Detailed information for compound 1268393

Basic information

Technical information
  • TDR Targets ID: 1268393
  • Name: 3-(4-methylphenyl)sulfonyl-1,3-thiazolidine-2 -carboxylic acid
  • MW: 287.355 | Formula: C11H13NO4S2
  • H donors: 1 H acceptors: 4 LogP: 1.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1SCCN1S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C11H13NO4S2/c1-8-2-4-9(5-3-8)18(15,16)12-6-7-17-10(12)11(13)14/h2-5,10H,6-7H2,1H3,(H,13,14)
  • InChiKey: QMMCDUMVSRECJR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methylphenyl)sulfonylthiazolidine-2-carboxylic acid
  • 3-(4-methylphenyl)sulfonyl-2-thiazolidinecarboxylic acid
  • Oprea1_265525
  • 3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic acid
  • ST5235586
  • BAS 00608459
  • MLS000035478
  • SMR000123021
  • Oprea1_421933

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii V-ATPase subunit c' proteolipid, putative 0.0044 0.0005 0.002
Trypanosoma cruzi ATPase subunit 9, putative 0.0348 0.047 1
Loa Loa (eye worm) vacuolar H ATPase family member 0.0087 0.0072 0.2017
Trypanosoma brucei V-type ATPase, A subunit, putative 0.0087 0.0072 0.1442
Trypanosoma brucei Mitochondrial ATP synthase subunit c-2 0.0348 0.047 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0026 0.0556
Trypanosoma cruzi ATPase subunit 9, putative 0.0348 0.047 1
Echinococcus multilocularis ATP synthase subunit beta, mitochondrial 0.0149 0.0166 0.354
Brugia malayi beta-lactamase family protein 0.0043 0.0005 0.0096
Trypanosoma brucei ATP synthase F1 subunit gamma protein, putative 0.0217 0.027 0.571
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0087 0.0072 0.1442
Echinococcus multilocularis H+ transporting ATP synthase O subunit 0.0051 0.0017 0.0357
Mycobacterium leprae PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG 0.0217 0.027 0.0268
Onchocerca volvulus ATP synthase subunit delta, mitochondrial homolog 0.0273 0.0355 0.8223
Brugia malayi hypothetical protein 0.0051 0.0017 0.0357
Mycobacterium leprae PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) 0.0348 0.047 0.0469
Brugia malayi ATP synthase beta chain, mitochondrial precursor, putative 0.0149 0.0166 0.354
Mycobacterium ulcerans F0F1 ATP synthase subunit epsilon 0.0273 0.0355 0.0353
Leishmania major ATPase subunit 9, putative 0.0348 0.047 1
Mycobacterium tuberculosis Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) 0.0348 0.047 0.0465
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0285 0.6072
Loa Loa (eye worm) vacuolar ATP synthase proteolipid subunit 0.0044 0.0005 0.0153
Entamoeba histolytica V-type ATPase, A subunit, putative 0.0087 0.0072 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0026 0.0336
Chlamydia trachomatis V-type ATP synthase subunit A 0.0087 0.0072 0.4114
Mycobacterium ulcerans F0F1 ATP synthase subunit A 0.0769 0.1115 0.1119
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0322 0.0431 1
Trypanosoma cruzi ATP synthase F1 subunit gamma protein, putative 0.0217 0.027 0.571
Trypanosoma brucei mitochondrial ATP synthase delta chain 0.0273 0.0355 0.7535
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0058 0.0026 0.0736
Echinococcus multilocularis ATP synthase gamma subunit 0.0217 0.027 0.5751
Trypanosoma cruzi vacuolar type h+ ATPase subunit, putative 0.0044 0.0005 0.002
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit B 0.1323 0.1962 1
Trypanosoma cruzi vacuolar type h+ ATPase subunit, putative 0.0044 0.0005 0.002
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.0087 0.0072 0.1442
Loa Loa (eye worm) vacuolar ATP synthase proteolipid subunit 1 0.0044 0.0005 0.0153
Trichomonas vaginalis ATP synthase, putative 0.005 0.0014 0.1475
