Detailed information for compound 1269712

Basic information

Technical information
  • TDR Targets ID: 1269712
  • Name: 2-[(2,5-dimethylphenyl)amino]-N,4-dimethyl-1, 3-thiazole-5-carboxamide
  • MW: 275.369 | Formula: C14H17N3OS
  • H donors: 2 H acceptors: 2 LogP: 3.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1sc(nc1C)Nc1cc(C)ccc1C
  • InChi: 1S/C14H17N3OS/c1-8-5-6-9(2)11(7-8)17-14-16-10(3)12(19-14)13(18)15-4/h5-7H,1-4H3,(H,15,18)(H,16,17)
  • InChiKey: ORLRJTPUVGRDCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,5-dimethylphenyl)amino]-N,4-dimethyl-thiazole-5-carboxamide
  • 2-[(2,5-dimethylphenyl)amino]-N,4-dimethyl-5-thiazolecarboxamide
  • MLS000771110
  • SMR000375980
  • T5323594
  • ZINC03458851

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.069 0.4393
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0605 0.7012 1
Schistosoma mansoni coup transcription factor 0.0038 0.0279 0.0344
Onchocerca volvulus 0.003 0.0186 0.0554
Loa Loa (eye worm) hypothetical protein 0.0096 0.0967 0.1152
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1552 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1552 1
Echinococcus multilocularis zinc finger transcription factor gli2 0.0315 0.3564 0.3539
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.069 0.1381
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0257 0.0307
Echinococcus multilocularis muscleblind protein 1 0.0456 0.5238 0.5219
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0279 0.0287
Trypanosoma brucei ISWI complex protein 0.0032 0.0207 0.2837
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0147 0.1573 0.1874
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.069 0.1381
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.004 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0559 0.3542
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2342 0.279
Echinococcus granulosus BC026374 protein S09 family 0.0102 0.104 0.1197
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.069 0.0273
Brugia malayi nuclear receptor RXR 0.002 0.0065 0.0078
Onchocerca volvulus 0.0038 0.0279 0.0905
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0186 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0279 0.0241
Onchocerca volvulus 0.0241 0.2689 1
Brugia malayi hypothetical protein 0.002 0.0065 0.0078
Echinococcus multilocularis protein patched 0.0041 0.0315 0.0277
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1209 0.1441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Schistosoma mansoni hypothetical protein 0.035 0.398 0.5652
Onchocerca volvulus Huntingtin homolog 0.0129 0.1363 0.4993
Brugia malayi hypoxia-induced factor 1 0.0152 0.1632 0.1944
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0279 0.0905
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0967 0.2275
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0559 0.0746
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0217
Echinococcus granulosus GPCR family 2 0.0031 0.0191 0.0181
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0102 0.104 0.1002
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Echinococcus granulosus neuroligin 0.0102 0.104 0.1197
Brugia malayi hypothetical protein 0.0165 0.1784 0.2125
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0065 0.0037
Brugia malayi steroid hormone receptor 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.069 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0279 0.0333
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0559 0.3542
Brugia malayi Carboxylesterase family protein 0.0102 0.104 0.1239
Brugia malayi Cytochrome P450 family protein 0.0016 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0151 0.018
Entamoeba histolytica hypothetical protein 0.0225 0.25 0.7227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0981 0.1169
Echinococcus multilocularis GPCR, family 2 0.0031 0.0191 0.0152
Brugia malayi Carboxylesterase family protein 0.0605 0.7012 0.8354
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1001 0.115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0251 0.0253
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0616 0.0733
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0279 0.0241
Echinococcus granulosus acetylcholinesterase 0.0605 0.7012 0.8346
Loa Loa (eye worm) hypothetical protein 0.009 0.0889 0.1059
Trypanosoma cruzi ISWI complex protein 0.0032 0.0207 0.2837
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.004 0.0047
Schistosoma mansoni hypothetical protein 0.004 0.0298 0.037
Brugia malayi ecdysteroid receptor 0.0038 0.0279 0.0333
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0279 0.0241
Schistosoma mansoni patched 1 0.0041 0.0315 0.0395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1001 0.0965
Loa Loa (eye worm) hypothetical protein 0.0105 0.1071 0.1276
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0279 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0078
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.3359 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.069 0.0273
Brugia malayi Carboxylesterase family protein 0.0102 0.104 0.1239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0279 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0279 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0279 0.0333
Echinococcus multilocularis lamin 0.0027 0.0151 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.1363 0.1623
Plasmodium vivax hypothetical protein, conserved 0.0073 0.069 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0279 0.0333
Entamoeba histolytica hypothetical protein 0.0225 0.25 0.7227
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0217
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0279 0.0344
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0315 0.033
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0387 0.0417
Loa Loa (eye worm) hypothetical protein 0.0605 0.7012 0.8354
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Brugia malayi Nuclear hormone receptor E75 0.0018 0.004 0.0047
Loa Loa (eye worm) acetylcholinesterase 1 0.0605 0.7012 0.8354
Brugia malayi MH2 domain containing protein 0.0117 0.1209 0.1441
Echinococcus granulosus zinc finger protein 0.0041 0.0313 0.0328
Brugia malayi Zinc finger, C2H2 type family protein 0.0315 0.3564 0.4247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0279 0.0287
