277 1
Brugia malayi Dopamine receptor 0.0036 0.1277 0.1153
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus lamin dm0 0.0033 0.1056 0.1023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis orexin receptor type 2 0.0036 0.1277 0.1245
Schistosoma mansoni amine GPCR 0.0036 0.1277 0.0833
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus neuropeptide receptor 0.0036 0.1277 0.1245
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.1277 0.0833
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Onchocerca volvulus 0.0036 0.1277 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.1277 0.1277
Brugia malayi sulfakinin receptor protein 0.0036 0.1277 0.1153
Brugia malayi follicle stimulating hormone receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3714 0.3714
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.1277 0.1277
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.1277 0.1245
Echinococcus multilocularis neuropeptide receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus g protein coupled receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.1277 0.1245
Schistosoma mansoni adenoreceptor 0.0036 0.1277 0.0833
Echinococcus granulosus g protein coupled receptor 0.0036 0.1277 0.1245
Schistosoma mansoni neuropeptide receptor 0.0036 0.1277 0.0833
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.1277 0.1245
Echinococcus granulosus fmrfamide receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis serotonin receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3714 0.3691
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.1277 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.1277 0.0833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.1277 0.1153
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.1277 0.1245
Echinococcus granulosus serotonin receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.1277 0.1245
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.1277 0.1245
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.1277 0.1245
Brugia malayi putative neuropeptide receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.1277 0.1245
Schistosoma mansoni neuropeptide receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Onchocerca volvulus 0.0036 0.1277 1
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.1277 0.1277
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.1277 0.1245
Schistosoma mansoni amine GPCR 0.0036 0.1277 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Schistosoma mansoni biogenic amine receptor 0.0036 0.1277 0.0833
Brugia malayi ORL1-like opioid receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis allatostatin A receptor 0.0036 0.1277 0.1245
Schistosoma mansoni amine GPCR 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.1277 0.0833
Brugia malayi RE15519p 0.0036 0.1277 0.1153
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.1277 0.1245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Brugia malayi G-protein coupled receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Brugia malayi Serotonin receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis fmrfamide receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis g protein coupled receptor 0.0036 0.1277 0.1245
Schistosoma mansoni neuropeptide receptor 0.0036 0.1277 0.0833
Brugia malayi TAR-binding protein 0.0076 0.3714 0.3624
Brugia malayi G-protein coupled receptor 0.0036 0.1277 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.1277 0.0833
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.1277 0.1277
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus multilocularis lamin dm0 0.0033 0.1056 0.1023
Brugia malayi AKH receptor 0.0036 0.1277 0.1153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Echinococcus granulosus g-protein coupled receptor 0.0036 0.1277 0.1245
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.1277 0.0833
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.1277 0.0833
Schistosoma mansoni biogenic amine receptor 0.0036 0.1277 0.0833
Onchocerca volvulus 0.0036 0.1277 1
Onchocerca volvulus 0.0036 0.1277 1
Brugia malayi G protein-coupled receptor 0.0036 0.1277 0.1153
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.1277 0.1277
Echinococcus multilocularis serotonin receptor 0.0036 0.1277 0.1245
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.1277 0.0833
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3714 0.3714
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3714 0.3624
Echinococcus multilocularis sex peptide receptor 0.0036 0.1277 0.1245
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.1277 0.1245
Brugia malayi larval opioid receptor 0.0036 0.1277 0.1153
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.1277 0.1153
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.1277 0.1245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Brugia malayi GnHR receptor homolog 0.0036 0.1277 0.1153
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3714 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Echinococcus granulosus sex peptide receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.1277 0.1245
Echinococcus granulosus muscleblind protein 0.018 1 1
Onchocerca volvulus 0.0036 0.1277 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.1277 0.1245
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Echinococcus granulosus g protein coupled receptor 0.0036 0.1277 0.1245
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.1277 0.1245
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.1277 0.1245
Schistosoma mansoni hypothetical protein 0.0036 0.1277 0.0833
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.1277 0.1277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Echinococcus multilocularis lamin 0.0033 0.1056 0.1023
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.1277 0.1245
Onchocerca volvulus 0.0036 0.1277 1
Brugia malayi Serotonin receptor 0.0036 0.1277 0.1153
Echinococcus multilocularis neuropeptide receptor 0.0036 0.1277 0.1245
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.1277 0.1153
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.1277 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.1277 0.1153
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3714 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3714 1
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.1277 0.1245
Echinococcus granulosus orexin receptor type 2 0.0036 0.1277 0.1245
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.1277 0.0833
Schistosoma mansoni biogenic amine receptor 0.0036 0.1277 0.0833
Echinococcus multilocularis somatostatin receptor 0.0036 0.1277 0.1245
Brugia malayi Dopamine receptor protein 2 0.0036 0.1277 0.1153
Schistosoma mansoni myosin xvIII 0.0036 0.1277 0.0833
Echinococcus multilocularis muscleblind protein 0.018 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.1277 0.1245
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.1277 0.1245
Echinococcus granulosus hypothetical protein 0.0036 0.1277 0.1245
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.1277 0.1245
Echinococcus granulosus allatostatin A receptor 0.0036 0.1277 0.1245
Schistosoma mansoni opsin-like receptor 0.0036 0.1277 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Brugia malayi hypothetical protein 0.0036 0.1277 0.1153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0141 0.0141
Brugia malayi Dopamine receptor protein 1 0.0036 0.1277 0.1153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833
Onchocerca volvulus 0.0036 0.1277 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1277 0.1277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.1277 0.0833

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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