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0322 0.0431 0.9172
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0026 0.0336
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0322 0.0431 0.9172
Giardia lamblia Vacuolar ATP synthase catalytic subunit A 0.0087 0.0072 1
Trypanosoma cruzi vacuolar ATP synthase, putative 0.0044 0.0005 0.002
Schistosoma mansoni ATP synthase gamma subunit 0.0217 0.027 0.413
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.0044 0.0005 0.0139
Trypanosoma cruzi vacuolar ATP synthase, putative 0.0044 0.0005 0.002
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.0087 0.0072 0.1442
Schistosoma mansoni ATP synthase gamma subunit 0.0217 0.027 0.413
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0322 0.0431 0.0426
Trichomonas vaginalis ATP synthase beta subunit, putative 0.0087 0.0072 1
Brugia malayi vacuolar ATP synthase subunit B 0.0087 0.0072 0.1525
Echinococcus granulosus vacuolar H ATPase v1 sector subunit A 0.0087 0.0072 0.1525
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit beta 0.0149 0.0166 0.0768
Echinococcus multilocularis Vacuolar ATP synthase 16 kDa proteolipid 0.0044 0.0005 0.0116
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit C 0.0348 0.047 0.2328
Leishmania major ATPase beta subunit, putative 0.0149 0.0166 0.3477
Plasmodium vivax ATP synthase delta chain, mitochondrial, putative 0.0051 0.0017 0.0264
Echinococcus multilocularis ATP synthase subunit delta, mitochondrial 0.0273 0.0355 0.7559
Trypanosoma cruzi ATP synthase, epsilon chain, putative 0.0273 0.0355 0.7535
Brugia malayi Vacuolar ATP synthase 16 kDa proteolipid subunit, putative 0.0044 0.0005 0.0116
Mycobacterium leprae PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA 0.0322 0.0431 0.043
Plasmodium vivax ATP synthase alpha chain, putative 0.0322 0.0431 0.9164
Entamoeba histolytica V-type ATPase, B subunit, putative 0.0087 0.0072 1
Onchocerca volvulus ATP synthase subunit gamma, mitochondrial homolog 0.0217 0.027 0.6231
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.0087 0.0072 0.1442
Schistosoma mansoni ATP synthase gamma subunit 0.0217 0.027 0.413
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0038 0.0816
Leishmania major ATP synthase, epsilon chain, putative 0.0273 0.0355 0.7535
Mycobacterium tuberculosis Probable ATP synthase gamma chain AtpG 0.0217 0.027 0.0266
Plasmodium vivax ATP synthase lipid-binding protein, mitochondrial precursor, putative 0.0348 0.047 1
Treponema pallidum flagellum-specific ATP synthase (fliI) 0.0149 0.0166 1
Treponema pallidum V-type ATP synthase subunit A 0.0087 0.0072 0.4114
Trypanosoma cruzi ATPase subunit 9, putative 0.0348 0.047 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0363 0.0359
Chlamydia trachomatis V-type ATP synthase subunit B 0.0087 0.0072 0.4114
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.0087 0.0072 0.1442
Schistosoma mansoni vacuolar ATP synthase proteolipid subunit 1 2 3 0.0044 0.0005 0.0014
Brugia malayi vacuolar ATP synthase catalytic subunit A, osteoclast isoform 0.0087 0.0072 0.1525
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative 0.0044 0.0005 0.0139
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0344 0.0464 0.046
Leishmania major V-type ATPase, C subunit, putative 0.0044 0.0005 0.002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0285 0.6072
Schistosoma mansoni ATP synthase lipid-binding protein-like protein 0.0348 0.047 0.7232
Plasmodium falciparum ATP synthase subunit O, mitochondrial, putative 0.0051 0.0017 0.0244
Toxoplasma gondii ATP synthase F1 gamma subunit 0.0217 0.027 0.571
Treponema pallidum V-type ATP synthase subunit A 0.0087 0.0072 0.4114
Trypanosoma cruzi ATPase subunit 9, putative 0.0348 0.047 1