Loa Loa (eye worm) hypothetical protein 0.0067 0.0616 0.0733
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0165 0.1784 0.2125
Schistosoma mansoni acetylcholinesterase 0.0102 0.104 0.1434
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0279 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.069 1
Schistosoma mansoni alpha-glucosidase 0.0143 0.1521 0.2125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.5351 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.069 0.1381
Trypanosoma brucei glucosidase, putative 0.0037 0.0262 0.3661
Echinococcus granulosus lamin 0.0027 0.0151 0.0134
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0102 0.104 0.1004
Brugia malayi hypothetical protein 0.0018 0.004 0.0047
Schistosoma mansoni bromodomain containing protein 0.0133 0.1403 0.1956
Schistosoma mansoni alpha-glucosidase 0.0143 0.1521 0.2125
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0279 0.0333
Schistosoma mansoni zinc finger protein 0.0032 0.0207 0.024
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.1632 0.1944
Schistosoma mansoni transcription factor LCR-F1 0.0225 0.25 0.3529
Brugia malayi Cytochrome P450 family protein 0.0016 0.0015 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.3359 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0191 0.0228
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0105 0.1077 0.1283
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0191 0.0181
Schistosoma mansoni survival motor neuron protein 0.0147 0.1573 0.2199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0279 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0279 0.0333
Brugia malayi CHE-14 protein 0.0041 0.0315 0.0376
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0387 0.0349
Echinococcus granulosus intermediate filament protein 0.0027 0.0151 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0279 0.0333
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0251 0.0303
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0315 0.0277
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0279 0.0344
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0559 0.8063
Onchocerca volvulus 0.0102 0.104 0.3774
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0173 0.016
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0191 0.0228
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0257 0.0219
Echinococcus granulosus acetylcholinesterase 0.0605 0.7012 0.8346
Entamoeba histolytica hypothetical protein 0.0225 0.25 0.7227
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0279 0.0344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1795 0.1763
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0186 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1001 0.0965
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1457 0.1696
Onchocerca volvulus 0.0073 0.069 0.2456
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0279 0.0344
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0279 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0173
Echinococcus multilocularis protein dispatched 1 0.0047 0.0384 0.0346
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0279 0.0333
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0279 0.0241
Brugia malayi hypothetical protein 0.0722 0.8393 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0387 0.0499
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0279 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0279 0.0333
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0279 0.0344
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0251 0.0303
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Entamoeba histolytica hypothetical protein 0.0225 0.25 0.7227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1001 0.115
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0266 0.0317
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0279 0.0344
Brugia malayi PHD-finger family protein 0.0052 0.0447 0.0532
Brugia malayi conserved hypotetical protein 0.0018 0.004 0.0047
Brugia malayi Bromodomain containing protein 0.008 0.078 0.093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.1314 0.1526
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0191 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.069 0.0933
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0559 0.3542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0279 0.0333
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0279 0.0241
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.3359 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0262 0.0267
Echinococcus granulosus muscleblind protein 0.0456 0.5238 0.6223
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.004 0.0047
Brugia malayi ecdysone receptor 0.0018 0.004 0.0047
Echinococcus granulosus single minded 2 0.0036 0.0257 0.0261
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0015 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1001 0.1378
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0315 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0279 0.0333
Leishmania major hypothetical protein, conserved 0.0073 0.069 1
Brugia malayi Carboxylesterase family protein 0.0102 0.104 0.1239
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0279 0.0344
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.069 0.0273
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0279 0.0287
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.004 0.0047
Onchocerca volvulus 0.0073 0.069 0.2456
Brugia malayi Pre-SET motif family protein 0.0212 0.2342 0.279
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0612 0.0685
Loa Loa (eye worm) hypothetical protein 0.0051 0.0425 0.0507
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0279 0.0241
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.018
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0262 0.1512
Echinococcus granulosus zinc finger transcription factor gli2 0.0315 0.3564 0.422
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.069 0.0273
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0279 0.0344
Loa Loa (eye worm) carboxylesterase 0.0102 0.104 0.1239
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0967 0.1152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.069 0.4393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1001 0.1378
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0129 0.1363 0.1623
