Detailed information for compound 1269124

Basic information

Technical information
  • TDR Targets ID: 1269124
  • Name: (7-bromo-4-oxopyrido[1,2-a]pyrimidin-2-yl)met hyl 2-[(3-fluorobenzoyl)amino]acetate
  • MW: 434.216 | Formula: C18H13BrFN3O4
  • H donors: 1 H acceptors: 3 LogP: 1.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OCc1cc(=O)n2c(n1)ccc(c2)Br)CNC(=O)c1cccc(c1)F
  • InChi: 1S/C18H13BrFN3O4/c19-12-4-5-15-22-14(7-16(24)23(15)9-12)10-27-17(25)8-21-18(26)11-2-1-3-13(20)6-11/h1-7,9H,8,10H2,(H,21,26)
  • InChiKey: ISTYCRNVMYLXDK-UHFFFAOYSA-N  


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Synonyms

  • (7-bromo-4-oxo-pyrido[1,2-a]pyrimidin-2-yl)methyl 2-[(3-fluorobenzoyl)amino]acetate
  • 2-[[(3-fluorophenyl)-oxomethyl]amino]acetic acid (7-bromo-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl ester
  • 2-[(3-fluorobenzoyl)amino]acetic acid (7-bromo-4-keto-pyrido[1,2-a]pyrimidin-2-yl)methyl ester
  • (7-bromo-4-oxo-pyrido[1,2-a]pyrimidin-2-yl)methyl 2-[(3-fluorophenyl)carbonylamino]ethanoate
  • MLS000335542
  • SMR000253296
  • T0520-1554

