Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
Potency (functional) | = 0.1259 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.