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0041 0.0315 0.0376
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1795 0.1763
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Brugia malayi tailless protein 0.0018 0.004 0.0047
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.069 1
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.034 0.0405
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0721 0.0685
Loa Loa (eye worm) beta-lactamase 0.0073 0.069 0.0822
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0279 0.0287
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0102 0.104 0.251
Brugia malayi Muscleblind-like protein 0.0456 0.5238 0.624
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.069 0.0822
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0415 0.0539
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.069 0.4393
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0967 0.111
Echinococcus multilocularis survival motor neuron protein 1 0.0722 0.8393 0.8387
Echinococcus granulosus lamin dm0 0.0027 0.0151 0.0134
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1552 0.2071
Echinococcus multilocularis expressed conserved protein 0.009 0.0898 0.0861
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.004 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0279 0.0344
Echinococcus multilocularis para nitrobenzyl esterase 0.0102 0.104 0.1004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0279 0.0333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0015 0.0018
Brugia malayi hypothetical protein 0.002 0.0065 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0262 0.0313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0981 0.1169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0065 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0279 0.0344
Leishmania major hypothetical protein, conserved 0.0032 0.0207 0.2837
Brugia malayi Bromodomain containing protein 0.0157 0.1696 0.202
Loa Loa (eye worm) carboxylesterase 0.0102 0.104 0.1239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Echinococcus granulosus carboxylesterase 5A 0.0605 0.7012 0.8346
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.069 0.0779
Loa Loa (eye worm) hypothetical protein 0.0097 0.0981 0.1169
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.069 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0149 0.1589 0.1893
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0721 0.0816
Onchocerca volvulus 0.0027 0.0151 0.0422
Brugia malayi hypothetical protein 0.0225 0.25 0.2979
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Schistosoma mansoni BC026374 protein (S09 family) 0.0102 0.104 0.1434
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Schistosoma mansoni hypothetical protein 0.0225 0.25 0.3529
Onchocerca volvulus 0.0102 0.104 0.3774
Onchocerca volvulus Huntingtin homolog 0.0129 0.1363 0.4993
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0279 0.0287
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0225 0.25 0.2946
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0456 0.5238 0.624
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0279 0.0241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0191 0.0152
Brugia malayi beta-lactamase 0.0073 0.069 0.0822
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0065 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.1001 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0279 0.0333
Brugia malayi intermediate filament protein 0.0027 0.0151 0.018
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0251 0.0212
Brugia malayi nuclear hormone receptor 0.0038 0.0279 0.0333
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0315 0.033
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0279 0.0905
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Schistosoma mansoni intermediate filament proteins 0.0027 0.0151 0.016
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0559 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0262 0.3661
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0559 0.0522
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0065 0.0078
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.1314 0.128
Onchocerca volvulus 0.0102 0.104 0.3774
Schistosoma mansoni alpha glucosidase 0.0037 0.0262 0.032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.104 0.1434
Echinococcus multilocularis musashi 0.0027 0.0151 0.0112
Trichomonas vaginalis spcc417.12 protein, putative 0.0102 0.104 0.251
Echinococcus multilocularis transcription factor eb 0.0105 0.1077 0.1041
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0729
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0612 0.0574
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.069 0.0273
Brugia malayi hypothetical protein 0.0018 0.004 0.0047
Echinococcus multilocularis zinc finger protein 0.0041 0.0313 0.0275
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.069 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.3359 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1001 0.1378
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1457 0.1423
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.104 0.1434
Loa Loa (eye worm) hypothetical protein 0.0456 0.5238 0.624
Mycobacterium ulcerans carboxylesterase, LipT 0.0102 0.104 0.6667
Mycobacterium tuberculosis Conserved protein 0.0073 0.069 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0279 0.0333
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0984 0.1355
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0191 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0225 0.25 0.2471
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.3359 1
Echinococcus multilocularis neuroligin 0.0102 0.104 0.1004
Onchocerca volvulus 0.0147 0.1573 0.5787
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0102 0.104 0.1002
Onchocerca volvulus 0.0073 0.069 0.2456
Echinococcus granulosus geminin 0.035 0.398 0.4717
Schistosoma mansoni hypothetical protein 0.004 0.0298 0.037
Schistosoma mansoni hypothetical protein 0.035 0.398 0.5652
Schistosoma mansoni hypothetical protein 0.004 0.0298 0.037
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0262 0.3661
Schistosoma mansoni lamin 0.0027 0.0151 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0065 0.0078
Schistosoma mansoni hypothetical protein 0.0043 0.034 0.0431