Mycobacterium ulcerans F0F1 ATP synthase subunit delta 0.1375 0.2041 0.2054
Brugia malayi mbt repeat family protein 0.0058 0.0026 0.0556
Mycobacterium ulcerans F0F1 ATP synthase subunit gamma 0.0217 0.027 0.0268
Schistosoma mansoni ATP synthase gamma subunit 0.0217 0.027 0.413
Entamoeba histolytica vacuolar ATP synthase subunit B, putative 0.005 0.0014 0.1355
Mycobacterium leprae PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) 0.0769 0.1115 0.1119
Leishmania major vacuolar type h ATPase subunit, putative 0.0044 0.0005 0.002
Echinococcus granulosus Vacuolar ATP synthase 16 kDa proteolipid 0.0044 0.0005 0.0116
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0038 0.0816
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0005 0.0096
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0038 0.0816
Trypanosoma brucei hypothetical protein 0.0304 0.0402 0.855
Leishmania major ATPase alpha subunit 0.0272 0.0354 0.7521
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0026 0.0556
Trypanosoma brucei vacuolar ATP synthase, putative 0.0044 0.0005 0.002
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0322 0.0431 0.6627
Onchocerca volvulus 0.0058 0.0026 0.0507
Schistosoma mansoni ATP synthase beta subunit 0.0149 0.0166 0.2515
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.0087 0.0072 0.1442
Plasmodium vivax V-type proton ATPase 16 kDa proteolipid subunit, putative 0.0044 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.1079
Schistosoma mansoni ATP synthase F0 subunit 6 0.0464 0.0648 1
Mycobacterium leprae PROBABLE ATP SYNTHASE BETA CHAIN ATPD 0.0344 0.0464 0.0463
Schistosoma mansoni ATP synthase alpha subunit vacuolar 0.0087 0.0072 0.1043
Brugia malayi beta-lactamase 0.0043 0.0005 0.0096
Schistosoma mansoni ATP synthase delta chain mitochondrial 0.0273 0.0355 0.5449
Loa Loa (eye worm) ATP synthase subunit delta 0.0273 0.0355 1
Schistosoma mansoni vacuolar ATP synthase proteolipid subunit 1 2 3 0.0044 0.0005 0.0014
Mycobacterium ulcerans F0F1 ATP synthase subunit beta 0.0149 0.0166 0.0163
Schistosoma mansoni hypothetical protein 0.035 0.0474 0.7293
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0006 0.0018
Plasmodium vivax V-type proton ATPase 21 kDa proteolipid subunit, putative 0.0044 0.0005 0.002
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0038 0.0816
Mycobacterium ulcerans F0F1 ATP synthase subunit alpha 0.0322 0.0431 0.043
Schistosoma mansoni ATP synthase lipid-binding protein-like protein 0.0348 0.047 0.7232
Toxoplasma gondii ATP synthase F0 subunit 9, putative 0.0348 0.047 1
Leishmania major hypothetical protein, conserved 0.0051 0.0017 0.0264
Brugia malayi ATP synthase delta chain, mitochondrial precursor, putative 0.0273 0.0355 0.7559
Brugia malayi Vacuolar ATP synthase 21 kDa proteolipid subunit, putative 0.0044 0.0005 0.0116
Loa Loa (eye worm) MBCTL1 0.0066 0.0038 0.1079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0005 0.0096
Echinococcus granulosus V type proton ATPase 21 kDa proteolipid subunit 0.0044 0.0005 0.0116
Trypanosoma brucei V-type ATPase, C subunit, putative 0.0044 0.0005 0.002
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.0044 0.0005 0.0139
Loa Loa (eye worm) vacuolar ATP synthase proteolipid subunit 0.0044 0.0005 0.0153
Brugia malayi Vacuolar ATP synthase 16 kDa proteolipid subunit 1, putative 0.0044 0.0005 0.0116
Plasmodium vivax vacuolar ATP synthase catalytic subunit A, putative 0.0087 0.0072 0.1442
Echinococcus granulosus ATP synthase subunit beta mitochondrial 0.0149 0.0166 0.354
Leishmania major vacuolar ATP synthase subunit b, putative 0.0087 0.0072 0.1442
Trypanosoma cruzi V-type ATPase, C subunit, putative 0.0044 0.0005 0.002