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1126 1
Brugia malayi Heterochromatin protein 1 0.0068 0.1663 0.2019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0477 0.1039
Loa Loa (eye worm) hypothetical protein 0.003 0.0531 0.0483
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0477 0.2273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.7114 0.7106
Mycobacterium tuberculosis Conserved protein 0.0038 0.0749 0.0859
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0477 0.0409
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1126 0.1103
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1502 0.148
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0749 0.0859
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1502 0.1985
Trichomonas vaginalis chromobox protein, putative 0.0041 0.085 0.4538
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0749 0.3858
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0749 0.0859
Onchocerca volvulus 0.0038 0.0749 0.881
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1126 0.1103
Brugia malayi follicle stimulating hormone receptor 0.0263 0.7546 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.7114 0.7106
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1502 0.148
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0749 0.0725
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Onchocerca volvulus 0.0029 0.0477 0.5605
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0531 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1502 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0224 0.0073
Brugia malayi MAP kinase sur-1 0.005 0.1126 0.129
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1126 0.7165
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0749 0.6038
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0749 0.6038
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0477 0.2273
Mycobacterium tuberculosis Conserved protein 0.0038 0.0749 0.0859
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0477 0.0409
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0477 0.2273
Mycobacterium ulcerans hypothetical protein 0.0038 0.0749 0.4326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0224 0.0073
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0531 0.3745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0224 0.0073
Mycobacterium ulcerans beta-lactamase 0.0038 0.0749 0.4326
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1126 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.0114
Brugia malayi beta-lactamase family protein 0.0038 0.0749 0.0779
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0477 0.2273
Schistosoma mansoni ap endonuclease 0.0019 0.0175 0.015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.6862 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0749 0.0859
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0477 0.2273
Trichomonas vaginalis chromobox protein, putative 0.0041 0.085 0.4538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0409
Trypanosoma brucei protein kinase, putative 0.005 0.1126 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Onchocerca volvulus 0.0038 0.0749 0.881
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.0114
Entamoeba histolytica hypothetical protein 0.0115 0.308 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0249 0.7114 0.9413
Entamoeba histolytica hypothetical protein 0.0115 0.308 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1126 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1126 0.6389
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0763 0.8974
Schistosoma mansoni hypothetical protein 0.0345 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1126 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0477 0.2273
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0477 0.1039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.7114 0.7106
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0749 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0749 0.3858
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0763 0.3952
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.308 0.3062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.7114 0.7106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Mycobacterium ulcerans lipase LipD 0.0038 0.0749 0.4326
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1126 0.6389
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1502 1
Schistosoma mansoni hypothetical protein 0.0115 0.308 0.3062
Schistosoma mansoni chromobox protein 0.0068 0.1663 0.1642
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0259 0.5
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1126 0.7165
Brugia malayi beta-lactamase 0.0038 0.0749 0.0779
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1126 0.1103
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0477 0.2273
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0477 0.1039
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0749 0.0859
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0259 0.0125
Toxoplasma gondii ABC1 family protein 0.0038 0.0749 0.4326
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0749 0.0779
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1126 0.1103
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1126 0.129
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0477 0.0409
Leishmania major hypothetical protein, conserved 0.003 0.0531 0.2684
Mycobacterium ulcerans hypothetical protein 0.0029 0.0477 0.2273
Echinococcus multilocularis chromobox protein 1 0.0068 0.1663 0.1642
Schistosoma mansoni ap endonuclease 0.0019 0.0175 0.015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0749 0.0859
Onchocerca volvulus 0.0038 0.0749 0.881
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0749 0.4326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0224 0.0073
Echinococcus granulosus chromobox protein 1 0.0068 0.1663 0.1642
Brugia malayi beta-lactamase family protein 0.0038 0.0749 0.0779
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0749 0.0725
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0477 0.2273
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0749 0.3858
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0531 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0749 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1126 0.6389
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1502 1
Brugia malayi hypothetical protein 0.0115 0.308 0.3941
Loa Loa (eye worm) hypothetical protein 0.003 0.0515 0.0461
Echinococcus multilocularis geminin 0.0345 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0749 0.0779
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.308 0.3062
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0175 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1502 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0469 0.0399
Echinococcus granulosus chromobox protein 1 0.0068 0.1663 0.1642
Onchocerca volvulus 0.003 0.0515 0.6056
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0763 0.3952
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0749 0.3858
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0749 0.0725
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0749 0.0859
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0749 0.0859
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1663 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0259 0.1461
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0477 0.2273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.7114 0.7106
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1663 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0749 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0428 0.1699
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0749 0.0725
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1663 0.2019
Brugia malayi Cytochrome P450 family protein 0.0028 0.0469 0.0399
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.308 0.3062
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1126 0.7165
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1126 0.1103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0477 0.0451
Leishmania major hypothetical protein, conserved 0.0038 0.0749 0.4326
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0249 0.7114 0.9413
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0749 0.4326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.7114 0.7106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0409
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0259 0.0632
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0175 0.015
Entamoeba histolytica hypothetical protein 0.0115 0.308 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0259 0.2354
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0175 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1502 1
Schistosoma mansoni hypothetical protein 0.0345 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0531 0.6203
Brugia malayi hypothetical protein 0.002 0.0206 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0763 0.0798
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.0114
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.085 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0477 0.2273
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0175 0.015
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1126 0.6389
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0749 0.3858
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0749 0.0859
Loa Loa (eye worm) beta-lactamase 0.0038 0.0749 0.0779
Mycobacterium leprae Probable lipase LipE 0.0038 0.0749 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.7114 0.7106
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1502 0.148
Echinococcus multilocularis chromobox protein 1 0.0068 0.1663 0.1642
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0428 0.1699
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0531 0.2684
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.7546 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1502 0.148
Entamoeba histolytica hypothetical protein 0.0115 0.308 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0763 0.0798
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0531 0.3745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0477 0.0451
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0531 0.3745
Schistosoma mansoni chromobox protein 0.0068 0.1663 0.1642
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0749 0.6038
Trichomonas vaginalis esterase, putative 0.0038 0.0749 0.3858
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1126 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1126 1
Brugia malayi hypothetical protein 0.003 0.0531 0.0483

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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