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0151 0.018
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.1795 0.2102
Loa Loa (eye worm) hypothetical protein 0.0081 0.0782 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0279 0.0333
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0967 0.0931
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0279 0.0287
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0065 0.0031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0191 0.0152
Onchocerca volvulus 0.0102 0.104 0.3774
Brugia malayi nuclear receptor NHR-67 0.0018 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Mycobacterium ulcerans lipase LipD 0.0073 0.069 0.4393
Brugia malayi Carboxylesterase family protein 0.0102 0.104 0.1239
Loa Loa (eye worm) hypothetical protein 0.0086 0.0841 0.1002
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Schistosoma mansoni hypothetical protein 0.0147 0.1573 0.2199
Mycobacterium ulcerans beta-lactamase 0.0073 0.069 0.4393
Toxoplasma gondii ABC1 family protein 0.0073 0.069 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0078
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0257 0.1575
Echinococcus multilocularis carboxylesterase 5A 0.0605 0.7012 0.7
Echinococcus multilocularis acetylcholinesterase 0.0605 0.7012 0.7
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0279 0.0287
Brugia malayi Pre-SET motif family protein 0.003 0.0186 0.0222
Schistosoma mansoni hypothetical protein 0.004 0.0298 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0612 0.082
Brugia malayi nuclear receptor NHR-88 0.0018 0.004 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0559 0.0622
Loa Loa (eye worm) DR-78 0.0018 0.004 0.0047
Onchocerca volvulus 0.0102 0.104 0.3774
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.069 0.1381
Mycobacterium tuberculosis Conserved protein 0.0073 0.069 0.0273
Loa Loa (eye worm) carboxylesterase 0.0605 0.7012 0.8354
Trichomonas vaginalis esterase, putative 0.0073 0.069 0.1381
Trichomonas vaginalis set domain proteins, putative 0.0241 0.2689 0.7837
Brugia malayi nuclear receptor NHR-88 0.0038 0.0279 0.0333
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0015 0.0018
Onchocerca volvulus 0.0037 0.0263 0.0845
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0279 0.0333
Brugia malayi PAS domain containing protein 0.0049 0.0409 0.0487
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0279 0.0344
Brugia malayi hypothetical protein 0.0129 0.1363 0.1623
Schistosoma mansoni single-minded 0.0049 0.0409 0.053
Trypanosoma cruzi ISWI complex protein 0.0032 0.0207 0.2837
Echinococcus multilocularis lamin dm0 0.0027 0.0151 0.0112
Schistosoma mansoni zinc finger protein 0.0041 0.0313 0.0393
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Onchocerca volvulus 0.0096 0.0965 0.3491
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.069 0.1381
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Brugia malayi beta-lactamase family protein 0.0073 0.069 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0279 0.0333
Onchocerca volvulus 0.0027 0.0151 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0315 0.017
Brugia malayi nuclear hormone receptor 0.0018 0.004 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.104 0.1434
Loa Loa (eye worm) zinc finger protein 0.0315 0.3564 0.4247
Echinococcus granulosus expressed conserved protein 0.009 0.0898 0.1027
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0151 0.018
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0102 0.104 0.1197
Echinococcus granulosus transcription factor eb 0.0105 0.1077 0.1242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.069 0.0933
Loa Loa (eye worm) hypothetical protein 0.0722 0.8393 1
Brugia malayi hypothetical protein 0.0102 0.104 0.1239
Schistosoma mansoni lamin 0.0027 0.0151 0.016
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.1239
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0262 0.0313
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.1795 0.2139
Mycobacterium tuberculosis Carboxylesterase LipT 0.0102 0.104 0.1002
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0078
Echinococcus multilocularis acetylcholinesterase 0.0605 0.7012 0.7
Loa Loa (eye worm) hypothetical protein 0.0605 0.7012 0.8354
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0279 0.0905
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0262 0.3661
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1209 0.1441
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0047
Schistosoma mansoni neuroligin 3 (S09 family) 0.0102 0.104 0.1434
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0262 0.0224
Brugia malayi nuclear receptor RXR 0.0018 0.004 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.1795 0.2139
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0279 0.0333
Brugia malayi beta-lactamase family protein 0.0073 0.069 0.0822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0612 0.082
Mycobacterium tuberculosis Conserved protein 0.0073 0.069 0.0273
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0186 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0981 0.1169
Echinococcus multilocularis geminin 0.035 0.398 0.3956
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.069 0.0822
Brugia malayi Carboxylesterase family protein 0.0605 0.7012 0.8354
Brugia malayi Nuclear hormone receptor E75 0.0018 0.004 0.0047
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0217
Echinococcus multilocularis muscleblind protein 0.0456 0.5238 0.5219
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.0073 0.069 0.0822
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0217
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.004 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0722 0.8393 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0105 0.1071 0.1276
Schistosoma mansoni gliotactin 0.0102 0.104 0.1434
Echinococcus granulosus para nitrobenzyl esterase 0.0102 0.104 0.1197
Schistosoma mansoni hypothetical protein 0.0067 0.0616 0.0826
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0559 0.7406
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.1001 0.1192
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.069 0.0273
Echinococcus multilocularis BC026374 protein (S09 family) 0.0102 0.104 0.1004

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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