Leishmania major ATPase subunit 9, putative 0.0348 0.047 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0026 0.0336
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Brugia malayi ATP synthase F1, delta subunit family protein 0.0051 0.0017 0.0357
Trypanosoma brucei ATP synthase subunit beta, mitochondrial 0.0149 0.0166 0.3477
Chlamydia trachomatis type III secretion system ATPase 0.0149 0.0166 1
Trypanosoma brucei vacuolar type h+ ATPase subunit, putative 0.0044 0.0005 0.002
Leishmania major ATP synthase F1 subunit gamma protein, putative 0.0217 0.027 0.571
Mycobacterium tuberculosis Probable ATP synthase B chain AtpF 0.6527 0.9921 0.9921
Echinococcus granulosus 5'partial|ATP synthase subunit delta mitochondrial 0.0273 0.0355 0.7559
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0017 0.0264
Leishmania major ATPase subunit 9, putative 0.0348 0.047 1
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.0087 0.0072 0.1043
Loa Loa (eye worm) hypothetical protein 0.0217 0.027 0.7609
Plasmodium falciparum V-type proton ATPase catalytic subunit A 0.0087 0.0072 0.1425
Brugia malayi beta-lactamase family protein 0.0043 0.0005 0.0096
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0087 0.0072 0.1442
Leishmania major ATPase beta subunit, putative 0.0149 0.0166 0.3477
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0006 0.0018
Plasmodium falciparum ATP synthase subunit delta, mitochondrial, putative 0.0273 0.0355 0.753
Mycobacterium leprae PROBABLE ATP SYNTHASE B CHAIN ATPF 0.6527 0.9921 1
Trichomonas vaginalis ATP synthase, putative 0.0087 0.0072 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.0087 0.0072 1
Trypanosoma cruzi ATP synthase subunit beta, mitochondrial, putative 0.0149 0.0166 0.3477
Trypanosoma brucei Mitochondrial ATP synthase subunit 5 0.0051 0.0017 0.0264
Mycobacterium ulcerans F0F1 ATP synthase subunit B 0.6527 0.9921 1
Plasmodium falciparum V-type proton ATPase subunit B 0.0087 0.0072 0.1425
Mycobacterium tuberculosis Probable ATP synthase epsilon chain AtpC 0.0273 0.0355 0.0351
Echinococcus multilocularis V type proton ATPase 21 kDa proteolipid subunit 0.0044 0.0005 0.0116
Treponema pallidum V-type ATP synthase subunit B 0.0087 0.0072 0.4114
Schistosoma mansoni vacuolar ATP synthase proteolipid subunit 0.0044 0.0005 0.0014
Plasmodium falciparum ATP synthase subunit C, putative 0.0348 0.047 1
Toxoplasma gondii ATP synthase beta subunit ATP-B 0.0149 0.0166 0.3477
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) 0.0769 0.1115 0.111
Echinococcus granulosus mitochondrial ATP synthase subunit 9 0.0348 0.047 1
Trypanosoma cruzi ATP synthase F1 subunit gamma protein, putative 0.0217 0.027 0.571
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit alpha 0.0322 0.0431 0.2128
Brugia malayi ATP synthase gamma chain, mitochondrial precursor, putative 0.0217 0.027 0.5751
Toxoplasma gondii ATP synthase, putative 0.0273 0.0355 0.7535
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0026 0.0556
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0005 0.0127
Echinococcus multilocularis vacuolar H+ ATPase v1 sector subunit A 0.0087 0.0072 0.1525
Echinococcus granulosus Vacuolar ATP synthase 16 kDa proteolipid 0.0044 0.0005 0.0116
Loa Loa (eye worm) beta-lactamase 0.0043 0.0005 0.0127
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit gamma 0.0217 0.027 0.1302
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit epsilon 0.0273 0.0355 0.1739
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Trypanosoma brucei Mitochondrial ATP synthase subunit c-3 0.0348 0.047 1
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.0087 0.0072 0.2017
Plasmodium falciparum ATP synthase F1, alpha subunit 0.0322 0.0431 0.9162
