Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0876 | 0.1029 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0418 | 0.8514 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0876 | 0.0876 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0876 | 0.1029 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0288 | 0.5783 | 0.5783 |
Schistosoma mansoni | tyrosine kinase | 0.0288 | 0.5783 | 0.6793 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0418 | 0.8514 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0418 | 0.8514 | 1 |
Brugia malayi | Doublecortin family protein | 0.0122 | 0.2277 | 0.2178 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0418 | 0.8514 | 0.8514 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0488 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0075 | 0.1289 | 0.1178 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0418 | 0.8514 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0876 | 0.0876 |
Brugia malayi | MAP kinase sur-1 | 0.0418 | 0.8514 | 0.8495 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0075 | 0.1289 | 0.1289 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0075 | 0.1289 | 0.1515 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0288 | 0.5783 | 0.5783 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0354 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0418 | 0.8514 | 1 |
Loa Loa (eye worm) | camk/dcamkl protein kinase | 0.0122 | 0.2277 | 0.1993 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0418 | 0.8514 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0418 | 0.8514 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0876 | 0.0876 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0418 | 0.8514 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0418 | 0.8514 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0418 | 0.8514 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.5783 | 0.5629 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0488 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0876 | 0.0759 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0876 | 0.1029 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0418 | 0.8514 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.5703 | 0.5546 |
Brugia malayi | hypothetical protein | 0.003 | 0.0354 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.5703 | 0.5546 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0418 | 0.8514 | 0.8514 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0418 | 0.8514 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0418 | 0.8514 | 0.8459 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0418 | 0.8514 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0418 | 0.8514 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0418 | 0.8514 | 0.8514 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.992 | 0.9917 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 1 | 1 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0075 | 0.1289 | 0.097 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0418 | 0.8514 | 0.8514 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0488 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0354 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0876 | 0.0541 |
Echinococcus multilocularis | transfer RNA-Thr | 0.0488 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0354 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0418 | 0.8514 | 1 |
Echinococcus granulosus | cyclin g associated kinase | 0.0075 | 0.1289 | 0.1289 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1049 | 0.0721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.