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative 0.0044 0.0005 0.0139
Giardia lamblia Vacuolar ATP synthase subunit B 0.0087 0.0072 1
Loa Loa (eye worm) ATP synthase F1 0.0051 0.0017 0.0473
Mycobacterium leprae PROBABLE ATP SYNTHASE DELTA CHAIN ATPH 0.1375 0.2041 0.2054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Loa Loa (eye worm) hypothetical protein 0.0051 0.0017 0.0473
Echinococcus granulosus vacuolar ATP synthase subunit b 0.0087 0.0072 0.1525
Echinococcus multilocularis Vacuolar ATP synthase 16 kDa proteolipid 0.0044 0.0005 0.0116
Plasmodium vivax ATP synthase subunit beta, mitochondrial, putative 0.0149 0.0166 0.3477
Brugia malayi ATP synthase lipid-binding protein, mitochondrial precursor 0.0348 0.047 1
Brugia malayi mbt repeat family protein 0.0058 0.0026 0.0556
Schistosoma mansoni ATP synthase delta chain 0.0051 0.0017 0.0191
Trypanosoma brucei vacuolar ATP synthase 16 kDa proteolipid subunit, putative 0.0044 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0038 0.0525
Toxoplasma gondii ATP synthase F1, delta subunit protein 0.0051 0.0017 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0273 0.0355 0.7535
Trypanosoma brucei Mitochondrial ATP synthase subunit c-1 0.0348 0.047 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0026 0.0507
Schistosoma mansoni ATP synthase gamma subunit 0.0217 0.027 0.413
Leishmania major vacuolar ATP synthase catalytic subunit A, putative 0.0087 0.0072 0.1442
Plasmodium vivax ATP synthase subunit gamma, mitochondrial, putative 0.0217 0.027 0.571
Loa Loa (eye worm) ATP synthase subunit beta 0.0099 0.009 0.2532
Chlamydia trachomatis type III secretion system ATP synthase 0.0087 0.0072 0.4114
Echinococcus granulosus ATP synthase gamma subunit 0.0217 0.027 0.5751
Echinococcus granulosus H transporting ATP synthase O subunit 0.0051 0.0017 0.0357
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0026 0.0556
Mycobacterium ulcerans F0F1 ATP synthase subunit C 0.0348 0.047 0.0469
Plasmodium falciparum ATP synthase subunit gamma, mitochondrial 0.0217 0.027 0.5702
Mycobacterium leprae PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC 0.0273 0.0355 0.0353
Toxoplasma gondii vacuolar ATP synthase subunit A, putative 0.0087 0.0072 0.1442
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0038 0.0816
Leishmania major vacuolar type h ATPase subunit, putative 0.0044 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0127
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit A 0.0769 0.1115 0.5642
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.0044 0.0005 0.0139
Trypanosoma cruzi vacuolar type h+ ATPase subunit, putative 0.0044 0.0005 0.002
Leishmania major ATPase alpha subunit 0.0272 0.0354 0.7521
Trypanosoma cruzi vacuolar type h+ ATPase subunit, putative 0.0044 0.0005 0.002
Leishmania major vacuolar ATP synthase, putative 0.0044 0.0005 0.002
Trypanosoma cruzi ATPase subunit 9, putative 0.0348 0.047 1
Echinococcus multilocularis mitochondrial ATP synthase subunit 9 0.0348 0.047 1
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0272 0.0354 0.7521
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.0087 0.0072 0.1525
Plasmodium falciparum ATP synthase subunit beta, mitochondrial 0.0149 0.0166 0.3464
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0322 0.0431 0.9172
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0272 0.0354 0.7521
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0026 0.0736
Leishmania major vacuolar ATP synthase, putative 0.0044 0.0005 0.002
Treponema pallidum V-type ATP synthase subunit B 0.0087 0.0072 0.4114

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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